TRANSFORMATION OF UKRAINIAN HEALTHCARE TO THE NEW CONDITIONS OF DEVELOPMENT: RISKS, SOLUTIONS, MODERNISATION OPTIONS.

This article analyses the transformation of Ukrainian healthcare in the context of the new digital healthcare. The study highlights the risks faced by Ukraine's healthcare system and proposes solutions and modernization options to improve the situation.The article conducts a narrative synthesis of related literature with a cross-sectional analysis to analyse the development of Ukrainian telemedicine and its current state in European countries.

EXPERIMENTAL GESTATIONAL DIABETES DISRUPTS THE FORMATION OF IMMUNE TOLERANCE IN OFFSPRING.

Objective: The aim: To analyze the mRNA gene expression level of Aire, Deaf1, Foxp3, Ctla4, Il10, Nlrp3 and distribution of NLRP3+-cells in mesenteric lymph nodes (MLNs) of the offspring of rats with GD, both untreated and treated with glibenclamide and in conditions of insulin oral tolerance formation.

Patients And Methods: Materials and methods: The study involves 160 male rats, one- or six-month-old. The mRNA genes expression was studied by real time quantitative poly¬merase chain reaction.

HOLISTIC APPROACH IN COMMUNICATION SKILLS TEACHING OF MEDICAL STUDENTS.

Objective: The aim: To analyze the relevance of communicative competence in medical practice and to choose the best pedagogical methods by improve communication skills in future doctors through the use of a holistic approach in teaching.

Patients And Methods: Materials and methods: Sociological, informational and analytical research methods were used in the research.

Conclusion: Conclusions: The holistic direction in education promotes partnership between a student and a teacher, the achievement of mutual understanding and trust, better commitment and motivation to learn.

METABOLIC THERAPY IN THE COMPLEX TREATMENT OF CHRONIC PANCREATITIS WITH STABLE CORONARY ARTERY DISEASE.

Objective: The aim: To study the effectiveness of using medicine meldonium in standard therapy to the correction of prooxidant-antioxidant and kallikrein-kinin disorders in patients with chronic pancreatitis andstable coronary artery disease.

Patients And Methods: Materials and methods: The study included 90 patients with chronic pancreatitis andstable coronary artery disease.They were divided into two groups: I group (45 patients) received standard treatment; II group (45 patients) along with basic therapy received medication meldonium (Vazonat) for 2 capsules (500 mg) once daily for two months.

[INDICATORS OF GOUT INTERLAYKINS AND THERMOGRAPHY OF JOINTS ON THE BACKGROUND OF ENTEROSORBTION THERAPY].

Gout is a serious medical, social and economic problem of today. The major factor in its pathogenesis is impaired purine metabolism, which leads to an increase in uric acid concentration and the development of monourate-induced inflammation. Disruption of thermoregulation and regional blood flow is an important clinical and pathogenic manifestation of gout, which can be evaluated by the registration of infrared radiation.

combination effect of hypertonic disease with chronic pancreatitis on the processes maintain homeostasis.

Objective: Introduction: Abnormalities comorbidity - a frequent phenomenon in medical practice. This determines the relevance of research processes maintaining homeostasis with a combination of various diseases. The aim of this study was to examine and compare the character of vegetative, antioxidant, kallikrein-kinin system and parameters of endogenous intoxication disorders in the patients with isolated essential hypertension and with combination of hypertonic disease and chronic pancreatitis.

[The effect of fosamax on bone tissue function in patients with rheumatoid arthritis (based on x-ray densitometry data)].

Data are submitted on results of investigations designed to study mineral density of the osseous tissue in patients with rheumatoid arthritis during therapy with phosamax. Revealed in the study were both a positive clinical effect of the above-named drug and its protective action with respect to systemic resorption of the osseous tissue in patients with rheumatoid arthritis.

[The mineral density of the bone tissue in patients with rheumatic diseases of the joints (based on x-ray densitometry data)].

Manifestations were studied of systemic osteoporosis in patients with rheumatoid arthritis, primary osteoarthrosis, and ankylosing spondylarthritis. There have been disclosed differently directed changes in mineral density of lumbar spine and thigh bone segments related to phase of the illness as well as to the treatments administered, patient age, and impact of the post-menopausal period (in female patients). A conclusion has been reached that it is necessary that the above-mentioned studies be made in order that we might choose relevant therapeutic alternatives for patients with rheumatic afflictions of the joints.