A multicenter multinational study to evaluate different aspects of the relationship between MS and pregnancy.

Background: To investigate the pregnancy-related issues in females with multiple sclerosis (MS) from Turkiye, Egypt, Kuwait, and Iran.

Methods: 1692 pregnancies of 701 females with MS were evaluated in this retrospective multicenter, international project. Demographics, clinical features, pregnancy outcomes, relapses, effects of exposure to disease-modifying drugs on pregnancy and fetus, and worries about pregnancy decisions were investigated.

Glucosamine-Mediated Hexosamine Biosynthesis Pathway Activation Uses ATF4 to Promote "Exercise-Like" Angiogenesis and Perfusion Recovery in PAD.

Background: Endothelial cells (ECs) use glycolysis to produce energy. In preclinical models of peripheral arterial disease, further activation of EC glycolysis was ineffective or deleterious in promoting hypoxia-dependent angiogenesis, whereas pentose phosphate pathway activation was effective. Hexosamine biosynthesis pathway, pentose phosphate pathway, and glycolysis are closely linked.

Vitamin D and vitamin D binding protein levels in COVID-19 intensive care unit patients: A prospective multicenter study.

Background: Vitamin D binding protein plays a crucial role in regulating vitamin D levels by carrying vitamin D and its metabolites and immunological response by binding to endotoxins and fatty acids. We aimed to compare vitamin D, DBP, and specific inflammatory markers among intensive care unit (ICU) patients with and without the COVID19 virus.

Methods: This multicenter study in two training and research hospitals included 37 (13 female) COVID-19positive and 51 (34 female) COVID-19-negative ICU patients.

Effect of various surface treatment methods on shear bond strength between acrylic denture teeth and thermoplastic nylon denture base.

Purpose: To evaluate the effect of mechanical, chemical, and mechanical-chemical surface treatment methods on shear bond strength between acrylic denture teeth and thermoplastic nylon denture base.

Materials And Methods: Maxillary central incisor teeth were treated with five different surface treatment methods: mechanical (sandblasting, T-shape diatoric holes), chemical (5% acetic acid solution, bonding agent), and mechanical-chemical (sandblasting + bonding agent) were embedded in thermoplastic nylon denture base (n = 10). A universal testing machine with a crosshead speed of 0.

The level of evidence in prosthodontics in relation to author's characteristics: An analysis of three leading prosthodontics journals.

Purpose: The purpose of this study was to examine the level of evidence (LOE) characteristics and associated factors that change over time in three leading prosthodontics journals.

Materials And Methods: Articles published in The Journal of Prosthetic Dentistry (JPD), International Journal of Prosthodontics (IJP), and Journal of Prosthodontics (JP) in 2013 and 2020 were reviewed by eight independent reviewers. After applying exclusion and inclusion criteria, the number of authors, the corresponding author's educational degree, corresponding author's origin in each clinical research article were recorded.

Automated facial landmark measurement using machine learning: A feasibility study.

Statement Of Problem: Information regarding facial landmark measurement using machine learning (ML) techniques in prosthodontics is lacking.

Purpose: The objective of this study was to evaluate and compare the reliability, validity, and accuracy of facial anthropological measurements using both manual and ML landmark detection techniques.

Material And Methods: Two-dimensional (2D) frontal full-face photographs of 50 men and 50 women were made.

Assessing methodological quality in dental education research using MERSQI: Analysis of publications from two journals.

Purpose: The Medical Education Research Study Quality Instrument (MERSQI) has been used frequently to assess the methodological quality of medical education but not for dental education. The present study aimed to assess the methodological quality using MERSQI scores of articles published in the Journal of Dental Education (JDE) and the European Journal of Dental Education (EJDE).

Methods: A cross-sectional assessment of the quality of manuscripts published in 2012, 2017, and 2022 JDE and EJDE was conducted.

Biological variation of plasma 25-Hydroxyvitamin D, Serum vitamin B12, folate and ferritin in Turkish healthy subject.

Biological variation (BV) plays a crucial role in determining analytical performance specifications, assessing serial measurements of individuals, and establishing the use of population-based reference intervals. Our study aimed to calculate the BV and BV-based quality goals of 25-hydroxyvitamin D (25-OH D), ferritin, folate and vitamin B12 tests. We included a total of 22 apparently healthy volunteers (9 women and 13 men) aged 18-55 years in the study that we conducted in Turkey.

Machine learning model to predict the width of maxillary central incisor from anthropological measurements.

Purpose: To improve smile esthetics, clinicians should comprehensively analyze the face and ensure that the sizes selected for the maxillary anterior teeth are compatible with the available anthropological measurements. The inter commissural (ICW), interalar (IAW), intermedial-canthus (MCW), interlateral-canthus (LCW), and interpupillary (IPW) widths are used to determine the width of maxillary central incisors (CW). The aim of this study was to develop an automated approach using machine learning (ML) algorithms to predict central incisor width in a young Turkish population using anthropological measurements.

Influence of ceramic thickness, background and cement shade on the translucency of zirconia reinforced lithium silicate and lithium disilicate ceramics.

Background: Although, the influence of cement and background shade on the final color and translucency of zirconia reinforced lithium silicate (ZLS) and lithium disilicate (LDS) ceramics has been previously investigated, there is still little data on the translucency of LDS and ZLS ceramics in decreased thickness (0.4 and 0.6 mm).

The Effect of Smoking on Inactivated and mRNA Vaccine Responses Applied to Prevent COVİD-19 in Multiple Sclerosis.

Introduction: Coronavirus disease 2019 (COVID-19) is the biggest health challenge of recent times. Studies so far reveal that vaccination is the only way to prevent this pandemic. There may be factors that decrease or increase vaccine effectiveness.

Predictors and outcomes of conversion to sternotomy in minimally invasive coronary artery bypass grafting.

Background: This study aims to investigate the risk factors and surgical outcomes of conversion to median sternotomy in minimally invasive direct coronary artery bypass grafting.

Methods: Between January 2017 and July 2022, a total of 274 patients (246 males, 28 females; mean age: 57.0±9.

Use of follow-on fingolimod for multiple sclerosis: Analysis of effectiveness and patient reported outcomes in a real-world clinical setting.

Background: Follow-on disease modifying therapies (FO-DMTs) do not always require Phase III studies. There are concerns that cheaper FO-DMTs are only used to reduce healthcare costs. However, the well-being of people with MS (pwMS) should be a priority.

Psychosocial difficulties experienced by MS patients in their quality of life: A comparative study of two countries.

Background: MS is deeply impacted by social factors, such as access to health services, support from official and unofficial sources, and social welfare, which are also thought to contribute to the quality of life of MS patients. The purpose of this study is to examine the quality of life and to analyse the psychosocial challenges of MS patients in North Cyprus and Germany.

Methods: This study was designed with a cross-sectional and comparative research method.

Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE).

Background: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs.

Methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch.

Biological Variations of Seven Clinical Chemistry Analytes and Trolox Equivalent Antioxidant Capacity within Salivary Constituents.

Background: Data on biological variation in saliva samples are quite limited. This study aimed to obtain well-defined biological variation data for seven common clinical chemistry analytes and Trolox equivalent antioxidant capacity (TEAC) in saliva.

Methods: Unstimulated whole saliva and blood samples were collected from thirty-two healthy volunteers of both genders without any history of disease or metabolic syndrome under standard conditions at six different times within three weeks.

The comparative effectiveness of fingolimod, natalizumab, and ocrelizumab in relapsing-remitting multiple sclerosis.

Background: Fingolimod, natalizumab, and ocrelizumab are commonly used in the second-line treatment of relapsing-remitting multiple sclerosis (RRMS). However, these have only been compared in observational studies, not in controlled trials, with limited and inconclusive results being reported. A comparison of their effect on relapse and disability in a real-world setting is therefore needed.

Level of evidence and characteristics of clinical studies published in leading prosthodontics journals.

Statement Of Problem: Data on the level of evidence and the characteristics of studies published in peer-reviewed prosthodontic journals are lacking.

Purpose: The purpose of this study was to investigate the characteristics and level of evidence (LOE) scores of studies published in 3 leading peer-reviewed prosthodontic journals.

Material And Methods: Clinical studies published in the Journal of Prosthetic Dentistry (JPD), the Journal of Prosthodontics (JP), and the International Journal of Prosthodontics (IJP) in 2013 and 2020 were included in the analysis.

Tensile bond strength of soft and hard relining materials to conventional and additively manufactured denture-base materials.

Purpose: Studies comparing tensile bond strength of various soft and hard denture liner materials to conventionally and additively manufactured denture base resins are lacking. The purpose of this study was to investigate the tensile bond strength between chair- and laboratory-side soft and hard relining materials and denture-base materials produced by additive manufacturing and conventional methods.

Materials And Methods: A total of 120 dimethacrylate-based additively manufactured and polymethylmethacrylate (PMMA)-based conventionally fabricated dumbbell-shaped denture-base resins were produced.

Detection of preanalytical errors in arterial blood gas analysis.

Introduction: Blood gas analysis (BGA) is an essential test used for years to provide vital information in critically ill patients. However, the instability of the blood gases is a problem. We aimed to evaluate time and temperature effects on blood gas stability.

The effect of cognitive performance on self-management behavior of multiple sclerosis patients.

Background: Difficulties of self-management in people with MS (pwMS) is considered as one of the most important factors contributing to low rehabilitation efficacy, more severe long-term complications and increase in healthcare costs. Despite the emergence of research in the last decade documenting causes, types, and course of cognitive difficulties in MS disease subtypes, limited evidence is available in the literature for direct comparison of self-management and cognitive deficits. In this study we aimed to investigate the relationship between cognitive performance and self-management in pwMS.