Publications by authors named "Koski T"

Article Synopsis
  • * A literature review investigates genetic and pathogenic factors contributing to both idiopathic and adult degenerative scoliosis, examining their complex origins and mechanisms through data sourced from PubMed and Google Scholar.
  • * The research categorizes genetic influences on idiopathic scoliosis and identifies factors like inflammation and hormonal changes in adult degenerative scoliosis, while also outlining current research limitations and suggesting future study directions.
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Article Synopsis
  • - The study is a secondary data analysis of an NIH-sponsored research focusing on cost-effectiveness between surgical and non-surgical treatments for Adult Symptomatic Lumbar Scoliosis (ASLS) eight years post-enrollment.
  • - Previous analyses at the five-year mark showed a cost-effectiveness ratio (ICER) of $44,033 (As-Treated) and $27,480 (Intent-to-treat), while the current eight-year data suggests that surgical treatment is more economically favorable, with an ICER of $20,569 per Quality Adjusted Life Year (QALY) gained.
  • - The conclusion highlights that operative treatment for ASLS presents a more cost-effective option compared to non-operative treatment, as indicated
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Objective: Postural abnormalities are a debilitating symptom of Parkinson disease (PD) that may require spinal intervention. Camptocormia is a unique abnormality most seen in PD, defined by a severe forward flexion of the trunk that completely resolves when supine. The condition presents a challenge due to an undefined pathophysiology and optimal therapeutic approach in a high-risk patient population.

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  • Endophytes play a crucial role in plant-insect interactions, yet their specific contributions to managing Emerald Ash Borer (EAB) infestations are not well understood.
  • Utilizing advanced genetic analysis methods, the study compares the endophytic fungi and bacteria in the phloem of EAB-infested and healthy samples, revealing significant shifts in community structure and diversity due to infestation.
  • The results indicate that while fungal diversity declines and shifts significantly, bacterial abundance increases without diversity change, highlighting complex interactions that could inform better pest control strategies.
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  • Emerald ash borer (EAB) is an invasive pest severely affecting ash trees in North America and Europe, with native ash species showing resistance due to unknown mechanisms.
  • A study compared the phloem mycobiomes and metabolites of native and nonnative ash species, finding significant differences in mycobiome communities but no impact from EAB infestation.
  • The research highlights a complex relationship between tree chemistry and mycobiomes, suggesting that the co-evolution of native trees and EAB plays a role in their interactions.
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Article Synopsis
  • - The study focused on metastatic spinal tumors from primary thyroid carcinoma, analyzing patient demographics, tumor characteristics, and treatment outcomes from surgical cases.
  • - Twelve patients were treated, revealing a mix of thyroid tumor types, with an average of 2.5 spinal metastases per patient; most received additional radiation post-surgery, but survival rates didn't significantly differ based on treatment type.
  • - While surgery showed effectiveness for managing these tumors, 41.7% of patients faced complications, highlighting the need for further research on survival predictors and treatment outcomes.
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Objective This study examined the interaction between adolescent idiopathic scoliosis (AIS) and pregnancy, focusing on pregnancy outcomes, changes in back pain, and anesthesia use. Methods A retrospective analysis was conducted on adult patients with AIS who gave birth at our institution between 2006 and 2022. Results A total of 163 AIS patients with 263 pregnancies were included.

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Study Design: A retrospective cohort study.

Objective: To calculate the magnitude of any increased risk of epidural hematoma (EDH) associated with chemoprophylactic anticoagulation (chemoprophylaxis), if any.

Summary Of Background Data: Chemoprophylaxis for the prevention of venous thromboembolic events may be associated with an increased risk of EDH after spine surgery.

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Objective: Venous thromboembolic event (VTE) after spine surgery is a rare but potentially devastating complication. With the advent of machine learning, an opportunity exists for more accurate prediction of such events to aid in prevention and treatment.

Methods: Seven models were screened using 108 database variables and 62 preoperative variables.

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Since the discovery of the ash tree ( spp.) killer emerald ash borer (EAB; ) in the United States in 2002 and Moscow, Russia in 2003, substantial detection and management efforts have been applied to contain and monitor its spread and mitigate impacts. Despite these efforts, the pest continues to spread within North America.

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The general objectives of spine surgery are to alleviate pain, restore neurologic function, and prevent or treat spinal deformities or instability. The accumulating expanse of outcome measures has allowed us to more objectively quantify these variables and, therefore, gauge the success of treatments, ultimately improving the quality of the delivered health care. It has become increasingly evident that spinal conditions and their accompanying interventions affect all aspects of a patient's life, including their physical, mental, emotional, and social well-being.

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The craniovertebral junction (CVJ) involves the atlas, axis, and occiput along with the atlanto-occipital and atlantoaxial joints. The anatomy and neural and vascular anatomy of the junction render the CVJ unique. Specialists treating disorders that affect the CVJ must appreciate its intricate anatomy and should be well versed in its biomechanics.

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The global aging population has led to an increase in geriatric diseases, including adult degenerative scoliosis (ADS). ADS is a spinal deformity affecting adults, particularly females. It is characterized by asymmetric intervertebral disc and facet joint degeneration, leading to spinal imbalance that can result in severe pain and neurological deficits, thus significantly reducing the quality of life.

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Article Synopsis
  • Insect gut microbiota play a crucial role in helping wood-boring insects, like Cossidae larvae, defeat the defense mechanisms of host trees, particularly ash trees.
  • Researchers isolated gut bacteria from these larvae, tested their ability to break down pinoresinol (a tree defense compound) and cellulose, and identified the byproducts of this degradation.
  • All isolated gut bacteria could degrade pinoresinol, with some also able to break down cellulose, suggesting that these microbes not only aid in overcoming tree defenses but may also support the nutritional needs of the insects through carbohydrate synthesis.
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Bark beetles are an economically and ecologically important insect group, with aggregation behavior and thus host colonization success depends on pheromone-mediated communication. For some species, such as the major invasive forest pest in China, red turpentine beetle (Dendroctonus valens), gut microbiota participates in pheromone production by converting tree monoterpenes into pheromone products. However, how variation in gut microenvironment, such as pH, affects the gut microbial composition, and consequently pheromone production, is unknown.

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Study Design: This is a cross-sectional survey.

Objective: The aim was to assess the reliability of a proposed novel classification system for thoracic disc herniations (TDHs).

Summary Of Background Data: TDHs are complex entities varying substantially in many factors, including size, location, and calcification.

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Objective: The coronavirus disease 2019 (COVID-19) pandemic has necessitated the use of telehealth visits (THVs). The effects on neurosurgical practice have not been well characterized, especially concerning new-patient THVs. Therefore, the authors of this study reviewed their institution's experience with outpatient clinic visits and THVs from before the COVID-19 pandemic to the present to focus on clinical metrics, rates of surgery, and the effects of implementing THVs in order to better understand their implications for clinical practice as more data emerge over time.

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Many pathogens rely on their insect vectors for transmission. Such pathogens are under selection to improve vector competence for their transmission by employing various tissue or cellular responses of vectors. However, whether pathogens can actively cause hypoxia in vectors and exploit hypoxia responses to promote their vector competence is still unknown.

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The craniovertebral junction (CVJ), or the "first junction," can be affected by a variety of pathological states. Some of these conditions could represent a gray area in that they can be treated by general neurosurgeons or such specialists as skull base or spinal surgeons. However, some conditions are best managed with a multidisciplinary approach.

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In this third article in a 3-article series on the craniocervical junction, we define the terms "basilar impression," "cranial settling," "basilar invagination," and "platybasia," noting that these terms are often used interchangeably but represent distinct entities. We then provide examples that represent these pathologies and treatment paradigms. Finally, we discuss the challenges and future direction in the craniovertebral junction surgery space.

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Objective: Anterior lumbar fusions are thought to be associated with elevated venous thromboembolic event (VTE) rates, but the magnitude of this increase in VTE is not well described. The objective of this study was to quantify any increase in VTE caused by anterior approach lumbar fusion.

Methods: 1147 consecutive lumbar fusions performed at our institution over a six-year period were identified, and clinical and demographic data were collected.

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Study Design: Retrospective cohort.

Objective: To quantify any reduction in venous thromboembolic events (VTEs) caused by chemoprophylaxis among lumbar surgery patients.

Summary Of Background Data: Chemoprophylactic anticoagulation (chemoprophylaxis) is used to prevent VTE after lumbar surgery.

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Background: Most posterior spinal fusion (PSF) patients do not require admission to an intensive care unit (ICU), and those who do may represent an underinvestigated, high-risk subpopulation.

Objective: To identify the microbial profile of and risk factors for surgical site infection (SSI) in PSF patients admitted to the ICU postoperatively.

Methods: We examined 3965 consecutive PSF patients treated at our institution between 2000 and 2015 and collected demographic, clinical, and procedural data.

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Semiochemical-based management strategies are important for controlling bark beetles, such as invasive Red Turpentine Beetle (Denroctonus valens), the causal agent for mass mortality of pine trees (Pinus spp.) in China. It has been previously shown that the pheromone verbenone regulates the attack density of this beetle in a dose-dependent manner and that the gut bacteria of D.

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