[State of the hypophyseal-adrenal system during surgical correction of heart defects under various anesthesiological methods and at distant periods after surgery].

The concentration of 11-HOCS in the blood plasma was measured in 278 patients with heart diseases operated on under various anesthesias at different stages of surgical correction of the defects and in the immediate postoperative period. Plasma ACTH level was measured in 137 of these operated on under deep hypothermia and hypothermal perfusion. The hormonal response was the most expressed in patients operated on under normothermia, whereas in patients exposed to hypothermia the reaction was minimal.

[The state of the hypophyseal-adrenal system during surgical correction of heart diseases under conditions of different anesthesia and in distant periods after surgery].

Blood plasma levels of 11-HOCS were measured in 278 patients with heart diseases operated on under different anesthesia at various stages of surgical correction of the diseases and during the immediate postoperative period. Blood plasma ACTH levels were measured in 137 patients operated on under deep hypothermal protection and hypothermal perfusion. The most manifest hormonal response was observed during surgery under normothermia, whereas under conditions of hypothermal perfusion the reaction to intervention was the minimal.

[Hormonal regulation during cardiac surgery operations on the "dry" heart].

Central and peripheral compartments of hypophyseo-adrenal regulation, the state of renin-angiotensin-aldosterone system (RAAS) and thyroid-stimulating functions of hypophysis have been assessed in 72 patients with heart valve defects operated under profound hypothermal perfusion. It has been established that cardiopulmonary bypass surgery with profound hypothermia is accompanied by moderate and reversible changes in the above parameters. The activity of hypophyseo-adrenal system and RAAS reaches the maximum during a warming-up period and then gradually decreases.