Publications by authors named "Koshun Inada"
Article Synopsis
- - Nalmefene, an opioid receptor antagonist and partial agonist, shows potential in reducing alcohol consumption among patients with alcohol dependence but its effects on atherosclerosis and cardiovascular risks are still unclear.
- - In a study using ApoE knockout mice, nalmefene administration resulted in dose-dependent increases in atherosclerotic plaque formation and macrophage-rich plaques, raising concerns about its potential cardiovascular risks.
- - The research indicated that nalmefene enhances the expression of the scavenger receptor CD36 in macrophages, leading to increased uptake of oxidized LDL, suggesting a potential mechanism for the increased atherosclerosis observed in the study.
Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice.
Biochem Biophys Res Commun
November 2022
Article Synopsis
- Fluoroquinolones, commonly prescribed antibiotics, are linked to an increased risk of aortic aneurysm and dissection (AAD), but the exact mechanism of this side effect is not well understood.
- A study was conducted on male mice to assess the impact of moxifloxacin, a type of fluoroquinolone, on AAD, showing that it induced the condition and caused damage to aortic tissues.
- The findings revealed that moxifloxacin increased levels of osteopontin and matrix metalloproteinases-2 while decreasing smooth muscle protein 22α, suggesting it promotes AAD development by weakening aortic wall structure.
Varenicline is a widely used and effective drug for smoking cessation. We have previously reported experimental evidence suggesting that varenicline increases the risk of cardiovascular events. Varenicline progresses atherosclerotic plaque formation in apolipoprotein E knockout (ApoE KO) mice.
View Article and Find Full Text PDFVarenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. However, it remains unknown whether varenicline affects cardiovascular events in patients with nicotine addiction.
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