Prospects for Use of Botulinum Toxin Type A for Prevention of Hypertrophic and Keloid Scars after Surgeries.

 To evaluate the possibility of improving and preventing the formation of postoperative hypertrophic and keloid scars using botulinum toxin type A (BTA).  Scientific articles published in English have been systematically screened in PubMed/MEDLINE database over the entire period. The following information about the studies was analyzed: first author surname; year of publication; number of patients; average age; scar location; dosage of the drug administered; follow-up duration; scar assessment methods; results, incidence of hypertrophic and keloid scars formation.

Circumlateral Vertical Augmentation Mastopexy for the Correction of Ptosis and Hypoplasia of the Lower Medial Quadrant in Tuberous Breast Deformity.

Background: Type I tuberous breast deformity (according to Grolleau's classification) is characterized by the hypoplasia of the lower medial quadrant of the mammary gland and ptosis of the lower lateral quadrant. This results in an aesthetic imbalance in the breast that has an unnatural and unattractive appearance. The study aims to propose a surgical technique ensuring the successful correction of hypoplasia of the lower medial gland quadrant combined with ptosis.

Tuberous Breast Deformity Correction: 12-year Experience.

Background: This article shows our 12-year experience in application of the technique of breast parenchyma modification with simultaneous augmentation on the tuberous breast. We undertook the study, and with the results of this study we can say that tuberous breast deformation is a common pathology that is caused not only by a thickening of the superficial fascia but also by breast parenchyma fibrosis. When traditional techniques without parenchyma modification are used during the surgery, it is often that patients come back to treat complications.

[Changes in body composition of oncological patients receiving nutritional support].

Unlabelled: The article is devoted to problems of diagnostic and correction of malnutrition at patients with gastric cancer, undergoing the gastroectomy.

Aims: to study losses of body mass and dynamics of boby composition in organism of patients with gastric cancer, undergoing surgery, to estimate the efficiency of nutritional support.

Materials And Methods: open prospective cohort case-control study.

[Effect of melafen on mitochondrial apparatus of apical meristem in growth regulation in potato tubers].

Growth stimulation in potato Solanum tuberosum L. tubers by melafen preparation caused an increase in area ofmitochondrial apparatus (increase in mitochondrial size) in apical meristem cells. Melafen stimulated mitochondrial differentiation (increase in number of condensed mitochondria enriched in cristas).

[Effect of salicylic acid on the proton translocation activity of plasmalemma of potato tuber cells].

Action of salicylic acid (SA) on the activity of membrane bound H(+)-ATPase and passive proton permeability of plasmalemma membrane vesicles (PMV) from parenchyma cells of potato tubers was detected. A correlation between SA action and germination of tubers and activity of plasmalemma H(+)-ATPase was revealed: the application of growth-stimulating concentrations of SA (10(-10)-10(-8) M) in the system in vitro resulted in activation of plasmalemma H(+)-ATPase, while the utilization of growth-inhibiting concentrations (10(-4), 10(-5) M) provoked inhibition of the enzyme activity. Addition of jasmonic acid (JA) to the incubation mix resulted in increase of SA effect on the accumulation of H+ in PMV.

[Influence of a moist-heat treatment on protein fractions of wheat].

Influence of different temperature modes of a moist-heat treatment on the protein fractions of wheat, grown in Uzbekistan, has been studied within a temperature range from 40 to 80 degrees C. Using inversed phase and exclusion chromatography, we have revealed that moist-heat treatment reduces the extract content and causes some changes in the ratio between high- and low-molecular components. If the treatment temperature exceeded 60 degrees C, then, in all cases, except the glutenin fraction, the content of high-molecular components decreased, whereas the content of low-molecular components increased.

[The effect of physiologically active compounds on the production of ethylene and the activity of polygalacturonase inhibiting protein in fruits].

The treatment of apple and banana fruits with 2-CEFA and ethacyde induced the production of ethylene and accelerated the ripening and accumulation of ACC in apple fruits. Inhibitors AOA, AVG, and CoCl2 acted at the different steps of ethylene biosynthesis, inhibited the physiological aging process and increased storage longevity. Treatment with astaxantine and BOA delayed the pick of ethylene production by fruits.

[Melafen effect on ATP-dependent accumulation of calcium in plasma membrane vesicles from cells of potato tubers].

Synthetic growth regulator melafen (10(-5)-10(-10) M) was tested for an effect on the Ca2+ accumulation in plasma membrane vesicles (PMVs) isolated from potato Solanum tuberosum L. tubers at forced rest and sprouting. Melafen proved to regulate the Ca2+ accumulation in PMVs by changing the activity of Ca2+, Mg(2+)-ATPase of the plasma membrane, while no effect was observed with respect to Ca2+ outflow from vesicles.

[Changes in the plastid apparatus of apical meristem cells of potato tubers upon growth regulation with jasmonic acid].

A comparative ultramorphometric study of the effect of jasmonic acid (JA) on the plastid apparatus in apical cells of potato tubers varying in physiological state was performed. When tubers were treated with JA at forced rest, the plastid apparatus of apical cells decreased in area and plastid proliferation was suppressed. When treatment was performed during growth, the area of the plastid apparatus remained unchanged, division was suppressed, and plastid budding was stimulated in apical cells.

Complex secondary prophylactics of degenerative joint diseases.

Positive effects of complex therapy of osteoarthrosis with alflutop and artrofoon compared to standard therapy are noted.

[Interference of phytohormones and synthetic growth regulator melafen in the control of Ca2+ translocation across the plasma membrane of potato (Solanum tuberosum L) tuber cells].

Interference of phytohormones (jasmonic, gibberellic, and abscisic acids) and synthetic growth regulator melafen on Ca2+ translocation across the membrane of plasma membrane vesicles prepared from dormant potato (Solanum tuberosum L.) tubers was studied. The activity of plasma membrane Ca2+, Mg(2+)-ATPase was stimulated by melafen and jasmonic and gibberellic acids and suppressed by abscisic acid.

[Blood-saving technologies: algorithm of operation blood loss compensation in planned surgical procedures].

The investigation was performed in 539 patients operated upon for diseases of organs of the chest, abdomen and lower extremity arteries in order to improve the methods of blood loss compensation and to develop optimal programs of saving blood in planned surgical procedures. An algorithm of compensation of perioperative blood loss has been developed allowing considerable improvement of the results of treatment of patients with severe surgical pathology requiring planned operations of large volume. The results of the investigation suggest that it is possible to use autohemotransfusions as effective and safe methods of compensation and therapy of acute perioperative blood loss.

[The effect of ethylene biosynthesis regulators on metabolic processes in the banana fruits in various physiological states].

The effects of ethylene-evolving preparations-2-chloroethylphosphonic acid (2-CEPA), the new generation binary preparation ethacide, and the specific inhibitor of ethylene biosynthesis aminooxyacetic acid (AOA)--on the ethylene evolution by banana (Musa sp.) fruits at various ripening stages and the content of protein inhibitor of polygalacturonase (PIPG), associated with prevention of fruit tissue softening, were studied. It was demonstrated that the ripening stage was of significant importance for the results of treatment with the mentioned preparations.

[Effect of jasmonic acid on Ca+2 transport through the plasmalemma of potato tuber cells].

The rate of Ca2+ accumulation in plasmalemma vesicles isolated from quiescent and sprouting potato (Solanum tuberosum L.) tubers and the effect of 10(-5) - 10(-10) M jasmonic acid on the accumulation of Ca+2 in plasmalemma vesicles and its efflux were studied. It was found that potato tuber plasmalemma contains a Ca+2, Mg+2-ATPase whose activity decreases upon the transition from forced quiescence to growth.

Polygalacturonase-inhibiting protein is a structural component of plant cell wall.

It is generally believed that plants "evolved a strategy of defending themselves from a phytopathogen attack" during evolution. This metaphor is used frequently, but it does not facilitate understanding of the mechanisms providing plant resistance to the invasion of foreign organisms and to other unfavorable external factors, as well as the role of these mechanisms in plant growth and development. Information on processes involving one of the plant resistance factors--polygalacturonase-inhibiting protein (PGIP)--is considered in this review.

[Effect of melafen on the function of endoplasmic reticulum and plasmalemmal H+ -ATPase in the regulation of growth processes in potato tubers].

The mechanism of the stimulatory effect of melafen on potato tuber sprouting was studied. The treatment with 10(-8) M melafen intensified division and stretching and activated granular endoplasmic reticulum of apical meristem cells. An increase in the activity of membrane-bound H+-ATPase in the plasmalemma of parenchymal cells of melafen-treated potato tubers and enhancement of passive proton permeability of the plasmalemma was observed.

[Compensation of operation blood loss by autohemotransfusion with intraoperative blood taking or infusion of colloid and crystalloid solutions].

Compensation of operation blood loss up to 10% of the circulating blood volume (CBV) by autohemotransfusion with intraoperative blood collection (33 patients) and infusion of colloid and crystalloid solutions (33 patients) was studied. It was shown that the intraoperative blood loss up to 10% of CBV resulted in statistically considerable changes in hemoglobin, packed cell volume, erythrocytes, and fibrinogen appearing by the moment of blood loss compensation; within 4-6 hours after surgery the changed clinical and hemostasiological indices caused by blood loss up to 10% of CBV were rapidly arrested by autohemotransfusion with the intraoperatively collected blood or infusion of colloid and crystalloid solutions. No advantages of autohemotransfusion with the intraoperatively collected blood over the infusion of colloid and crystalloid solutions were found in compensation of intraoperative blood loss up to 10% of CBV.

[The effect of melamine salt of bis(oxymethyl)phosphinic acid (melafen) on the growth processes and cytoplasmic membrane function in potato tuber cells].

The effects of a new synthetic growth regulator, preparation melafen, on the growth processes in potato plant tubers and the H+ -ATPase activity in cell plasmalemma were studied. It was demonstrated that melafen could both stimulate and inhibit the growth of potato tubers depending on its concentration and the physiological state of the tubers. It is likely that one of the manifestations of melafen action is its influence on the division and extension of apical meristem cells.

[State of free radical processes, metabolism of nitrogen oxide, iron and cortisol level in autohemotransfusion and transfusion of the donor blood].

Under study were the main regularities of changes in processes of peroxidation and antioxidant defense in patients with different methods of operative hemorrhage replacement. Autohemotransfusion was fulfilled in 33 patients; donor blood was transfused to 33 patients. It was concluded that donor blood transfusion gave rise to activation of lipid peroxidation processes and decrease of antiradical activity.

[The effect of thaumatin gene overexpression on the properties of H(+)-ATPase from the plasmalemma of potato tuber cells].

The introduction of the thaumatin gene into potato plants was accompanied by a decrease in the activity of H(+)-ATPase in the plasmalemma (PL) of tuber cells. When tubers were released from dormancy, the enzyme was activated in the tuber cells of both the original and transgenic plants. Experiments performed in vitro demonstrated that sensitivities to ambiol (AM) and jasmonic acid (JA) of H(+)-ATPase in the PL of tubers from the original plants were lower after the release from a period of deep dormancy.

[Ultramorphometric study of the plastids in apical tuber cells of original and transgenic potato plants treated with ambiol].

Ultramorphometric characteristics of plastids in cells of apical tuber meristems of original and defensin gene-transfected potato (Solanum tuberosum L.) plants, either maintained under normal conditions or subjected to treatment with the antioxidant ambiol, were compared. Under normal conditions, the tuber cells of the original and transgenic potato plants differed in neither the number nor size of the plastids.

[Effect of ambiol on the ultrastructure of mitochondria in the apical cells of tubers of original and transgenic potato plants].

The ultrastructure of the mitochondrial apparatus of apical tuber cells of original and transgenic (defensin gene-transfected) potato have been compared in normal and ambiol-treated plants, using morphometric approaches. No qualitative or quantitative differences were found between the mitochondria of original and transgenic plants under normal conditions (control). Treatment with ambiol produced only quantitative differences (in the number of mitochondria and their volume) between the cells of original and transgenic plants.

[Phytohormone interactions in the control of proton translocation activity of plant cell plasmalemma].

The effects of phytohormones (abscisic acid, gibberelic acid, and jasmonic acid) and ambiol (a synthetic growth regulator) on processes of H+ transport across the plasmalemma were studied in membrane vesicles isolated from the parenchyma of potato (Solanum tuberosum L.) tubers. Phytohormones and ambiol were tested either individually or in combinations.