ABO system combination with Rh, Kell and MN group in Georgian blood donors.

Unlabelled: There are numerous scientific data about the study of the prevalence of blood group antigens in the different donor population. Several studies showed that the profile of major blood group antigens is not similar in blood donors from different local areas.

Research Objective: Our scientific goal was to study of the prevalence blood group antigens in the Georgian blood donor population.

Specific Combinations of Erythrocyte Group Antigens in Blood Donors.

Blood groups are inherited biological characteristics that do not change throughout life only in healthy people. Blood group antigens determine the adaptation of a human, as a biological species, to the surrounding environment. Our goal was to study the combination and frequency characteristics of three group systems (ABO, RH, KELL) in blood donors.

Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients.

Methylenetetrahydrofolate reductase ( MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comparison with healthy individuals and its association with arterial thrombosis. We enrolled 214 participants: 101 with arterial thrombosis (71.

SMOKING INCLINED GROUPS ACCORDING TO THE PHENOTYPE OF THE PTC GENE.

The ability to sense phenylthiocarbamide (PTC) bitterness represents a well-known and convenient genetic marker for human populations and biomedical studies. Two basic phenotypes can be dichotomized by PTC sensitivity: PTC-sensitive or "tester" and PTC-insensitive or "non-tester". The majority of the population (approximately 70%) belong to the PTC-sensitive phenotype, while the remaining 30% are PTC-insensitive.

The association of some genetic factors with pulmonary tuberculosis in Georgian and Azeri ethno groups.

Pulmonary Tuberculosis (TB) is still one of the major public health problems. Over the last half decade the significant problem is an increased ratio of drug-resistant TB cases. TB is as well the most significant infectious disease in the country of Georgia.

Study of some biogerontological factors associated with women longevity in Ajara population.

120 long-living women have been studied in Ajara with the purpose of revealing biogerontological factors associated with longevity. On the basis of special gerontological questionnaire survey and the genealogical research it has been revealed that the absolute majority of the long-livers was in happy and long marriage, most of them had stable partners and were in happy and long marriage. There are early as well as late marriages among the long-livers.

Composition of erythrocytic (ABO, Rh-Hr, Kell, MN) group antigens characteristic of the Ozurgeti district's population.

Erythrocytic group antigens represent a genetically stably determined trait. Investigation of antigens of the said system in different regions is of the greatest importance in terms of both the creation of demographic data of the region as well as practical medicine, especially for transplantology and transfusiology. The peripheral or venous blood of 232 local natives (healthy donors) of Ozurgeti district of Guria region has been taken as the test subject.

Gerontology research in Georgia.

Gerontology research carried out in different scientific centers of Georgia follows the basic directions of most work in this field: epidemiology, investigation of the mechanisms of aging, and finding ways to prevent senile pathologies and to prolong life. The genealogy and epidemiology of long-living peaple have been studied in areas with high occurrence of these people by considering the sex ratio and social status of the long-living, the influence of environmental factors, and the development of senile pathologies. According to the centrosome (centriole) model of aging, the centrosomes and the cytoskeleton, important structures in cellular differentiation and morphogenesis, may be involved in the initiation of the replication senescence mechanism.

Biogerontologic study of population in some districts of Ajara Autonomous Republic.

The study of genetic markers of aging is of current importance in gerontology. Data of long-liver residents of Ajara Autonomous Republic have been investigated with the aim of establishing genetic markers associated with longevity. 10 blood antigens - A, B, C, c, D, E, e, K, M, N of ABO, Rh-Hr, K, MN blood group systems have been investigated.

Effect of multiple generalized seizures on the wakefulness-sleep cycle.

This paper gives the results on the studies of the effect of multiple generalized seizures (MGSs) on the wakefulness-sleep cycle (WSC). The adult Wister rats served as the experimental objects. The animals, under chloral hydrate anesthesia (35-40mg/kg) were stereotaxically implanted with stainless metal electrodes aimed into the neocortex and dorsal hippocampus.

[Effect of deprivation of paradoxical sleep on retention of the "passive" avoidance response].

The effect of paradoxical sleep deprivation on the retention of passive avoidance was studied in rats. The analysis of the data obtained shows that paradoxical sleep deprivation produces impairment of the criterian of passive avoidance retention, latency prolongation of this reaction and augmentation of rat's motor activity in open field. It may be suggested that impairment of the criterion might be due to enhancement of motor activity, rather than to deprivation of paradoxical sleep per se.

[The role of synchronized electric activity in the development of epileptiform discharges].

The possibility of production of the epileptiform discharges throughout the sleep--wakefulness cycle was studied by means of thresholds for isolated EEG epileptiform discharges in cats. The experiments with artificially induced EEG synchronization (nembutal) indicate that the EEG synchronization does not facilitate the epileptiform discharges. However, this fact does not include the well--known standpoint concerning the preferential role of the EEG synchronization in provoking generalized seizures.

[Effect of paradoxical sleep deprivation on elaboration and differentiation of alimentary conditioned reflexes].

Paradoxical sleep deprivation of cats by means of awakening them without any significant emotional stress does not affect the acquisition of sound discrimination. Paradoxical sleep deprivation by Jouvet's method producing emotional stress impairs the acquisition of sound discrimination. However, it fails to affect the reproduction of preliminary elaborated sound discrimination.

Effect of experimentally induced generalized seizures on the wakefulness--sleep cycle.

The effect of experimentally induced generalized seizures on the relations between the various phases of sleep in the wakefulness--sleep cycle was studied in cats with chronically implanted electrodes. After generalized convulsions induced by electrical stimulation of the dorsal hippocampus, unlike those of amygdalar origin, clearly defined changes were observed in the structure of the wakefulness--sleep cycle. In the postseizure period, with increasing wakefulness sharp depression of paradoxical sleep takes place.

[Effect of experimentally induced generalized convulsions on the sleep-wakefulness cycle].

Electrical stimulation of the dorsal hippocampus appeared to have obvious effect on the ratio of phases of the wakefulness--sleep cycle: during the postconvulsive period when wakefulness is prolonged, paradoxical sleep is sharply decreased, while the slow wave sleep changes are insignificant. However, this effect is less pronounced after generalized seizures evoked by amygdaloid stimulation. Thus unspecific hyperactivation of the brain during experimentally induced generalized seizures exert an acute effect on the paradoxical sleep shortening its duration.

Effects of electrical stimulation of the mesencephalon and diencephalon on the paradoxical phase of sleep.

During paradoxical sleep electrical stimulation of the mesencephalic reticular formation and emotiogenic structures in the mesencephalon and diencephalon produced depression or an increase in the theta rhythm of the hippocampal and entorhinal electrical activity. However, stimulation not involving behavioral arousal did not cause a transition from paradoxical phase into slow wave sleep. The cessation of stimulation restored the normal structure of the paradoxical phase.

Effects of cingulate cortex lesions on emotional behavior and delayed responses in cats.

Bilateral thermocoagulation of the cingulate gyri produced an abolishment of fear reactions concomitantly with an exaggerated aggressiveness and a drastic impairment of delayed responses. The changes in emotionality subsided after several months but there was no recovery, even after prolonged post-operative training, of the dalayed responses with a 5 min delay. Only partial improvement of the responses with shorter delays (10 sec and 1 min) was observed.

Electrical activity of the hippocampus during delayed responses and hypothalamic stimulation in the cat.

Electrical activity of hippocampus was investigated in cats in the delayed response situation by comparing spectral analysis and integration of electrohippocampogram rhythms in different stages of delayed response performance. In addition, electrical stimulation of lateral and ventromedial hypothalamic nuclei was used to observe changes in the hippocampal theta rhythm, as well as the behavioral effect during the delayed response performance. It is concluded that changes in the hippocampal theta rhythm are related to the changes in the drive level: high drive results in increasing the theta rhythm, whereas drive reduction results in its suppression.