Publications by authors named "Korkmaz C"
Article Synopsis
- - Mushrooms are nutritious with high protein and healthy fats, and they are being researched for their health benefits and potential industrial applications, particularly their natural compounds.
- - The study explored the cytotoxic effects of different extracts from the mushroom on various cancer cell lines using various scientific assays, finding that the hexane extract was most effective against A549 cells, while methanol extract showed considerable efficacy against PC-3 cells.
- - Additionally, the methanol extract exhibited strong antioxidant activity and reduced inflammatory markers (like TNF-α and VEGF), while the hexane extract displayed notable antimicrobial properties against several pathogens.
Article Synopsis
- The research focuses on the benefits of natural product-based therapies, particularly emphasizing the healthful properties of a common spice used in Algeria, (L.) Ach., through various extract evaluations.
- Key findings revealed the presence of significant phenolic compounds such as rosmarinic acid and caffeic acid, alongside strong antioxidant and anti-inflammatory activities linked to both aqueous and methanolic extracts.
- The methanolic extract demonstrated notable cytotoxic effects on human cancer cells while showing no harm to non-tumor cells, suggesting its potential as a natural therapeutic agent.
Background: Cystic fibrosis (CF) is a multisystemic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective synthesis or function of the CFTR protein. Historically, CF treatment focused on managing symptoms and complications. Fortunately, modulator drugs are now available to directly target the defective CFTR protein.
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- * Researchers collected 1,346 nasopharyngeal swab samples, isolating 879 high-quality genomes for analysis, focusing on clades, lineages, age-related associations, and mutations over a 10-month period.
- * Specific variants like B.1.1.7 (Alpha) and B.1.617.2 (Delta) were identified, along with unique mutations linked to the later Omicron variant, emphasizing the need for ongoing genetic monitoring to improve COVID-19 prevention strategies.
Background/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address.
View Article and Find Full Text PDFTocilizumab (TCZ) which is a humanized interleukin (IL)-6 receptor antibody has been increasingly widespread used in rheumatology practice. TCZ-related hypofibrinogenemia is a not well-described side effect, but awareness seems to be incresing as publications on this topic are also becoming more frequent. Our aim in this study was to determine the frequency, timing, and approach to TCZ-related hypofibrinogenemia in rheumatic diseases.
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- The study aimed to explore the incidence and risk factors of venous thromboembolism (VTE) in hospitalized patients with hematologic cancers to understand their higher risk of thrombosis.* -
- An analysis of 94 patients showed a 11.7% incidence of superficial vein thrombosis and 7.4% for deep vein thrombosis, with those who developed thrombosis experiencing longer hospital stays and more frequent admissions.* -
- The findings highlight the need for a standardized risk scoring system to effectively identify patients with multiple risk factors to improve thrombosis prevention strategies.*
Immune-checkpoint inhibitors (ICIs) are considered as the novel treatment modality in certain cancers. They may soon be used widely even as the first-line option for cancer treatment due to their remarkable efficacies and impacts on survival rates, particularly in cases of advanced metastatic cancer. Of note, these agents might unveil new autoimmune diseases as well as causing flare-ups of a pre-existing autoimmune disease.
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- Systemic lupus erythematosus (SLE) significantly increases the risk of cardiovascular disease, prompting a study to evaluate traditional cardiovascular risk factors in SLE patients worldwide between 2015 and 2020.
- The study included 3,401 SLE patients from 24 countries, predominantly women, revealing high rates of hypertension (35.6%), obesity (23.7%), and hyperlipidaemia (19.8%), with poor control of these risk factors across the board.
- Notably, patients with antiphospholipid syndrome had higher prevalence of cardiovascular risks but showed better control of blood pressure and lipid levels compared to those without, highlighting international discrepancies in risk factor management.
Article Synopsis
- Dermatomyositis (DM) is a rare inflammatory disease that affects the skin and muscles, and spontaneous intramuscular hemorrhage (SIH) is a severe but uncommon complication associated with it.
- A study analyzed DM patients from a university hospital over 26 years to assess the frequency and risk factors of SIH, identifying a sample of 42 patients, predominantly female (76.2%), with an average age of 53.
- Key risk factors for developing SIH included male sex, presence of interstitial lung disease (ILD), specific antibody positivity (anti-MDA5 and anti-Ro52), use of heparin, treatment with intravenous immunoglobulin, and higher steroid doses.
Humor can contribute to nursing practices for relieving pain and anxiety in patients with rheumatoid arthritis (RA) during intravenous (IV) biologic treatment. This study used a prospective, randomized controlled study design to investigate the effect of humor on pain and state anxiety in patients with RA receiving IV infusion therapy. Two sample groups were formed: the intervention group (watching a comedy movie) (n = 18) and the control group (usual care) (n = 18).
View Article and Find Full Text PDFThe objective of this study was to assess the pregnancy outcomes in a cohort of patients who experienced pregnancies before and/or after being diagnosed with Takayasu's arteritis (TA). The present investigation encompassed a total of 88 pregnancies seen in a cohort of 35 patients who met the criteria outlined by the American College of Rheumatology in 1990 for the classification of Takayasu arteritis (TA). Pregnancies were classified into two categories.
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- The study investigates how different production techniques for metal frameworks in metal-ceramic restorations impact their color.
- The research used 45 samples produced via casting, milling, and laser-sintering, measuring color changes at various application stages with a spectrophotometer.
- Significant differences in color (L*, a*, b* values) were found between the different production methods, highlighting that the technique chosen can affect the final aesthetic outcome of the restoration.
Objective: The objective of this study was to evaluate the effects of parental anxiety, depression levels and psychiatric symptom profiles of parents on the occurrence of sleep bruxism in children.
Material & Methods: This cross-sectional study was carried out with a sample of 94 children aged 6 to 12 years, divided into two groups: with sleep bruxism (bruxism group-BG) and without sleep bruxism (control group-CG). Beck Depression Inventory (BDI), Symptom Checklist (SCL-90-R), Symptom Checklist and Screen for Child Anxiety Related Emotional Disorders-Parent (SCARED-P) scale were used to assess anxiety and depression levels of parents.
Background: The Coronavirus Disease (COVID-19) outbreak has caused especially health workers to face mental and physical problems all over the world. The aim of this study is to evaluate burnout, stress perception and perceived social support levels of clinical (the fourth and fifth year) dental students during the COVID-19 pandemic.
Methods: The Sociodemographic Information Form (SIF), Maslach Burnout Inventory (MBI), Sense of Coherence-13 (SoC-13), Perceived Stress Scale-10 (PSS-10), and Multidimensional Scale of Perceived Social Support (MSPSS) were used for data.
Edible mushrooms are important providers of nutrients and are well recognized for their particular organoleptic properties. The volatiles that releases serve purposes beyond simply appealing to our sense of smell. Truffles have different smells and tastes due to the fact that they contain different volatile components; therefore, aroma is essential in defining the organoleptic properties and quality of truffles.
View Article and Find Full Text PDFIgG4-related disease (IgG4-RD) is a fibroinflammatory condition that is characterized by storiform fibrosis, infiltration of IgG4-positive lymphocytes, obliterative phlebitis, and high IgG4 levels. Since IgG4-RD affects a wide variety of organs, a differential diagnosis must include multiple conditions. IgG4-RD is also believed to coexist with certain diseases.
View Article and Find Full Text PDFWe aimed to compare repeated LPP (luteal phase oestradiol LPP/GnRH antagonists protocol) treatment with different protocol results with poor ovarian response (POR) patients. Two hundred and ninety-three cycles with poor ovarian reserve who underwent LPP, microdose flare up protocol and antagonist protocol were included in the study. Of these, 38 patients were applied LPP in the first cycle and LPP in the second cycle.
View Article and Find Full Text PDFThe genes that drive development each typically have many different enhancers. Properly coordinating the action of these different enhancers is crucial to correctly specifying cell-fate decisions, yet it remains poorly understood how their activity is choregraphed in time. To shed light on this question, we used recently developed single-cell live imaging tools to dissect the regulation of Fushi tarazu (Ftz) in Drosophila melanogaster embryos.
View Article and Find Full Text PDFPurpose Of The Study: The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19.
Study Design: In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors.
Background: The coronavirus disease-2019 (COVID-19) pandemic has caused healthcare professionals to face unequal acute workplace stress and burnout. This study aimed to analyze the potential impact of COVID-19 on the burnout and associated emotional stress conditions of Turkish dental technicians.
Methods: A 20-question demographic scale, Maslach Burnout Inventory (MBI), Sense of Coherence-13 (SoC-13), and Perceived Stress Scale-10 (PSS-10) were used to obtain data.
Background: The roughening of the inner surface of a fixed ceramic restoration is an important factor for the bonding process. The aim of this study is to investigate the effect of combined surface treatments (acid etching, air-abrasion and Er: YAG Laser) on surface roughness of CAD/CAM fabricated zirconia (ZrO) and lithium-disilicate glass ceramics (LDS).
Methods: Sixty ZrO (Ceramill Zi) and LDS (IPS e.