Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA.

The theory of computer science is based around universal Turing machines (UTMs): abstract machines able to execute all possible algorithms. Modern digital computers are physical embodiments of classical UTMs. For the most important class of problem in computer science, non-deterministic polynomial complete problems, non-deterministic UTMs (NUTMs) are theoretically exponentially faster than both classical UTMs and quantum mechanical UTMs (QUTMs).

[Use of enterosorption for reducing the biogenic amine content of blood and exudate in peritonitis].

The administration of an enterosorbent prevents increase of the level of biologically active substances in blood and exudate of rats in fecal peritonitis. The results of biochemical and radionuclide methods of examination allow 2 mechanisms of reduction of the histamine and serotonin level in blood and exudate to be distinguished--direct and mediated.

[Sexual function after the surgical treatment of acute epididymitis].

Operative management of acute epididymitis performed in 150 patients aged 18-67 produced better therapeutic results compared to 150 patients treated conservatively (9.1 patient day versus 13.3 days).

[Neuroendocrine aspects of the pathogenesis and treatment of disseminated sclerosis and lateral amyotrophic sclerosis].

Comparative study of neurologic, immunologic, and endocrinologic signs of disseminated sclerosis and lateral amyotrophic sclerosis was carried out by radioimmunoassay, monoclonal antibodies, and microcytotoxic Terasaki's test. The data have shown a tendency to hyperthyroid and hypocorticoid states in 60 percent of lateral amyotrophic sclerosis patients. Fluctuations in hormonal levels of disseminated sclerosis patients were quite the opposite in 37.

[Psychological and psychosomatic prerequisites for the development of duodenal peptic ulcer].

Altogether 276 male patients with duodenal ulcer (DU), 45 with the preulcerative condition (PUC) and 70 with gastroduodenitis were examined. Anxiety-depressive disorders were most frequently revealed in all the groups. The frequency of hypochondriac fixation in DU increased.

[Indices of the body's neurohumoral activity and hemodynamic types in hypertension].

A study of neurohumoral parameters in patients with essential hypertension and different hemodynamic types demonstrated different patterns of hormonal change in patients with hyperkinetic, eukinetic and hypokinetic hypertension. Elevated blood tri-iodothyronine and thyroxine, seen in patients with hyperkinetic hemodynamic type, and increased catecholamine excretion in patients with hypokinetic hemodynamics may be indicative of the pathogenetic significance of the hormones in question for the formation of respective variants of essential hypertension.

[Regional changes in circulation in response to stimulation of beta-adrenergic receptors with isoproterenol].

The muscle and adrenal fractions of cardiac output increased after injection of isoproterenol. The relative blood flow increase in skeletal muscles was accompanied with the increase in regional by-pass blood flow. The latter or reduction in the vessel permeability were found in the lungs.

[Biochemical indices of emotional stress in air traffic controllers].

Air traffic controllers working in automatic and nonautomatic stations showed high values of lipid metabolism parameters as well as significant activation of the sympathoadrenal system (especially, its hormonal component). The level of the parameters under study was correlated with the workload.

[Myocardial blood supply under different degrees of emotional excitation and the pathophysiological characteristics of the mechanisms of its adaptation].

Emotional stress was stimulated by placing rats in a tight cage (moderate stress) or fixing them rigidly on a bench (marked stress) for 1 hour. In moderate emotional stress, the coronary fraction of cardiac output and effective myocardial blood supply declined considerably. Marked emotional stress caused a similar reduction in the cardiac output coronary fraction, whereas effective myocardial blood supply was not reduced, but, on the contrary, tended to increase.

[Participation of sympathetic-adrenal system catecholamines in regulating the reproduction and molting of the hen].

Studies have been made of diurnal changes of adrenalin and noradrenalin content of the blood plasma in egg laying and molting hens. In laying hens at night time, as compared to daily period, the level of both catecholamines decreased, whereas that in molting ones--increased. In laying hens kept under illumination, catecholamine content did not undergo significant diurnal changes.

[Indices of thyroid activity in patients with breast cancer].

An all-round study established thyroid dysfunction in 51 reproductive, climacteric and menopausal patients with primary T2-3 NO-1 MO cancer of the breast. Hypothyroidism is attributed to functional derangement of the thyroid and disorder development in peripheral metabolism.

[Changes in the systemic and regional circulation responses to immobilization stress in the rat after pharmacological sympathectomy].

A preliminary pharmacological desympathization (pirroxan, obzidan, ornid) decreased blood pressure, heart rate, cardiac output, and increased total vascular resistance in immobilized rats. The fraction of cardiac output decreased in lung (bronchial blood flow), liver and myocardium and increased in other organs and tissues. Relative blood supply increased in expansive regions of the skin, muscles and splanchnic organs but decreased in the liver.

[Hypophyseal-adrenal system function in disseminated breast cancer].

The functional condition of the pituitary-adrenal system was studied in 94 patients with disseminated breast cancer. A decreased excretion of 17--OCS's with urine and an increased cortisol level in blood were observed. This was interpreted as relative (extra-adrenal) failure of pituitary-adrenal function in breast cancer patients.

The functional role of the noradrenergic neurons in the thermoregulatory circuits in mice.

Intracerebroventricular (i.c.v.

[Role of hypothalamic monoaminergic structures in regulating sympatho-adrenal system function].

The effect of pharmacological destruction of hypothalamic monoaminergic terminals on the basal and cold stress-induced secretion of neurohormones of the sympathoadrenal system (SAS) in rats was studied. The data obtained on biochemical and histochemical analysis of the hypothalamus (dopamine, noradrenaline and serotonin level, the picture of catecholaminergic terminal fluorescence) were compared with adrenaline and noradrenaline content in blood. It is assumed that function of the SAS is inhibited by hypothalamic noradrenaline and stimulated by dopamine and serotonin under cold stress.

[Functional role of noradrenergic neurons in the hypothermic effect of apomorphine and other dopaminomimetics].

Administration of 6-hydroxydopamine hydrobromide (20-50 mg) into the cerebral ventricles of mice products the depletion of noradrenaline and dopamine in the brain and counteracts the hypothermic effect of dopaminomimetic drugs of direct (apomorphine, piribedil, bromocryptin, CM29-712) and indirect (d, l-amphetamine, L-DOPA) type of action. Pretreatment of animals with the blockers of catecholamines noradrenergic neuronal uptake (desipramine, protryptyline and AW15(1)II29) counteracts both the depletion of noradrenaline in the brain and the antihypothermic effect of 6-hydroxydopamine. The experimental data support the noradrenergic involvement in the hypothermic effect of dopaminomimetics in mice.