Multicenter, randomized, open-label, comparative study of the effectiveness of nasal spray Aqua Maris Extra Strong as a symptomatic therapy in the technology of delayed antibiotic prescription in the treatment of acute rhinosinusitis in children aged 6-11 years.

Unlabelled: Antibacterial therapy in acute rhinosinusitis (ARS) is prescribed 4-9 times more often than recommended, while no >5 % of patients require such treatment. The main motive for the irrational antibiotic prescription is the presence of mucopurulent discharge and nasal congestion in combination with hyperthermia. The study objective was to determine the efficacy of hypertonic seawater solution in the technology of delayed antibiotic prescription in patients with ARS.

FEATURES OF THE CONNECTIVE TISSUE COMPONENT OF THE PALATINE TONSILS IN PATIENTS WITH RECURRENT TONSILLITIS.

Objective: The aim: To explore the morphological changes of palatine tonsil at the levels of the epithelial layer and connective tissue; to determine the relative area of the connective tissue component in the tonsillar tissue (fibrosis) in patients with recurrent tonsillitis compared to the control.

Patients And Methods: Materials and methods: This study presents a morphological assessment of the palatine tonsils of 10 people. Tonsils' material with surrounding tissue was fixed in 10% formalin solution.

Clinical efficiency of allergen-specific immunotherapy with fungal allergens in patients with chronic polypous rhinosinusitis against the background of fungal sensitization.

Fungal flora is one of the causes of inflammatory, including polypous, processes in the nasal cavity. In this regard, studies aimed at reducing the effect of fungal sensitization (FS) on the course of chronic polypous rhinosinusitis (CPRS) are relevant. The objective of the study was to evaluate the effect of various treatment options on the clinical course of the disease in patients with chronic polypous rhinosinusitis against the background of sensitization to fungi.

CLINICAL AND LABORATORY JUSTIFICATION FOR USE OF POLYVALENT BACTERIOPHAGE IN TECHNIQUE OF DELAYED PRESCRIBING OF ANTIBIOTICS IN PATIENTS WITH ARS.

Objective: The aim: Of research was to evaluate the effectiveness of bacteriophage in patients with acute rhinosinusitis in respect of technique of delayed prescribing of antibiotics.

Patients And Methods: Materials and methods: There were examined 155 patients who were given irrigation therapy with isotonic solution of sea water 4 times a day and mometasone furoate of 100 mg twice a day for 10 days. The patients of intervention group (n - 80) were additionally prescribed the polyvalent bacteriophage endonasally, in drops of 2-10 ml 3 times a day.

An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis.

Unlabelled: Acute rhinosinusitis (ARS) can be characterized as bacterial (ABRS) and require antibiotic therapy only in 0.5-5% of cases. In most cases, the disease is in a viral and post-viral form, which requires pathogenetic and symptomatic treatment.

A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years.

Unlabelled: Seventy to 95% of acute tonsillitis episodes are caused by viral infection, therefore why antibiotic therapy is not indicated in majority of cases. In such cases, acetaminophen or ibuprofen are used to alleviate the symptoms. The objective of this study was assessment of efficacy of phytoneering extract BNO 1030 (Imupret®) in patients with acute non-bacterial tonsillitis.

[Embolization of mammary artery branches after mammary artery bypass surgery].

Even after performed mammary artery bypass surgery, some patients continued to have clinical manifestations of angina pectoris. This may be associated with the development of coronary stealing syndrome due to the fact that the native intrathoracic artery has large lateral branches. Current methods for embolization of arteries of different diameters make it possible to accomplish this task reasonably safely and in full measure.

[Hematopoietic cells of fetal liver. 1. Effect of growth factors of varying origin and activity of granulocyte-macrophage progenitor cells].

The liver is the leading hemopoietic organ of 5-22-week embryo and fetus. Hepatic hemopoiesis activity is assessed by concentration, total count and proliferative capacity of granulomonocytic cell precursors (GMCP). Cloning efficacy (GMCP CE) in the liver of 7 fetuses of 16-22 weeks of gestation was evaluated in vitro.

[The use of fibrin glue in abdominal surgery].

The data on use of fibrin glue (FG) in 215 patients operated on the abdominal organs, employing laser surgical techniques, are presented. In 132 patients, the complicated forms of gastric and duodenal ulcer disease, in 25--gastric cancer, in 24--colonic tumors, in 26--injuries to the liver were revealed. Considerable reduction in incidence of early postoperative complications as compared with that in patients operated on with the use of conventional techniques was noted.

[Expression of glucocorticoid receptors and blast cell clearance in children with different variants of acute lymphoblastic leukemia].

Glucocorticoid receptor (GR) levels were estimated in blast cells of 24 children with acute lymphoblastic leukemia, in different immunocytologic subvariants of the disease. No relationship was revealed between immunophenotype and GR number in blasts. It was found that the response to prednisolone therapy did not depend on the number of sites specifically bound to glucocorticoids.

[State of lipid peroxidation processes and cyclase system components in lymphocytes and blood plasma of children with aplastic anemia].

Lipid peroxidation, antioxidant defence enzymes in lymphocytes and the content of cyclonucleotides in blood plasma were examined in children (3 groups) with aplastic anemia. The groups were formed depending on the disease stages in the examined. Disorders in the distribution of the activity of antioxidant defence enzymes, in the content of hydroperoxides and malonic aldehyde were discovered, with these disorders being diverse and dependent on the disease stage.

[Health status of children exposed to low doses of radiation 1 year after the Chernobyl AES accident].

The authors provide data on the health status of children living in radiation polluted regions, obtained 9-11 months after the Chernobyl accident. Study of the demographic characteristics, distribution into health groups and of the hematological parameters did not reveal any significant differences with the exception of a higher anemia incidence (in children under 1 year).

[Stromal fibroblasts of normal bone marrow in children].

Reference values of the number and proliferation index (PI) of stromal fibroblasts in children have been presented: CFUf per 10(5) = 57.0 +/- 4.1; CFUf in 1 microliters = 85.

[Late (after 5-year remission) recurrences of acute leukemia in children (a cooperative study)].

Cooperative investigations were conducted in seven Pediatric Hematologic Clinics (in Moscow, Leningrad, Kiev, Minsk and Tbilisi) to study the nature of late (after five years of remission) relapses of acute leukemia that were diagnosed in 21.6% of cases (in 80 out of 371 children) with long-term remissions. Late relapses in most patients occurred on the 6-7th year of remission.

[Circulating granulomonocytic precursor cells and phenotype of peripheral blood monocytes in premature infants].

The functional state of granulomonocytic hemopoietic stem cells was investigated in 72 premature infants in the neonatal period. New data were obtained on the concentration of committed granulomonocytic precursors, and on the characteristics of the phenotype of monocytes--the final differentiation component of this series. These data have verified the present notions on the features of nonspecific adaptation reactions in premature newborns.

[Effects of glucocorticoid therapy on membrane markers of lymphocytes and monocytes in children with chronic idiopathic thrombocytopenic purpura].

The treatment with glucocorticoids brings about a decrease in the expression of Ia-like and LFA-J antigens on the membrane surface of peripheral blood lymphocytes and monocytes, diminution of the relative count of monocytes with fixed immunoglobulins (with Fc-receptors). A reduction of the count of B lymphocytes and monocytes with Ia and LFA-J antigens in the spleen was recorded. The hematologic effect attained in the treatment with glucocorticoids was determined by the combined effect of the drugs: by the blockade of monocyte/macrophage receptors and by the redistributiion++ action of prednisolone leading to the release of blood platelets from the bone marrow to the blood bed.