Structure and luminescence properties of EuF and SrF:Eu nanoparticles after microwave plasma annealing in "methane-hydrogen".

Recently, progress has been made in fabricating diamond-based scintillators with integrated rare-earth luminescent particles. These luminescent particles are integrated into the bulk of diamond during their synthesis by chemical vapor deposition (CVD). However, the growth conditions include a chemically aggressive plasma environment and elevated temperatures, which results in the partial degradation of particles and a decrease in the intensity of their luminescence.

Fine-Tuning of the Optical and Electrochemical Properties of Ruthenium(II) Complexes with 2-Arylbenzimidazoles and 4,4'-Dimethoxycarbonyl-2,2'-bipyridine.

A series of cyclometalated complexes of ruthenium (II) with four different substituents in the aryl fragment of benzimidazole was synthesized in order to study the effect of substituent donation on the electronic structure of the substances. The resulting complexes were studied using X-ray diffraction, NMR spectroscopy, MALDI mass spectrometry, electron absorption spectroscopy, luminescence spectroscopy, and cyclic voltammetry as well as DFT/TDDFT was also used to interpret the results. All the complexes have intense absorption in the range of up to 700 nm, the triplet nature of the excited state was confirmed by measurement of luminescence decay.

Influence of Ligand Environment Stoichiometry on NIR-Luminescence Efficiency of Sm, Pr and Nd Ions Coordination Compounds.

Six new complexes of the ligand HQ (-4-(cyclohexanecarbonyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one) and Ln ions with emission in the near-infrared (Nd) or visible and near-infrared (Sm, Pr) spectral regions were synthesized and characterized using various methods, including single crystal X-ray diffraction. The study demonstrated that both tris complexes [LnQ(HO)(EtOH)] and tetrakis-acids [HO][LnQ] can be synthesized by varying the synthetic conditions. The photochemical properties of the complexes were investigated experimentally and theoretically using various molecular spectroscopy techniques and Judd-Ofelt theory.

[Cost-effectiveness of pneumococcal vaccination among patients with chronic heart failure].

Aim      To analyze the cost-effectiveness of pneumococcal vaccination in 40- and 65-year-old patients with chronic heart failure (CHF).Material and methods  Analysis was performed by Markov modeling from the perspective of the healthcare system. The evaluation was based on Russian epidemiological data taking into account results of international studies.

Dynamics of the Ligand Excited States Relaxation in Novel β-Diketonates of Non-Luminescent Trivalent Metal Ions.

Complexes emitting in the blue spectral region are attractive materials for developing white-colored light sources. Here, we report the luminescence properties of novel coordination compounds based on the trivalent group 3, 13 metals, and the 1-phenyl-3-methyl-4-cyclohexylcarbonyl-pyrazol-5-onate (Q) ligand. [M(Q)] (M = Al, Ga, and In), [M(Q)(HO)] (M = Sc, Gd, and Lu), [Lu(Q)(DMSO)], and [La(Q)(HO)(EtOH)] complexes were synthesized and structurally characterized by a single-crystal X-ray diffraction study.

OLED Structure Optimization for Pure and Efficient NIR Electroluminescence of Nd Complexes Bearing Fluorinated 1,3-Diketones.

NIR emitting OLEDs (organic light-emitting diodes) with high photoluminescence quantum yields were developed on the basis of fluorinated 1,3-diketonate coordination compounds of the Nd ion. Both thermal evaporation and spin-coating techniques were successfully employed for active layer deposition resulting in electroluminescence quantum yields up to 1.38·10%.

Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy.

In temporal lobe epilepsy, high frequency oscillations serve as electroencephalographic (EEG) markers of epileptic hippocampal tissue. In contrast, absence epilepsy and other idiopathic epilepsies are known to result from thalamo-cortical abnormalities, with the hippocampus involvement considered to be only indirect. We aimed to uncover the role of the hippocampus in absence epilepsy using a genetic rat model of absence epilepsy (WAG/Rij rats), in which spike-wave discharges (SWDs) appear spontaneously in cortical EEG.

Yellow to blue switching of fluorescence by the tuning of the pentaphenylphosphole structure: phosphorus electronic state ring conjugation.

The interaction between diphenylacetylene and dichlorophenylphosphine under various conditions is a simple method for the preparation of pentaphenylphosphole derivatives exhibiting fluorescence properties. Depending on the electronic state of the various centers of the phospholic structure, it was possible to obtain molecules with fluorescence, as in the blue area for 1,2,3,4,5-pentaphenyl-2,5-dihydro-phosphole-1-oxide (HPPPO), in the yellow area for 1,2,3,4,5-pentaphenylphosphole-1-oxide (PPPO) and in the cyan area for 1,2,3,4,5-pentaphenylphosphole (PPP). The effect of the structure and π-conjugation on the optical properties of these compounds was studied using PPP derivatives as examples.

Healthcare Workers' Acceptance of COVID-19 Vaccination in Russia.

During the COVID-19 pandemic, the problem of the population's adherence to vaccination has become significantly aggravated around the world. This study is aimed at evaluating healthcare workers' (HCWs) acceptance of COVID-19 vaccination in Russia. A cross-sectional multicenter study was carried out by interviewing HCWs in Russia using an electronic questionnaire and snowball sampling.

Tuning the luminescence efficiency by perfluorination of side chains in Eu complexes with β-diketones of the thiophene series.

A series of europium and gadolinium complexes comprising a β-diketone moiety modified with a fluorinated side-group and thiophene ring have been designed and synthesized and a comparative study of their luminescence properties has been carried out. In this study, when the methyl side group was modified by sequential addition of fluorine substituents and then the perfluorinated carbon chain was extended up to -CF by adding CF fragments, it transpired that the non-radiative energy processes are significantly suppressed in structurally more rigid polyfluorinated β-diketonate compounds of the series as C-H oscillators are replaced with low-energy C-F oscillators. The impact of other electron-withdrawing and electron-donating substituents on the spectroscopic and photophysical properties of the complexes in the present study has also been observed.

Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.

Aims: Intimal hyperplasia is a common feature of vascular remodelling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Current therapeutic approaches including drug-eluting stents are not perfect due to the toxicity on endothelial cells and novel therapeutic strategies are needed.

Novel D-A-D Fluorescent Dyes Based on 9-(-Tolyl)-2,3,4,4a,9,9a-hexahydro-1-carbazole as a Donor Unit for Solution-Processed Organic Light-Emitting-Diodes.

New fluorescent D-A-D dyes containing 9-(-tolyl)-2,3,4,4a,9,9a-hexahydro-1-carbazole as a donor unit and 2,1,3-benzochalcogenadiazoles as an electron-withdrawing group were synthesized. The photoluminescent and electroluminescent properties of novel dyes for fluorescent OLED application were investigated. It was demonstrated that the replacement of lightweight heteroatoms by heavier ones enables the fine tuning of the maximum emission without significantly reducing the luminescence quantum yield.

Mono- and Mixed Metal Complexes of Eu, Gd, and Tb with a Diketone, Bearing Pyrazole Moiety and CHF-Group: Structure, Color Tuning, and Kinetics of Energy Transfer between Lanthanide Ions.

Three novel lanthanide complexes with the ligand 4,4-difluoro-1-(1,5-dimethyl-1H-pyrazol-4-yl)butane-1,3-dione (HL), namely [LnL(HO)], Ln = Eu, Gd and Tb, were synthesized, and, according to single-crystal X-ray diffraction, are isostructural. The photoluminescent properties of these compounds, as well as of three series of mixed metal complexes [EuTbL(HO)] (EuTbL), [EuxGdL(HO)] (EuGdL), and [GdTbL(HO)] (GdTbL), were studied. The EuTbL complexes exhibit the simultaneous emission of both Eu and Tb ions, and the luminescence color rapidly changes from green to red upon introducing even a small fraction of Eu.

Impact of ligand-centered excited states on luminescence sensitization in Pr complexes with β-diketones.

In this study, two novel Pr complexes with different 1,3-diketonate ligands were synthesized and investigated. To study the effect of the ancillary ligand on the energy transfer mechanisms in the complexes, a phenanthroline ligand was introduced. To take into account the influence of the ligand environment composed of different ligands on the energy transfer and relaxation processes, we compared the synthesized compounds with a similar complex containing the phenanthroline ligand.

Sterically hindered phenanthroimidazole ligands drive the structural flexibility and facile ligand exchange in cyclometalated iridium(III) complexes.

A series of bis-cyclometalated iridium(iii) complexes with 2-arylphenanthroimidazole "antenna" ligands containing electron-donor or withdrawing substituents and a more flexible ancillary aromatic β-diketone bearing the "anchoring" carboxymethyl function has been prepared. Thorough X-ray study of the complexes revealed significant structural strains caused by bulky cyclometalated 2-arylphenanthroimidazoles resulting in dramatic distortions of the iridium octahedron and even in twist of the phenanthrene fragment. The crystal data were corroborated by gas-phase DFT calculations whereby the geometry of the complexes was distorted in the same way.

Molecular and Polymer LnM (Ln = Eu, Gd, Tb, Dy; M = Zn, Cd) Complexes with Pentafluorobenzoate Anions: The Role of Temperature and Stacking Effects in the Structure; Magnetic and Luminescent Properties.

Varying the temperature of the reaction of [{Cd(pfb)(HO)}·(pfb)], [Ln(pfb)(HO)]·HO (Hpfb = pentafluorobenzoic acid), and 1,10-phenanthroline (phen) in MeCN followed by crystallization resulted in the isolation of two type of products: 1D-polymers [LnCd(pfb)(phen)]1.5MeCN (Ln = Eu (I), Gd (II), Tb (III), Dy (IV)) which were isolated at 25 °C, and molecular compounds [TbCd(pfb)(phen)] (V) formed at 75 °C. The transition from a molecular to a polymer structure becomes possible because of intra- and intermolecular interactions between the aromatic cycles of phen and pfb from neighboring tetranuclear LnCd fragments.

Near-infrared single-photon emitters based on colloidal CdSe/CdS/ZnS nanocrystals and Nd(III) 1,3-diketonate.

A novel, to the best of our knowledge, approach to the design of the single-photon sources emitting in the spectral regions of 1060 and 1337 nm was developed. A unique hybrid structure based on colloidal CdSe/CdS/ZnS nanocrystals and neodymium(III) 1,3-diketonate was created. Direct energy transfer from the CdSe/CdS/ZnS single nanocrystal to the near-infrared (NIR) luminescent Nd(III) complex was observed and investigated by spectroscopic methods.

Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study.

Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria.

Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation.

Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.

Background Carotid artery intima/media thickness (IMT) is a hallmark trait associated with future cardiovascular events. The goal of this study was to map new genes that regulate carotid IMT by genome-wide association. Methods and Results We induced IMT by ligation procedure of the left carotid artery in 30 inbred mouse strains.

A novel candle light-style OLED with a record low colour temperature.

The possibility of using a single light-emitting layer consisting of newly synthesized fluorescent small organic molecules of D-A-π-A type incorporated into a conductive matrix together with an electron conductive Alq layer in order to form radiation in candle light-style OLEDs was shown for the first time. A record low color temperature of 1722 K OLED radiation was achieved, which is by 80 K lower than that of the best devices reported previously.

The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.

Mutations in natriuretic peptide receptor 2 (Npr2) gene cause a rare form of short-limbed dwarfism, but its physiological effects have not been well studied. Human and mouse genetic data suggest that Npr2 in the kidney plays a role in salt homeostasis. Herein, we described anatomic changes within renal papilla of Npr2 knockout (Npr2) mice.

Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.

Background And Purpose: Sacubitril/valsartan (Sac/val) is more effective than valsartan in lowering BP and mortality in patients with heart failure. Here, we proposed that Sac/val treatment would be more effective in preventing pathological vascular remodelling in 129X1/SvJ (129X1), than in C57BL/6J (B6) inbred mice.

Experimental Approach: Sac/val (60 mg·kg ·day ) and valsartan (27 mg·kg ·day ) were given as prophylactic or therapeutic treatments, to 129X1 or B6 mice with carotid artery ligation for 14 days.

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction of aged marrow macrophages (Mφs) directs HSC platelet-bias. Mφs from the marrow of aged mice and humans exhibited an activated phenotype, with increased expression of inflammatory signals.