[Necrotizing fasciitis--a clinical model of the department of public health: medicine of critical state].

The article reports the questions, which are associated with the interpretation of disease pathogenesis. The data are based on an analytical generalization of the follow-up study of 59 patients with necrotizing fasciitis in 2003-2011. The main component is stressed: disorders of microcirculation of superficial fascia as a result of thrombosis on basis of the hypercoagulation with outcome to necrosis, which was accompanied with POI syndrome, which manifested with severe form of sepsis (Hardaway theory) and can be considered as main cause of fatal outcome.

[Review of conservative replacement methods of the included minor defects of dentitions].

The paper reports the review of replacement methods of one absent tooth. The study was an assessment of prosthetic work in 275 patients with similar diagnosis. The aim of the study was to compare the indications for different fixed appliances with adhesive bonding on the example of schematic clinical situations.

[Cholangitis and biliary sepsis: problem and ways of solution].

The distinctions and interrelationship were established between acute cholangitis and biliary sepsis. Patients with hyperbilirubinemia were divided into four groups according to the developed criteria of inclusion and of using a new strategy of treatment for each group. It determined the result of treatment, i.

[Quantitative determination of the metabolite level in human urine by NMR 1H spectroscopy].

Conditions for registration of urinary NMR 1H spectra have been optimized in order to achieve maximal accuracy of quantitative analysis. Urinary samples from patients with acute pancreatitis have been investigated. Employment of NMR 1H spectroscopy is perspective for the development of new laboratory diagnostic methods.

[Application of exchangeable transhepatic frame stents in patients with posttraumatic strictures of the hepatic and common bile duct].

For the period from 2000 through 2007 there were 27 patients treated for lesions of extrahepatic bile ducts of different genesis. Since all the lesions were high, we have formed biliodigestive anastomoses on the exchangeable transhepatic drains by the method of Groetz-Saypol-Kurian. In a month after the operation and a standard management of the exchangeable transhepatic drains we departed from the classical technique and applied nonperforated drains.

[The effect of pentoxifylline on the systemic and cerebral hemodynamics in patients with circulatory encephalopathy and an atherosclerotic lesion of the precerebral arteries].

Studied was an effect of pentoxyfilline on systemic and cerebral haemodynamics in 33 patients with discirculatory encephalopathy in the presence of atherosclerotic lesion of the precerebral arteries, with the aid of dye-dilution methods using Evans blue (T-1824) and ultrasonic dopplerography. Pentoxyfilline was found to be associated with significant reduction of the circulating blood volume at the expense of its globular fraction, diminution of the cardiac and stroke work indices; the drug has only minor effects on the peripheral vascular resistance and linear velocity of bloodflow in the precerebral arteries; it makes for an increased number of cases of eukinetic type of blood circulation and causes regression of subjective neurologic symptomatology. On account of its antihypertensive and cardiodepressive effect the drug is contraindicated in patients with low AP and hypokinetic type of systemic haemodynamics.

[The morphofunctional status of the hypothalamo-hypophyseal neurosecretory system and the energy processes in the gastric tissues following electromagnetic irradiation in the millimeter wave range].

A single and double 15 and 30 min exposure to electromagnetic waves of millimetric range (60 GGz, 3 mW/cm2) of a biological active point (acupuncture point) EIII36 of intact male rats and those subjected to stress inhibits the functional activity of hypothalamo-hypophysis neurosecretory system, thyroid gland and cell elements of gastric glands the inhibition being mostly pronounced in animals under stress.

[Integral approach to the prevention of major chronic non-infectious diseases].

The essence and the necessity of an integral approach to prevention of major chronic noncommunicable diseases (CNCD) is described proceeding from the example of the integral CNCD prevention programme in one of Moscow districts. The aims and basic directions of preventive activities are demonstrated along with possible ways of integrating medical services with various district nonmedical institutions. The findings of the sample study of the adult population (25-64 years) of the district are provided.

[Determining the "critical" level of body mass index in dietary preventive programs].

The screening of 709 subjects of both sexes, aged from 16 to 64 years, representing samples from unorganized population was conducted to determine the critical level of body mass index as a criterion for current preventive dietary measures. Anthropometric studies were made, standard questionnaire was used to detect chest pains, ECG at rest was recorded in 12 standard leads using the Minnesota Code. Glucose level in the capillary blood was estimated with the use of "Glucoscot", the levels of cholesterol, triglycerides, HDL cholesterol in the blood serum was assayed in AA-2 ("Technicon").

[Preventive activities of a district physician-internist].

The results of prophylactic examination of a district population were compared with medical documents. Information on 85.7% of patients with CHD, 70.

[Alcohol consumption habits in a population of 40- to 59-year-old men and its prognostic value in relation to mortality].

Alcohol consumption practice was studied by a method of interview in an unorganized male population aged 40 to 59 investigated by a program of multifactorial CHD prevention. The frequency of spreading of this habit and its intensity were determined. The frequency of alcohol consumption was decreased with age and was associated with the examinees' educational level.

[Preventive examination of the population of the medical district of an urban polyclinic].

Prophylactic examination of the population in a district of a city out-patients clinic was performed. Altogether 689 persons (298 men and 391 women) aged 16 to 64 were examined. A great prevalence of chronic non-communicable diseases (CND) and common risk factors were revealed: CHD in 16.

[Neurochemical aspects of therapeutic electric stimulation].

Comparative analysis of the CSF and blood protein-peptide composition in Parkinsonian patients performed with the aid of indwelled electrodes prior to and after therapeutic electrical stimulation (TES) of the brain subcortical structures, revealed a therapeutic effect in the form of reduced muscular rigidity and a mental activation with a positive emotional response. After the TES the protein content in the biological fluids tended to become normalized and the the range of low-molecular protein-peptide fractions changed. A high-performance liquid chromatography, bidimensional electrophoresis and thin-layer chromatography revealed about 5-6 factors of peptide nature with the molecular mass less than 5000 daltons in the CSF and blood after the TES.