Publications by authors named "Kosei Ishida"
Background: Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the beta-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia.
Results: The normal oral epithelium showed beta-catenin expression only in the cell membrane, but not in the nuclei.
Article Synopsis
- Alpha-enolase and c-myc promoter binding protein 1 are produced by the same gene (ENO1) through different starting points for translation.
- The study used immunohistochemical and in situ hybridization methods to analyze the presence of ENO1 transcripts in normal oral epithelium and oral squamous cell carcinoma, revealing differing distributions.
- ENO1 showed distinct localization patterns in normal cells (in cytoplasm, nuclei, or both) but lacked nuclear presence in carcinoma cells, suggesting that ENO1's localization may be linked to cancer development in the oral epithelium.