rs2228611, rs2228612 and rs2276598, rs752208 Polymorphisms and Their Association with Breast Cancer Phenotype and Prognosis.

: Breast cancer is a leading cause of cancer-related deaths globally. This study investigates the impact of genetic polymorphisms in DNA methyltransferases ( and ) on breast cancer pathomorphology and patient prognosis. Specifically, we focused on polymorphisms rs2228611 and rs2228612 and polymorphisms rs2276598 and rs752208.

Access to diagnostic imaging and radiotherapy technologies for patients with cancer in the Baltic countries, eastern Europe, central Asia, and the Caucasus: a comprehensive analysis.

Background: Only 10-40% of patients with cancer in low-income and middle-income countries were able to access curative or palliative radiotherapy in 2015. We aimed to assess the current status of diagnostic imaging and radiotherapy services in the Baltic countries, eastern Europe, central Asia, and the Caucasus by collecting and analysing local data.

Methods: This Access to Radiotherapy (ART) comprehensive analysis used data from 12 countries: the three Baltic countries (Estonia, Latvia, and Lithuania), two countries in eastern Europe (Moldova and Ukraine), four countries in central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan), and three countries in the Caucasus (Armenia, Azerbaijan, and Georgia), referred to here as the ART countries.

Digital Phenotyping for Monitoring and Disease Trajectory Prediction of Patients With Cancer: Protocol for a Prospective Observational Cohort Study.

Background: Timely recognition of cancer progression and treatment complications is important for treatment guidance. Digital phenotyping is a promising method for precise and remote monitoring of patients in their natural environments by using passively generated data from sensors of personal wearable devices. Further studies are needed to better understand the potential clinical benefits of digital phenotyping approaches to optimize care of patients with cancer.

Development of a Model Based on Delta-Radiomic Features for the Optimization of Head and Neck Squamous Cell Carcinoma Patient Treatment.

: To our knowledge, this is the first study that investigated the prognostic value of radiomics features extracted from not only staging 18F-fluorodeoxyglucose positron emission tomography (FDG PET/CT) images, but also post-induction chemotherapy (ICT) PET/CT images. This study aimed to construct a training model based on radiomics features obtained from PET/CT in a cohort of patients with locally advanced head and neck squamous cell carcinoma treated with ICT, to predict locoregional recurrence, development of distant metastases, and the overall survival, and to extract the most significant radiomics features, which were included in the final model. : This retrospective study analyzed data of 55 patients.

The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer.

(1) Background. Breast cancer is the leading cancer type among women. Despite convenient diagnostics at early stages, there is a need for continuous monitoring to predict more aggressive or recurring breast cancer forms.

The Investigation of Associations between rs1042522, rs2032809, rs9344, rs2227983 Polymorphisms and Breast Cancer Phenotype and Prognosis.

Breast cancer is one of the most common oncological diseases among women worldwide. Cell cycle and apoptosis-related genes , , and play an important role in the pathogenesis of breast cancer. However, the roles of single nucleotide polymorphisms (SNPs) in these genes have not been fully defined.

The impact of mitochondria-related and variants on breast cancer pathomorphological characteristics and patient outcomes.

Purpose: Breast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration.

Associations of and Polymorphisms with Early-Stage Breast Cancer.

Breast cancer is one of the most common cancers worldwide. Single nucleotide polymorphisms (SNPs) in and have been associated with various cancers. However, the influence on clinical characteristics of breast cancer has not been sufficiently investigated yet.

Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis.

Genetic variations in inflammation- and angiogenesis-related genes may alter the coded protein level and impact the pathogenesis of breast cancer (BC). The present study investigated the association of functional single nucleotide polymorphisms (SNPs) in the and genes with the early-stage BC phenotype and survival. Genomic DNA and clinical data were collected for 202 adult Eastern European (Lithuanian) women with primary I-II stage BC.

Use of F-FDG PET/CT Imaging for Radiotherapy Target Volume Delineation after Induction Chemotherapy and for Prognosis of Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

Induction chemotherapy (ICT) before definitive chemoradiation (CRT) gives high response rates in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, pre-ICT gross tumor volume (GTV) for radiotherapy (RT) planning is still recommended. As F-FDG PET/CT has an advantage of biological tumor information comparing to standard imaging methods, we aimed to evaluate the feasibility of F-FDG PET/CT-based post-ICT GTV delineation for RT planning in LA-SCCHN and to assess the prognostic value of PET parameters: maximum standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG).

The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients.

Background: Interleukin-10 and tumor necrosis factor α play an important role in breast carcinogenesis. Genes, encoding those two cytokines, contain single nucleotide polymorphisms, which are associated with differential levels of gene transcription. This study analyzes single nucleotide polymorphisms in interleukin 10 and tumor necrosis factor α genes and their contribution to breast cancer phenotype, lymph node status and survival in a group of young Lithuanian women with early-stage breast cancer patients.

[The comparative study of indicators of immunity and state of pro- and antioxidant systems in patients with chronic pyelonephritis of single kidney in active and latent stages of disease].

It is established that in patients with chronic pyelonephritis of single kidney the antibacterial defense of organism and balance between pro- and antioxidant systems are disturbed both in active and latent stages of disease. The results testify the need of organization of comprehensive immunologic and biochemical examination to establish a prognosis of complications and evaluation of effectiveness of applied treatment.

[Free-radical processes in cardiomyopathy and concomitant vibration disease].

Progression from local vibration to cardiovascular pathology in patients with vibration disease is associated with remodeling cardiac and vascular tissues under effect of oxidative stress. Myocardium and nodular tissue are most vulnerable during development of occupational cardiopathy. Alteration of the heart rhythm wave structure is a predictor of remodeling.

[Neutrophils and antioxidant activity of cervical secretion in women with the acute inflammation in the upper section of the reproductive tract].

The functional activity of neutrophils, peroxidation products and antioxidative activity of cervical secretion in women with the acute inflammatory process in the upper section of the reproductive tract were under study. The most pronounced changes in the function of neutrophils were observed in women with the low antioxidative activity of cervical slime.

[Changes in oxidative processes in the anterior segment of the eye in patients with keratoconus].

Biochemical parameters of the tears, reflecting oxidative processes in the eyes, were analyzed in 79 patients (146 eyes) aged 19-42 years with progressive and acute keratocone and with long remission of the disease. The data indicate disorders in oxidative processes with predominance of aerobic oxidation over anaerobic in the anterior segment of the eye. Evaluation of lipid peroxidation and antioxidant enzymes showed predominance of prooxidant processes over oxidant.

[Lipid peroxidation and antioxidant system parameters in lacrimal fluid in post-traumatic uveitis].

Lipid peroxidation (LPO) values and activities of antioxidant enzymes, catalase, and superoxide dismutase were studied in the lacrimal fluid (LF) of the damaged and intact eyes of 87 patients with posttraumatic uveitis (PTU). Catalase activity was decreased in sluggish PTU and increased in exacerbation, which is attributed to decompensation of the antioxidant system and its effect on the course of posttraumatic inflammation. Similar changes were detected in LF of paired eyes.

[Lipids in the exhaled air condensate of pneumonia patients].

Lipid composition of exhaled air condensate (EAC) was assessed by thin layer chromatography in patients with pneumonia and normal subjects. In parallel with this, diene conjugates and diene ketones were assessed by spectrophotometry. Berhan's principle was for the first time used for noninvasive obtaining of EAC from each lung separately.

[Modification of the determination of lipid peroxidation products in a reaction with thiobarbituric acid].

The aim of the study was to choose the optimal conditions for spectrophotometry of the blood serum lipid peroxidation (LPO) products by the thiobarbituric acid (TBA) test. LPO products have been measured in trichloroacetic acid filtrate and in lipoprotein sediment by spectrophotometry and fluorometry. The optimal conditions for spectrophotometry of TBA-active LPO products are as follows: the proteins are sedimented with 20% solution of phosphotungstic acid, stabilizing the pH values in 1.

[Features of the morphofunctional state of the organs of the thymico-lymphatic system during various adaptive reactions induced by electric stimulation of emotiogenic structures of the brain].

Weak electrical stimulation of emotiogenic brain structures was found to lead to the development of different general non-specific adaptation reactions. Stimulation of nucleus lateralis septi was found to evoke mainly the development of activation reaction, while stimulation of globus pallidum caused primarily the development of training reactions. Stress reactions were considerably less frequent in electrical stimulation of both kinds of structures than in the control.

[Dynamics of alpha1-antitrypsin and alpha2-macroglobulin in patients with acute and chronic pneumonia].

Content of alpha 1-antitrypsin and alpha 2-macroglobulin was studied in blood serum of patients with acute and chronic forms of pneumonia. Within the first decade of the disease alpha 1-antitrypsin was more distinctly increased in the patients with chronic pneumonia. Stable elevation of alpha 1-antitrypsin correlated with long-term presence of the inflammation symptoms.