Towards Automatic Object Detection and Activity Recognition in Indoor Climbing.

Rock climbing has propelled from niche sport to mainstream free-time activity and Olympic sport. Moreover, climbing can be studied as an example of a high-stakes perception-action task. However, understanding what constitutes an expert climber is not simple or straightforward.

Predictors in Youth of Adult Cardiovascular Events.

Background And Objectives: Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular events in adulthood.

Methods: The study comprised 11 550 participants from 7 longitudinal cohort studies in the United States, Australia, and Finland with risk factor measurements in adolescence and followed into adulthood.

Multitype Quantum Well Semiconductor Membrane External-Cavity Surface-Emitting Lasers for Widely Tunable Continuous Wave Operation.

Membrane external-cavity surface-emitting lasers (MECSELs) represent a cutting-edge approach in pushing the performance boundaries of vertically emitting semiconductor lasers. The fundamental concept of employing an extremely thin gain membrane, spanning from hundreds of nanometers to a few micrometers in thickness and sandwiched between transparent heat spreaders, introduces novel opportunities through uniform double-sided optical pumping and enhanced heat dissipation from the active region. Additionally, these advantages of MECSELs facilitate more intricate band gap engineering possibilities for the active region by integrating multiple types of quantum wells (QWs) into a single laser gain structure.

A short simulated nature experience as an effective way to promote restoration from work-related stress.

Spending time in nature, and even watching images or videos of nature, has positive effects on one's mental state. However, cognitively stressful work is often performed indoors, in offices that lack easy access to nature during breaks. In this study, we investigated whether watching a 5-min audiovisual video that describes a first-person perspective walk on a forest path could help to restore one's mental state after cognitive stress.

Survey data on customer two-stage decision-making process in household vacuum cleaner market.

This paper presents the data collection method and introduces the dataset about consumers' consider-then-choose behaviors in the household vacuum cleaner market. First, we designed a questionnaire that collected participants' consideration and choice data, social network data, demographic information, and preferences for product features. In addition, we obtained data on vacuum cleaner product features through web scraping from online shopping websites.

Optimization of Selective Hydrometallurgical Tantalum Recovery from E-Waste Using Zeolites.

To protect future high-tech metal demand, a selective and efficient recovery method for tantalum from a tantalum-rich e-waste component sample was developed. Ultrasound-assisted digestion of the component sample was optimized, and the highest dissolution rate was achieved using a mixture of 8 mol/L HSO and HF at a temperature of 60 °C. The determined amount of tantalum was as high as 11 000 ± 1000 mg/kg, which results in a high potential for recyclable tantalum.

Subclinical atherosclerosis in young adults predicting cardiovascular disease: The Cardiovascular Risk in Young Finns Study.

Background And Aims: Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are at risk of developing atherosclerotic cardiovascular disease (ASCVD).

Methods: A total of 2641 individuals free of ASCVD were examined at the mean age of 32 years (range 24-45 years) for carotid artery intima-media thickness (IMT) and carotid plaques, carotid artery elasticity, and brachial artery flow-mediated endothelium-dependent vasodilation (FMD).

Priority populations' experiences of isolation, quarantine and distancing for COVID-19: protocol for a longitudinal cohort study (Optimise Study).

Introduction: Longitudinal studies can provide timely and accurate information to evaluate and inform COVID-19 control and mitigation strategies and future pandemic preparedness. The Optimise Study is a multidisciplinary research platform established in the Australian state of Victoria in September 2020 to collect epidemiological, social, psychological and behavioural data from priority populations. It aims to understand changing public attitudes, behaviours and experiences of COVID-19 and inform epidemic modelling and support responsive government policy.

Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness.

Importance: Although cardiovascular disease (CVD) begins in early life, the extent to which blood pressure (BP) at different life stages contributes to CVD is unclear.

Objective: To determine the relative contribution of BP at different life stages across the early-life course from infancy to young adulthood with carotid intima-media thickness (IMT).

Design, Setting, And Participants: The analyses were performed in 2022 using data gathered from July 1989 through January 2018 within the Special Turku Coronary Risk Factor Intervention Project, a randomized, infancy-onset cohort of 534 participants coupled with annual BP (from age 7 months to 20 years), biennial IMT measurements (from ages 13 to 19 years), who were followed up with again at age 26 years.

Multilevel longitudinal analysis of social networks.

Stochastic actor-oriented models (SAOMs) are a modelling framework for analysing network dynamics using network panel data. This paper extends the SAOM to the analysis of multilevel network panels through a random coefficient model, estimated with a Bayesian approach. The proposed model allows testing theories about network dynamics, social influence, and interdependence of multiple networks.

Protein Adsorption and Its Effects on Electroanalytical Performance of Nanocellulose/Carbon Nanotube Composite Electrodes.

Protein fouling is a critical issue in the development of electrochemical sensors for medical applications, as it can significantly impact their sensitivity, stability, and reliability. Modifying planar electrodes with conductive nanomaterials that possess a high surface area, such as carbon nanotubes (CNTs), has been shown to significantly improve fouling resistance and sensitivity. However, the inherent hydrophobicity of CNTs and their poor dispersibility in solvents pose challenges in optimizing such electrode architectures for maximum sensitivity.

Introduction of an electrochemical point-of-care assay for quantitative determination of paracetamol in finger-prick capillary whole blood samples.

Aims: Measuring venous plasma paracetamol concentrations is time- and resource-consuming. We aimed to validate a novel electrochemical point-of-care (POC) assay for rapid paracetamol concentration determinations.

Methods: Twelve healthy volunteers received 1 g oral paracetamol, and its concentrations were analysed 10 times over 12 h for capillary whole blood (POC), venous plasma (high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS)), and dried capillary blood (HPLC-MS/MS).

Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial.

Background: Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that protects dopamine neurons and improves motor function in animal models of Parkinson's disease (PD).

Objective: The primary objectives of this study were to assess the safety and tolerability of both CDNF and the drug delivery system (DDS) in patients with PD of moderate severity.

Methods: We assessed the safety and tolerability of monthly intraputamenal CDNF infusions in patients with PD using an investigational DDS, a bone-anchored transcutaneous port connected to four catheters.

Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study.

Background Childhood exposure to dyslipidemia is associated with adult atherosclerosis, but it is unclear whether the long-term risk associated with dyslipidemia is attenuated on its resolution by adulthood. We aimed to address this question by examining the links between childhood and adult dyslipidemia on carotid atherosclerotic plaques in adulthood. Methods and Results The Cardiovascular Risk in Young Finns Study is a prospective follow-up of children that began in 1980.

Impact of Intraprocedural Pressure Changes on Hemodynamic Outcome During Self-Expanding TAVR.

Introduction: During the transcatheter aortic valve replacement (TAVR) procedure, hemodynamic measurements can be used to evaluate transcatheter heart valve (THV) performance. We hypothesized that the occurrence of a significant decrease in invasive aortic pressure immediately after annular contact by a self-expanding THV indicates effective annular sealing. This phenomenon could thus be used as a marker for the occurrence of paravalvular leak (PVL).

Mechanocardiography-Based Measurement System Indicating Changes in Heart Failure Patients during Hospital Admission and Discharge.

Heart failure (HF) is a disease related to impaired performance of the heart and is a significant cause of mortality and treatment costs in the world. During its progression, HF causes worsening (decompensation) periods which generally require hospital care. In order to reduce the suffering of the patients and the treatment cost, avoiding unnecessary hospital visits is essential, as hospitalization can be prevented by medication.

Utilizing Grasp Monitoring to Predict Microsurgical Expertise.

Introduction: Most microsurgical procedures require the surgeon to use tools to grasp and hold fragile objects in the surgical site. Prior research on grasping in surgery has mostly either been in other surgical techniques or used grasping as an auxiliary metric. We focus on microsurgery and investigate what grasping can tell about microsurgical skill and suturing performance.

Multilevel network interventions: Goals, actions, and outcomes.

COVID-19 has resulted in dramatic and widespread social network interventions across the globe, with public health measures such as distancing and isolation key epidemiological responses to minimize transmission. Because these measures affect social interactions between people, the networked structure of daily lives is changed. Such largescale changes to social structures, present simultaneously across many different societies and touching many different people, give renewed significance to the conceptualization of social network interventions.

Prudent Antimicrobial Use Is Essential to Prevent the Emergence of Antimicrobial Resistance in 4/O:3 Strains in Pigs.

is a psychrotrophic zoonotic foodborne pathogen. Pigs are considered the main reservoir of 4/O:3, which is the most commonly isolated bioserotype in many European countries. Consuming pork contaminated with can be a health threat, and antimicrobial-resistant strains may complicate the treatment of the most severe forms of yersiniosis.

Automated tool detection with deep learning for monitoring kinematics and eye-hand coordination in microsurgery.

In microsurgical procedures, surgeons use micro-instruments under high magnifications to handle delicate tissues. These procedures require highly skilled attentional and motor control for planning and implementing eye-hand coordination strategies. Eye-hand coordination in surgery has mostly been studied in open, laparoscopic, and robot-assisted surgeries, as there are no available tools to perform automatic tool detection in microsurgery.

Movement-level process modeling of microsurgical bimanual and unimanual tasks.

Purpose: Microsurgical techniques require highly skilled manual handling of specialized surgical instruments. Surgical process models are central for objective evaluation of these skills, enabling data-driven solutions that can improve intraoperative efficiency.

Method: We built a surgical process model, defined at movement level in terms of elementary surgical actions ([Formula: see text]) and targets ([Formula: see text]).

Clinical validation of automated and rapid mariPOC SARS-CoV-2 antigen test.

COVID-19 diagnostics was quickly ramped up worldwide early 2020 based on the detection of viral RNA. However, based on the scientific knowledge for pre-existing coronaviruses, it was expected that the SARS-CoV-2 RNA will be detected from symptomatic and at significant rates also from asymptomatic individuals due to persistence of non-infectious RNA. To increase the efficacy of diagnostics, surveillance, screening and pandemic control, rapid methods, such as antigen tests, are needed for decentralized testing and to assess infectiousness.

A molecular-based identification resource for the arthropods of Finland.

To associate specimens identified by molecular characters to other biological knowledge, we need reference sequences annotated by Linnaean taxonomy. In this study, we (1) report the creation of a comprehensive reference library of DNA barcodes for the arthropods of an entire country (Finland), (2) publish this library, and (3) deliver a new identification tool for insects and spiders, as based on this resource. The reference library contains mtDNA COI barcodes for 11,275 (43%) of 26,437 arthropod species known from Finland, including 10,811 (45%) of 23,956 insect species.