Publications by authors named "Kosmas Alexandros Pervanidis"
Article Synopsis
- - Akt kinase plays a crucial role in cell functions such as growth, survival, metabolism, and migration, and its dysregulation is linked to cancer and metabolic disorders.
- - Research into Akt inhibitors aims to counteract overactive Akt signaling, with three main types: ATP-competitive, allosteric, and covalent-allosteric inhibitors, each functioning in different ways to inhibit Akt activity.
- - Capivasertib, an ATP-competitive inhibitor, was recently approved by the FDA for breast cancer treatment, but challenges like selectivity, biomarker identification, and reducing side effects remain, especially for covalent-allosteric inhibitors that show promise for future therapies.
