Publications by authors named "Kornilov V"

The development of new techniques for characterizing atmospheric optical turbulence (OT) has become an active topic of research again in recent years. In order to facilitate these studies, we reconsidered known theoretical results and obtained some new practically useful conclusions. We introduce a dimensionless Fresnel filter, which allows us to approximate a polychromatic weighting function (WF) by a monochromatic one with a typical precision of several percent.

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Objective: To search for correlations between platelet cytochrome c-oxidase (COX) activity and the quality of therapeutic outcomes and other clinical parameters of depression in elderly patients.

Material And Methods: Twenty elderly women, aged 55-78 years, with depressive episodes in recurrent depressive disorder (RDD) or bipolar affective disorder (BD) were studied. COX activity and severity of depression were evaluated twice: before the beginning of antidepressant treatment and at the 28-th day of the therapy, using the Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAM-A).

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Aim: Comparative evaluation of the efficacy and safety of antidepressant monotherapy and complex antidepressant therapy in combination with carnicetine in the treatment of depression in elderly patients in a psychiatric hospital.

Material And Methods: Two groups of hospitalized patients, aged from 60 to 79 years, with mild or moderate depression (according to ICD-10), comparable in basic demographic and clinical characteristics, received mono- or complex (in combination with carnicetine) antidepressant therapy for 8 weeks. Treatment efficacy was assessed with HAM-D, HARS, CGI-S and CGI-I; the level of cognitive activity was assessed with MMSE, the 10-word memory test and clock drawing test.

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Newly formed black holes of stellar mass launch collimated outflows (jets) of ionized matter that approach the speed of light. These outflows power prompt, brief and intense flashes of γ-rays known as γ-ray bursts (GRBs), followed by longer-lived afterglow radiation that is detected across the electromagnetic spectrum. Measuring the polarization of the observed GRB radiation provides a direct probe of the magnetic fields in the collimated jets.

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Article Synopsis
  • A study compared the effectiveness and safety of modern antidepressants (venlafaxine, agomelatine, fluvoxamine) alone versus in combination with acetyl-L-carnitine in older adults with depression.
  • Two groups of elderly patients (ages 60-79) with mild to moderate depression were treated for 8 weeks, either with just the antidepressant or along with carnicetine.
  • The findings indicated that the combination therapy was more effective, showed faster improvements in symptoms like depression and anxiety, and resulted in fewer side effects, suggesting it could be a better treatment option for older patients.
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In this work we use the alternative method of assessing the EEG-synchrony which previously has proved its high sensitivity to the differentiation of psychopathological and functional states. The original recording of EEG had been performed in the state of quiet wakefulness with eyes closed for two groups of examinees/patients at the age of 49-82 years: a group of normal subjects (n = 29) and the group of subjects with depressive deviations of F43.21 category according to ICD-10 (n = 51).

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Article Synopsis
  • The study evaluated how effective and safe valdoxan (agomelatine) is for treating depression in elderly patients at a psychiatric hospital.
  • The research included 20 patients over 60 years old, who took valdoxan for 42 days at doses of 25-50 mg/day.
  • The results showed that valdoxan significantly improved symptoms of depression, anxiety, and cognitive function, making it a promising treatment option for mild to moderate depression in elderly inpatients.
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Many physical experiments require analysis of the statistics of fluctuating radiation. In the case of an ideal single-photon detector, the contribution of photon noise to the statistics of the registered signal has been thoroughly examined. However, practical photon counters have a dead time, leading to miscounting of certain true events, and sometimes the counters generate false afterpulses.

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To reveal neurophysiological correlates of treatment efficacy of late onset depression, EEG spectral power, peak latencies of the "late" components of auditory cognitive evoked potentials, and sensorimotor reaction time have been analyzed in two groups of elderly patients, aged 53-72 years, with prolonged psychogenic depressive reaction (F43.21 by ICD-10) and with endogenous depression (F33.1 and F31.

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With the aim of justifying of neurophysiological correlates of depressive disorders spectral parameters of EEG, and peak latencies of the "late" components of auditory cognitive evoked potentials, and latencies of sensorimotor reactions have been analysed in middle age and elderly patients (age 53-72) during the therapy of prolonged psychogenuously provoked depressive reaction (F43.21 by ICD-10). Background depression severity has been associated with the EEG signs of decreased functional state of anterior areas of the left hemisphere, and of increased activation of the right hemisphere (especially, of its temporal regions).

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Bipolar electrodes were implanted in the lateral hypothalamus in a group of 44 Wistar male rats in order to study self-stimulation reaction in the Skinner box. Simultaneously, microcanules were implanted into the central nucleus of the amygdala to inject the drugs (1 microl per injection). The blockade of corticoliberin (CRF) receptors (astressin, 1 microg) or Na+influx currents (xycaine or lidocain 1 microg) by the intrastructural administration of drugs into the amygdala decreased self-stimulation reaction of the lateral hypothalamus in rats by 29-55%.

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Theoretical relations were obtained to calculate the correlation of stellar scintillation, when a star is measured simultaneously in two different photometric bands (channels). Differential color scintillation and the respective indices are proposed for practical evaluation of the correlation. Asymptotic dependence for the case of an infinitely small receiving aperture is derived and analyzed.

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Molecular dynamics computer simulations of hydrated bilayers of unsaturated phosphatidylcholines in which double bonds are in the states: 18:0/18:1(n-9)cis (PC), 18:0/18:2(n-6)cis (PC), 18:0/18:3(n-3)cis (PC), 18:0/20:4(n-6)cis (PC), and 18:0/22:6(n-3)cis in the presence of cholesterol (40 mol%) and its absence have been performed. The simulation have been performed at 303 K and 1 atm, under the conditions corresponding to the experimentally observed liquid-crystalline state of the bilayer from phosphatidylcholine. The C-C and C-H bond order parameter profiles with respect to the bilayer normal and the C-C bond orientation distribution functions have been calculated.

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Molecular dynamics (MD) computer simulations of five different hydrated unsaturated phosphatidylcholine lipid bilayers built up by 18:0/18:1(n-9)cis PC, 18:0/18:2(n-6)cis PC, 18:0/18:3(n-3)cis PC, 18:0/20:4(n-6)cis PC, and 18:0/22:6(n-3)cis PC molecules with 40 mol% cholesterol, and the same five pure phosphatidylcholine bilayers have been performed at 303 K. The simulation box of a lipid bilayer contained 96 phosphatidylcholines, 64 cholesterols, and 3840 water molecules (48 phosphatidylcholine molecules and 32 cholesterols per layer and 24 water molecules per phospholipid or cholesterol in each case). The lateral self-diffusion coefficients of the lipids in these systems and mass density profiles with respect to the bilayer normal have been analyzed.

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The multiaperture scintillation sensor (MASS) has become a device widely employed to measure the altitude distribution of atmospheric turbulence. An empirical study is reported that investigates the dependence of the MASS results on the knowledge of the instrumental parameters. Also, the results of a side-by-side comparison of two MASS instruments are presented, indicating that MASS instruments permit measurements of the integrated seeing to a precision better than 0.

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It was shown that agents inducing phagocytosis (zymosan, lectins) cause changes in the number of receptors responsible for fast neutrophil reaction (chemotaxis or respiratory burst) or inhibit the binding of the agonist to its receptor. Among lectins are ribosome-inactivating proteins of type II ricin and agglutinin ricin, which penetrate the cell by binding to mannose and galactose receptors. It was shown that ribosome-inactivating proteins of type II can exhibit the properties of the antagonist of the receptor N-formylmethionylleucylphenylalanine.

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The ability of viscum at different concentrations to modulate the respiratory burst in neutrophils, induced by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine was studied. This does not exclude the possibility that viscum can interact with the receptor of this peptide. The analysis of the primary structure of viscum revealed elements structurally analogous to the chemotactic peptide.

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The crystal structure of the ribosome-inactivating protein (RIP) mistletoe lectin I (ML-I) from Viscum album has been solved by molecular replacement techniques. The structure has been refined to a crystallographic R-factor of 24.5% using X-ray diffraction data to 2.

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Despite the existing differences in medical care of war and catastrophe casualties it is possible to apply a variety of organizational and management principles of military medicine for the disaster medicine. The authors express the opinion that in case of big catastrophes the medical service could operate by means of rapid deployment units formed on the basis of territorial principle.

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The mutagenicity of 14 samples of Don river delta water was studied by the Ames test and the technique of estimation of Drosophila dominant lethals. Experiments revealed that mutagenic pollution of Don river delta water was total at least in April--May 1989.

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A dynamic model for quaternary structure of a multienzyme complex is considered. The model is based on the supposition of simultaneously existing similar subunits in a number of different conformational states in the "core" of the multienzyme complex. It is supposed that cyclic conformational transitions of the "core" subunits conserve the symmetry of the entire complex.

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