[Effects of sodium nucleinate on immunological and nonspecific responsiveness in elderly and senile patients].

Sixty-two elderly and senile patients with pulmonary tuberculosis were examined. Of them 32 had multimodality therapy involving sodium nucleinate. The inclusion of sodium nucleinate into a complex of therapeutical measures for the patients promotes improvement of T-cellular immunity.

[Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using T-activin].

Fifty six patients with pulmonary tuberculosis were examined. Of them 30 had T-activin in multimodality treatment. To supplement the agent in elderly and old patients was found to elevate the counts of T lymphocytes and T helper cells, to normalize Tx/Tc ratios, to enhance T lymphocytic activity and IL-2 synthesis.

[Immune status of middle-aged and aged patients with tuberculosis].

After examination of 165 tuberculous patient of presenile and senile age, 150 young patients, 65 healthy presenile and senile donors, 56 young healthy donors it was established that young and aged healthy donors differ by some parameters of T-cell immunity (inhibited blast-transformation response to PHA, reduced number of T-helpers, high suppressive activity of induced Con-A. Young tuberculous patients differ from their healthy counterparts by a variety of immunological parameters (low T-lymphocyte and helper count, poor blast-transformation, increased number of T-suppressors and induced ConA suppression, B-lymphocyte count and serum IgG level). Immunological reactivity is the least in aged tuberculous patients.