Generate and Analyze Three-Dimensional Dendritic Spine Morphology Datasets With SpineTool Software.

Dendritic spine morphology is associated with the current state of the synapse and neuron, and changes during synaptic plasticity in response to stimulus. At the same time, dendritic spine alterations are reported during various neurodegenerative and neurodevelopmental disorders and other brain states. Accurate and informative analysis of spine shape has an urgent need for studying the synaptic processes and molecular pathways in normal and pathological conditions, and for testing synapto-protective strategies during preclinical studies.

Reliability of crowdsourcing as a method for collecting emotions labels on pictures.

Objective: In this paper we study if and under what conditions crowdsourcing can be used as a reliable method for collecting high-quality emotion labels on pictures. To this end, we run a set of crowdsourcing experiments on the widely used IAPS dataset, using the Self-Assessment Manikin (SAM) emotion collection instrument, in order to rate pictures on valence, arousal and dominance, and explore the consistency of crowdsourced results across multiple runs (reliability) and the level of agreement with the gold labels (quality). In doing so, we explored the impact of targeting populations of different level of reputation (and cost) and collecting varying numbers of ratings per picture.

Exploring predictors of life satisfaction and happiness among Siberian older adults living in Tomsk Region.

Despite the growing interest in studying factors affecting subjective well-being of older adults, little research has been conducted on vast territory of Siberia (Russia) with large population. To address this lack of evidence, we explored the relationship between subjective well-being and social aspects (social and emotional support, social network, and social activities), living conditions (standards of living and residence area), self-reported health, and demographic characteristics in older adults living in Tomsk Region, Siberia. Subjective well-being was measured by life satisfaction and happiness (each measured with one 11-point question).

[Severe asthma: Characteristics of patients in clinical practice].

Aim: To provide clinical characteristics of severe asthma (SA) patients encountered in clinical practice.

Subjects And Methods: A cross-sectional cohort study was performed to cover 119 outpatients aged 22-82 years. SA was diagnosed according to the ERS/ATS criteria (2014).

[Method for the determination of the biological age and aging rate in man].

Multiple linear regression was used to develop a mathematical model of biological age in healthy subjects. Aging rate was found to slow down in elderly persons compared with young and middle-aged ones. In men below 60 years, it was lower than in women.

[Left ventricular hypertrophy and thickening of common carotid artery wall in men aged 40 - 54 years with I degree arterial hypertension].

We carried out clinical-instrumental examination of 456 men aged 40-54 years. First degree arterial hypertension was revealed in 165 men. Left ventricular hypertrophy was found in 48 (30%), increased intima-media thickness (IMT) - in 67 (41%) patients.

[Occupational stress as a factor of left ventricular myocardial remodeling in people with normal arterial pressure].

The authors studied correlations between occupational stress, caused by high tension at work, and disturbances in 24-hour arterial pressure (AP), lipid level, and left ventricular (LM) myocardial remodeling in locomotive engineers with normal AP. Two hundred and five locomotive engineers with NAP (according to 2004 classification by Russian Scientific Society of Cardiologists) aged 20 to 45 years were included in this cross-sectional study; the subjects present a whole sample of the locomotive crew of Chelyabinsk railway station. The control group consisted of III persons working eight fixed working hours a day whose work was not associated with high tension (turners and metalworkers).

[Bronchoobstructive syndrome in bronchoectasias].

Aim: To specify mechanisms of bronchial obstruction in bronchoectasia (BE).

Material And Methods: Clinical, x-ray, bronchological and spirographic examinations with broncholytic test were made in 26 BE patients aged 16-66 years (14 males, 12 females). The membrane-receptor complex of erythrocytes was based on the effect of adrenoantagonist propranolol on osmotic erythrocytic resistance (obsidan test) and effect of adrenoagonist adrenalin on dynamics of ESR.

[Risk factors and their influence on chronic respiratory diseases prevalence among population of the Novgorod region].

The authors revealed that actual prevalence of various COLD exceeded the registered value 3.3 times. The actual prevalence appeared to be under influence from tobacco smoking habits distribution, effects of industrial dust pollutants, chronic nasopharyngeal infections, respiratory infections, age, and atmospheric pollution.

[Experience with rovamycin and roxithromycin in patients with chronic bronchitis in the presence of posttuberculous changes].

Rovamycin and roxithromycin were comparatively studied for their effects in 25 patients with chronic bronchitis and posttuberculous changes in the lung. Ten patients received oral rovamycin, 3,000,000 IU, twice daily and 15 had oral roxithromycin, 150 mg, twice daily. The therapy averaged 9 days.

[Characteristics of pneumonia in patients with pulmonary tuberculosis].

In healed tuberculosis, pneumonia more frequently arises in the zones of pronounced residual changes. In active tuberculosis combination of tuberculosis with pneumonia often takes place in intact bronchopulmonary segments. Pneumonia in tuberculous patients takes a lingering course in the presence of pneumosclerotic changes in the lungs, tends to acquire bronchial forms, is characterized by slow involution of inflammation, runs atypically in combination of pneumosclerotic changes in the lungs, bronchial stenoses and abnormal cell composition of bronchoalveolar washout.

[Prevalence of post-tuberculous changes in the bronchopulmonary system in the patients with chronic bronchitis].

The prevalence of chronic nonspecific pulmonary diseases was studied in 1880 industrial workers from Russia. The diseases were reported in 26.5% of the examinees.

[Analysis of lethal outcomes in patients with chronic bronchitis].

A study was made of the clinical data and autopsy protocols of 197 persons who died at a hospital of the machine-building plant. Varying bronchopulmonary pathology was discovered in 129 persons, chronic bronchitis in 80 persons. Patients with CB died in the active period of life.

[The principles of the organization of individualized treatment for bronchial asthma patients].

The authors relate the principles according to which the individualized treatment of bronchial asthma patients may be organized: the permanent treating physician, active participation of the patient in the process of treatment, flexibility of the individualized complex of treatment measures under constant control of the treatment efficacy. Provide the experience gained with such organization of the treatment of 35 patients with grave bronchial asthma ("schools for bronchial asthma patients").

[Status of hemodynamics and its response to exercise in patients with acute pneumonia].

The patients with croupous and focal pneumonia were examined for the response of systemic hemodynamics (HR, SV, MV, BP, PR) to bicycle ergometry in the acute disease period (after temperature normalization, before discharge from hospital and in 6 months following the clinical recovery). Appreciable disorders of the adaptation mechanisms have been demonstrated. They were especially remarkable in the patients with croupous pneumonia and persisted even after 6 months following the patients' discharged from hospital.