Publications by authors named "Korkmaz F"
Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure and water homeostasis, it also modulates diverse social behaviors, such as pair-bonding, social recognition and cognition in mammals including humans. Importantly, AVP modulates social behaviors in a gender-specific manner, perhaps, due to gender differences in the distribution in the brain of AVP and its main receptor AVPR1a.
View Article and Find Full Text PDF-rearranged (r) leukemia is characterized by a poor prognosis. Depending on the cell of origin, it differs in the aggressiveness and therapy response. For instance, in adults, volasertib blocking Polo-like kinase 1 (PLK-1) exhibited limited success.
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- High levels of follicle-stimulating hormone (FSH) in post-menopausal women are linked to the development of Alzheimer's disease (AD), as shown by studies in mice.
- Mice lacking FSH receptors displayed improved spatial memory, indicating that blocking FSH signaling can help prevent memory loss related to aging and AD-like pathology.
- The findings suggest that targeting FSH could be a potential strategy for preventing memory deficits in post-menopausal women.
Article Synopsis
- This meta-analysis examined the relationship between specific gene polymorphisms and endurance athlete performance, focusing on five genes believed to influence physical performance and related biological processes.
- A total of 20 relevant studies published from 2009 to 2023 were analyzed after screening 329 articles for eligibility based on specific criteria.
- Findings revealed no significant differences in allele and genotype frequencies between endurance athletes and control groups for most genes, but the results for the gene rs12594956 were noted as distinct.
Aim: The study was conducted to determine nurses' experiences with electronic patient record systems and their suggestions for incorporating them into undergraduate nursing education.
Background: The integration of computers into healthcare represents one of the most significant developments of the 21st century. Understanding nursing professionals' experiences with electronic patient record systems and the innovations they seek in teaching can provide effective methods for training future users.
ProAKAP4 is a sperm structural protein that regulates motility through the PKA-dependent cAMP signaling pathway, which is synthesized as an X chromosome-linked member of the gene family. This study aims to determine the optimal level of proAKAP4 for evaluating sexed semen through investigating its relationship with the longevity of sperm quality in sexed Holstein bull sperm. A total of 30 sexed sperm samples (bearing X chromosomes) from 30 distinct Holstein bulls ( = 30) were analyzed.
View Article and Find Full Text PDFInvariant natural killer T (iNKT) cells are a small fraction of T lymphocytes with strong cytotoxic and immunoregulatory properties. We previously showed that human culture-expanded iNKT cells prevent alloreactivity and lyse primary leukemia blasts. Here, iNKT cells have several advantages over T cells based on their immunoregulatory capabilities.
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- The last ten years have greatly improved our knowledge of bone health and the processes behind bone loss in osteoporosis, both primary and secondary.
- Key discoveries have come from studying bone diseases in people and creating similar conditions in genetically altered rodents, revealing that pituitary hormones play important roles in bone health beyond just affecting other hormone-producing glands.
- Specific hormones like follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) have been linked to rapid bone loss during menopause and thyroid issues, respectively, while hormones like oxytocin and prolactin may influence bone health across generations.
Aim: This study aims to capture the perspectives of senior undergraduate nursing students concerning pressure injury risk assessment, shedding light on their practical experiences and insights.
Background: Pressure injuries pose a significant challenge in healthcare, demanding vigilant attention from healthcare professionals. Central to mitigating this challenge is the imperative role of risk assessment, placing nurses at the forefront of prevention strategies.
Article Synopsis
- The sympathetic nervous system (SNS) plays a significant role in regulating bone metabolism, with abundant SNS innervation found in the periosteum and bone marrow, consisting of specific nerve fibers.
- Using a viral tracing method, researchers have identified 87 specific brain nuclei that send SNS signals to bone, revealing the complexity of this neural connection.
- Certain brain areas, like the raphe magnus and periaqueductal gray, show higher levels of SNS activity, emphasizing the importance of these sites in understanding bone metabolism and pain regulation.
Purpose: Case reports of subacute thyroiditis (SAT) following coronavirus disease-19 (COVID-19) have been reported. Because the relationship between SAT and human leucocyte antigen (HLA) alleles is known, we aimed to determine HLA alleles that may predispose a patient to coronavirus infection and/or post-COVID-19 SAT.
Method: This retrospective study was conducted in 51 patients with SAT and 190 healthy bone marrow donor volunteers.
Pneumonia persists as a public health crisis, representing the leading cause of death due to infection. Whether respiratory tract infections progress to pneumonia and its sequelae such as acute respiratory distress syndrome and sepsis depends on numerous underlying conditions related to both the causative agent and host. Regarding the former, pneumonia burden remains staggeringly high, despite the effectiveness of pathogen-targeting strategies such as vaccines and antibiotics.
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- Angiogenesis is the formation of new blood vessels, essential for tissue health and involved in conditions like tumor growth and inflammation.
- This study focuses on the compound FDI-6 and its unexplored connection to angiogenesis, particularly its impact on VEGF-B protein expression and interaction with the VEGFR1 protein, crucial for initiating angiogenesis.
- Results indicate FDI-6 has distinct cytotoxic effects on different cell types and regulates VEGF-B expressions, promoting future research into its potential as a therapeutic agent in angiogenesis-related diseases.
Article Synopsis
- The study aimed to investigate dermatological lesions linked with chronic itching (pruritus) in patients with type 1 and type 2 diabetes mellitus (DM) who visited a clinic.
- Out of 249 patients, 30.9% reported experiencing pruritus, and this group showed significantly higher rates of various complications like neuropathy and retinopathy compared to those without pruritus.
- Common skin issues found included xerosis (dry skin) and fungal infections, highlighting that chronic itching in diabetics may relate to poor health management and could warrant reevaluation of their medications.
Background: The research about sustainable and alternative plant protein sources has accelerated with the increasing need for protein. Safflower meal has a potential to be used in protein production due to its high protein content. This research aimed to produce an alternative plant-based protein powder using safflower meal.
View Article and Find Full Text PDFPatients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STING mutation (VM). Prior radiation chimera studies revealed an unexpected and critical role for non-hematopoietic cells in initiating ILD. To identify STING-expressing non-hematopoietic cell types required for the development of ILD, we use a conditional knockin (CKI) model and direct expression of the VM allele to hematopoietic cells, fibroblasts, epithelial cells, or endothelial cells.
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- The pituitary gland secretes tropic hormones that regulate various endocrine organs and are involved in functions like skeletal modeling, metabolism, and cognitive processes.
- Hormones like FSH, traditionally known for their role in reproductive health, also play significant roles in fat and bone metabolism as well as cognition.
- Research shows that understanding the broader functions of FSH may lead to new therapeutic options for health issues related to menopause, including osteoporosis, obesity, and dementia.
Locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis. The introduction of PD-1 inhibitors has led to a significant improvement in survival, but only a subpopulation of patients responds to therapy. Current biomarkers cannot reliably identify these patients.
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- Alzheimer's disease (AD) is linked to high levels of follicle-stimulating hormone (FSH) in post-menopausal women, which may trigger memory loss and AD-like symptoms in mice.
- A study tested different groups of female mice (some unoperated, some with surgery, and some undergoing ovariectomy) and found that gene-deletion of FSH receptor (Fshr) improved spatial memory and recognized memory, highlighting a gene-dose effect.
- Overall, the research suggests that lower FSH levels could have protective benefits against memory loss associated with aging and AD, as indicated by better memory retention in mice with reduced FSH signaling.
Musculoskeletal and neurocognitive clinical significance of adult hypophosphatasia.
Osteoporos Sarcopenia
December 2023
Hypophosphatasia (HPP), also called Rathbun disease, is a rare genetic disorder that is caused by the loss-of-function mutation in the gene encoding tissue non-specific alkaline phosphatase. Doctor Rathbun first described the case of a 3-week-old infant who presented with severe osteopenia, rickets, and multiple radiographic fractures, and died shortly after of epileptic seizure and respiratory distress. The term "hypophosphatasia" was coined as the patients' alkaline phosphatase levels were significantly low.
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- The sympathetic nervous system (SNS) plays a significant role in bone metabolism, with nerves found in the periosteum and bone marrow showing evidence of noradrenergic fibers.
- Recent research using pseudorabies (PRV) tracing has identified 87 brain nuclei that send efferent SNS signals to bone, highlighting the complexity of this communication.
- Specific regions, like the raphe magnus and periaqueductal gray, exhibit varying levels of SNS activity, leading to new insights into how these neural pathways could be linked to bone health and pain management.
Article Synopsis
- Relapse and graft-versus-host disease (GVHD) are major causes of death after hematopoietic cell transplantation (HCT), and invariant natural killer T (iNKT) cells may help prevent GVHD while fighting malignancies.
- This study aimed to enhance the effectiveness of iNKT cells by creating CD19-CAR-iNKT cells that target lymphoma while maintaining their immune-regulatory properties.
- Results showed that while CD19-CAR-iNKT cells can induce target cell death, they also face exhaustion; however, using checkpoint inhibitors like nivolumab boosted their effectiveness and reduced the risk of GVHD.
Article Synopsis
- This study aimed to investigate the role of human leukocyte antigens (HLA) in the recurrence and development of subacute thyroiditis (SAT) within the Turkish population, involving 51 SAT patients and 720 healthy volunteers.
- Various HLA alleles were genotyped, revealing certain subtypes significantly associated with increased risk of developing SAT and distinguishing between relapsing and non-relapsing cases.
- The findings suggest that specific HLA subtypes, including some identified as risk factors, could influence both the likelihood of SAT recurrence and its overall susceptibility in individuals.