Publications by authors named "Korina J Steinbergs"
J Clin Invest
November 2024
Article Synopsis
- Activating transcription factor 6 (Atf6) is crucial for managing the unfolded protein response (UPR) and maintaining proper endoplasmic reticulum function, with loss of ATF6 linked to vision issues like achromatopsia.
- Some patients with ATF6 mutations also experience progressive sensorineural hearing loss, which was mirrored in Atf6-/- mice showing auditory deficits and structural damage in their cochleae.
- The research highlights the role of ATF6 in cochlear health and suggests that ER stress is a critical factor in hearing loss, indicating the need for adjustments in patient lifestyles to reduce ear-related stressors.
