Publications by authors named "Koray Gencay"

Article Synopsis
  • The study aims to evaluate the cytotoxicity of different adhesive systems on human dental pulp cells, focusing on their adhesion, surface smoothness, and potential toxicity.
  • Using a specific cell line, researchers applied various adhesive systems and MTA, assessing cell viability through trypan blue staining over three days.
  • Results indicated a significant difference in cell viability on the first day, but similar biocompatibility between Futurabond M and MTA was observed, suggesting Futurabond M’s suitability for use in dental cavities with minimal hard tissue remaining.
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This study evaluated the influence of socio-demographic, clinical, and parental psychological factors on oral health-related quality of life (OHRQoL) and determined their predictors in preschool-aged children with traumatic dental injury (TDI). The study sample consisted of 324 dyads of children and their parents attending the Clinics of Pediatric Dentistry at Istanbul University. After clinical examination, the Sense of Coherence (SOC), Generalized Self-Efficacy Scale, Early Childhood Oral Health Impact Scale, and Multidimensional Health Locus of Control Scale-MHLC questionnaires were administered to the parents.

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Objectives:  Precocious puberty indicates quick growth inception and delayed puberty indicates retardation in growth. This study aimed to investigate whether dental development is synchronous with somatic development.

Materials And Methods:  In this study, 62 girls and 34 boys with precocious puberty aged 5 to 9, 29 girls with delayed puberty aged 13 to 16, and 43 boys with delayed puberty aged 14 to 17; 169 children (91 girls and 78 boys) with normal development were compared about their dental ages through their panoramic radiographs by using the Demirjian method and skeletal ages from hand-wrist radiographs by using Greulich-Pyle atlas.

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Article Synopsis
  • Recent studies explored the genetic factors influencing dental caries by analyzing the oral microbiota in monozygotic (MZ) and dizygotic (DZ) twins.
  • DNA samples from saliva of 198 patients, mostly children, were collected and analyzed to study the composition of their oral bacteria.
  • The findings revealed that MZ twins have more shared bacterial content compared to DZ twins, providing a substantial dataset for future research on children's oral microbiomes and dental health.
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The aim of this article was to review the literature and present a case of regional odontodysplasia (ROD) with special emphasis on clinical and radiographic features. A 6-year-old girl was referred to our department with the chief complaint of missing her permanent maxillary left central incisor, lateral incisor, and both of her canines. The gingiva of the involved region was enlarged, fibrous, and tense.

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Objective: The goal of the present work was to use dental conditions that have been independently associated with cleft lip and palate (CL/P) as a tool to identify a broader collection of individuals to be used for gene identification that lead to clefts.

Study Design: We studied 1573 DNA samples combining individuals that were born with CL/P or had tooth agenesis, supernumerary teeth, molar incisor hypomineralization, or dental caries with the goal to identify genetic associations. We tested 2 single-nucleotide polymorphisms that were located in the vicinity of regions suggested to contribute to supernumerary teeth.

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Background/aims: Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether AI patients with known -FAM20A mutations also have nephrocalcinosis.

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Article Synopsis
  • Amelogenesis imperfecta is a rare genetic disorder affecting tooth enamel, and this study aimed to identify the genetic causes in two families with hypomaturation form of the condition.
  • DNA from family members was analyzed using whole exome sequencing, leading to the discovery of specific mutations in both families.
  • The findings highlight the genetic diversity in amelogenesis imperfecta and provide insights into how different mutations can influence the observed clinical traits.
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Amelogenesis imperfecta (AI) is a heterogeneous group of genetic disorders affecting tooth enamel. The affected enamel can be hypoplastic and/or hypomineralized. In this study, we identified ACPT (testicular acid phosphatase) biallelic mutations causing non-syndromic, generalized hypoplastic autosomal-recessive amelogenesis imperfecta (AI) in individuals from six apparently unrelated Turkish families.

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Purpose: The objective of this case series was to determine the oral, dental and craniofacial features of patients with EvC syndrome.

Material And Methods: Eight patients with EvC syndrome were enrolled. A complete family history, pedigree analysis, detailed medical history were collected.

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Background: Talon cusp is a rare dental anomaly characterized by a cusp-like projection, often including the palatal surface of the affected tooth. The aim of the present study was to investigate the prevalence and characteristics of talon cusps in a group of Turkish children.

Materials And Methods: The study population consisted of 14,400 subjects who attended the clinics of the Department of Pediatric Dentistry at the Istanbul University, Istanbul, Turkey.

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Truncation mutations in FAM83H (family with sequence similarity 83, member H) cause autosomal dominant hypocalcified amelogenesis imperfecta (ADHCAI), but little is known about FAM83H function and the pathogenesis of ADHCAI. We recruited three ADHCAI families and identified two novel (p.Gln457*; p.

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The principles of management of mandibular fractures differ in children when compared to adults and depend on the specific age-related status of the growing mandible and the developing dentition. This paper presents a case report with a complex facial trauma affecting the mandibular body and condyle region and dentoalveolar complex. Clinical examination revealed soft tissue injuries, limited mouth opening, lateral deviation of the mandible, an avulsed incisor, a subluxated incisor, and a fractured crown.

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Objective: The aim of this in vitro study was to evaluate antimicrobial activities of three different pulp capping materials; Biodentine, mineral trioxide aggregate (MTA) Angelus, and Dycal against Enterococcus faecalis and their durability with time.

Materials And Methods: Direct contact test was used for the assessment. Three sets of sealers were mixed and placed on microtiter plate wells: One set was used within 20 min of recommended setting time while others were used after 24-h and 1-week.

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The aim of this clinical case series is to present a diagnosis and different treatment methods of patients in different ages with amelogenesis imperfecta (AI) as well as further treatments during a 3-6 years follow-up period. A number of 31 patients (16 female, 15 male with a mean age of 10.77 ± 2.

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Background: Periodontal ligament (PDL) healing and long term prognosis of replanted avulsed teeth should rely on several factors including length of extra-oral dry time and type of the storage medium. The status of periodontal ligament is critical for the healing of replanted teeth. Different substances have been used for root surface treatment to promote formation of PDL and increase the survival of avulsed teeth submitted to replantation.

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Aims: The purpose of this study was to investigate the relationship between vertical asymmetries of the mandibular condyle with different occlusion types, including Angle Cl I, Cl II, Cl III malocclusions and unilateral posterior crossbite (UPC) in adolescent patients.

Methodology: A total number of 120 patients (60 girls, 60 boys with a mean age of 13.64 ± 1.

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Aim: Some of the commonly encountered dental emergencies are traumatic dental injuries. The aim of this study was to evaluate traumatic dental injuries with regard to age, gender, etiology, classification of trauma, teeth involved, place of injury, and treatment received by patients who were referred over a 2-year period to the Istanbul University, Faculty of Dentistry, Clinics of Pedodontics, Istanbul, Turkey.

Materials And Methods: The study was based on the clinical data of 154 patients (337 traumatized teeth).

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Dentigerous cysts (DCs) are benign odontogenic cysts that are associated with the crowns of permanent teeth. The purpose of this study is to describe the management of DCs in four children. Four boys aged between 7 and 9 years were referred to our clinics with the complaints of intraoral alveolar swelling or facial asymmetry on the affected area.

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Aim: The aim of this study was to quantify and compare the amount of methyl methacrylate (MMA) monomer released from three different denture base acrylic material processed by different polymerization methods and storage conditions.

Materials And Methods: Microwave-cured, conventional heat and injection-technique acrylic polymerized materials were stored in neutral (pH = 7) and acidic (pH = 4.5) artificial saliva for 24 hours at the room temperature, separately.

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Genetic disturbances during dental development influence variation of number and shape of the dentition. In this study, we tested if genetic variation in enamel formation genes is associated with molar-incisor hypomineralization (MIH), also taking into consideration caries experience. DNA samples from 163 cases with MIH and 82 unaffected controls from Turkey, and 71 cases with MIH and 89 unaffected controls from Brazil were studied.

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Objective: To describe the clinical and radiological features of children with inverted supernumerary teeth.

Study Design: Thirty eight patients with inverted supernumerary teeth (ST) were enrolled in this descriptive and restrospective study. Data from patient records including age, gender, status of dentition, number of ST, number of ST in inverted position, coexistence of ST in inverted and normal direction of eruption, location, orientation, morphology, clinical complications, management and radiography were assessed during 3-years period.

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Article Synopsis
  • Iatrogenic trauma refers to injuries or adverse conditions in patients that result from medical or dental treatments, specifically focusing on orthodontics.
  • The article discusses oral tissue lesions caused by orthodontic procedures and outlines the management of these injuries based on severity, highlighting the importance of effective treatment to prevent long-term damage.
  • Dentists must be knowledgeable about these risks to inform patients properly and help them make educated decisions regarding their orthodontic treatment.
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Article Synopsis
  • Langerhans cell histiocytosis (LCH) is a rare condition characterized by the abnormal proliferation of Langerhans cells, often seen as a bone lesion, especially in children.
  • A case study of a 2-year-old boy demonstrated symptoms like fever, bleeding gums, and a rash, along with severe bone loss around his teeth, prompting a gingival biopsy.
  • Although the exact cause of LCH is unknown, it may be linked to environmental factors and viruses like Epstein-Barr, and oral symptoms might be the first signs of the disease.
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Objective: Kabuki syndrome is a rare autosomal dominant trait with variable clinical expression. Common dental manifestations of Kabuki syndrome are high-arched palate, micrognathia, malocclusion, microdontia, small dental arches, hypodontia, severe maxillary recession and mid-facial hypoplasia.

Study Design: This report includes the oral manifestations of a Turkish patient with Kabuki syndrome with consideration of the long-term craniofacial prognosis for this patient based on the physical, clinical and radiological findings in 9 years follow-up period.

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