Publications by authors named "Kosei Abe"
Article Synopsis
- CART is used to treat ascites that don't respond to diuretics, but issues like increased pressure and filter clogging can occur during the process.* -
- An observation study revealed that clogging is caused by deposits of blood cells and fibrin, linked to the characteristics of the ascitic fluid and levels of certain proteins.* -
- The findings indicate that factors related to cancer, including inflammation and blood clotting processes in the ascitic fluid, contribute to the membrane clogging during CART.*
Article Synopsis
- - The study compared two methods of cell-free and concentrated ascites reinfusion therapy (CART): the internal filtration pressure method and the external filtration pressure method, focusing on circuit pressure and component recovery rates.
- - The internal method showed significantly higher recovery rates for immunoglobulins (IgG, IgA, IgM) and haptoglobin compared to the external method, while the recovery of α-antitrypsin was lower in the internal method.
- - Higher levels of certain proteins like IL-6, haptoglobin, and α-antitrypsin were observed in patients where circuit pressure rose, suggesting these proteins could be linked to the increase in circuit pressure during the therapy.
Objective: Maternal cell contamination (MCC) is known to increase the risk of misdiagnosis in prenatal diagnosis as well as in diagnostic tests for the products of conception (POC) from miscarriages. We aimed to develop a data correction method to salvage fetal karyotype information from single-nucleotide polymorphism (SNP) array data for POC with MCC when parental genotype data are available.
Methods: We obtained SNP array data from mixed genomic DNAs of a mother-child pair and used the dataset to assess the accuracy of data correction.
Epigenetic modifications are thought to serve as a memory of exposure to in utero environments. However, few human studies have investigated the associations between maternal nutritional conditions during pregnancy and epigenetic alterations in offspring. In this study, we report genome-wide methylation profiles for 33 postpartum placentas from pregnancies of normal and foetal growth restriction with various extents of maternal gestational weight gain.
View Article and Find Full Text PDFObjective: The pathophysiology of aldosterone-producing adenomas (APA) has been investigated intensively through genetic and genomic approaches. However, the role of epigenetics in APA is not fully understood. In the present study, we explored the relationship between gene expression and DNA methylation status in APA.
View Article and Find Full Text PDFWith increasing public concern about infertility and the frequent involvement of chromosomal anomalies in miscarriage, analyses of copy number variations (CNVs) have been used to identify the genomic regions responsible for each process of childbearing. Although associations between CNVs and diseases have been reported, many CNVs have also been identified in healthy individuals. Like other types of mutations, phenotypically indefinite CNVs may have been retained and accumulated during anthropogenesis.
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