Publications by authors named "Koscica N"

Background: Teaching clinical pharmacology is often a challenge for medical schools. The benefits and popularity of active recall and spaced repetition through Anki flashcards are well-established and can offer a solution for teaching complex topics, but educators are often unfamiliar with this resource.

Approach: We implemented 501 faculty-generated pharmacology flashcards in five modules across the medical preclinical curriculum, available to 104 first-year students.

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Objective: Stroke is one of the leading causes of disability and death in the world. The endocannabinoid (eCB) system is upregulated in several neurological diseases including stroke. A previous animal study demonstrated an increased expression of the endocannabinoid receptor 1 (CB1R) in the penumbra area surrounding the ischemic core, suggesting a crucial role in inflammation/reperfusion after stroke.

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Background: The correlation between Parkinson disease and malnutrition is well established, however a protein-restricted diet is usually prescribed because of potentially negative interactions between dietary amino acids and l-dopa pharmacokinetics. This strategy could increase the risk of further nutritional deficits.

Methods: A monocentric, prospective, randomized, double-blind pilot study was performed on two groups of Parkinson-affected, protein-restricted, patients: Intervention (n = 7; amino acid supplementation twice daily) and Placebo (n = 7; placebo supplementation twice daily).

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Article Synopsis
  • Acute hemorrhagic leukoencephalitis (AHL) is a rare but serious condition primarily seen in children, marked by sudden onset, rapid progression, and high mortality rates.
  • A 62-year-old man experienced symptoms like double vision and coordination issues after pneumonia, leading to MRI findings that indicated potential AHL, supported by autoimmune responses to Mycoplasma Pneumoniae.
  • Despite intensive treatment including antiviral and steroid therapy, and plasmapheresis, the patient remained in a coma for 30 days before recovering some consciousness and motor function, but still experiences left-sided paralysis.
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