α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells.

Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis. Although the engagement of the latter in survival and proliferation of rat C6 glioma has been shown, there are practically no data about the presence and the role of nAChRs in C6 cells.

Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors.

Phospholipase A (named bitanarin) possessing capability to block nicotinic acetylcholine receptors (nAChRs) was isolated earlier (Vulfius et al., 2011) from puff adder Bitis arietans venom. Further studies indicated that low molecular weight fractions of puff adder venom inhibit nAChRs as well.

[ECHOCARDIOGRAPHIC PREDICTORS OF THE SEVERITY OF THE EARLY POSTOPERATIVE PERIOD IN PATIENTS AFTER SURGICAL MYOCARDIAL REVASCULARIZATION].

Non-invasive and easily interpretable methods for assessing cardiac hemodynainic parameters including various echocardiographic technologies are highly valuable diagnostic methods in cardiac surgery patients admitting the intensive care unit in the postoperative period. The article presents echocardiographic features of the myocardial functional state in the early period after coronary artery bypass grafting performed in 201 CHD patients. The analysis includes standard echocardiographic parameters and data obtained from tissue Doppler imaging.

Echocardiographic diagnosis of a massive left ventricular pseudoaneurysm: a case report.

Left ventricular aneurysm is one of the most troublesome complications of myocardial infarction. This complication results from LV wall rupture and presents as a cavity contained by pericardium and fragments of the ruptured wall. The risk of pseudoaneurysm rupture is very high and this makes the prognosis for the disease extremely unfavorable.

Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity.

NK cells that mediate ADCC play an important role in tumor-specific immunity. We have examined factors limiting specific lysis of tumor cells by CD16.NK-92 cells induced by CNTO 95LF antibodies recognizing αV integrins that are overexpressed on many tumor cells.

Conformationally restricted nonchiral pipecolic acid analogues.

Practical syntheses of 2-azabicyclo[3.1.1]heptane-1-carboxylic (2,4-methanopipecolic), 2-azabicyclo[2.

[Membrane potential equations].

In the electrostatic approximation, the problem on the propagation of an electric signal along a thin layer that models a cell membrane has been considered. On both sides of the membrane, volume conductors with different properties are present. Different types of boundary conditions have been investigated.

[Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters].

The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis.

[Antiviral effectiveness of the combined use of amixine and virasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice].

The antiviral effectiveness of the combined and single use of superlow-dose amixine and virasole on the course of experimental hemorrhagic fever with renal syndrome was studied in sucking albino mice parenterally infected with their virus Hantaan. The co-administration of virasole and amixine was shown to protect 52% of the infected animals from death, which is superior to the effect of their monotherapy. The combined use of the drugs substantially prolongs the survival of albino mice after their infection and the level of brain viral reproduction suppression ( delta = 3.

[Epidemiology of mycoses in submariners based on the Kola Peninsula].

Subject of the study was spreading of mycoses in the troops based on the Kola Peninsula. Examined were the military serving on atomic submarines, maintenance crews of deactivated atomic submarines awaiting disposal, and coastal units. Spreading of skin lesions among the submariners was not same as among the coastal military.

[Effectiveness of virazol, realdiron and interferon inductors in experimental Omsk hemorrhagic fever].

Efficacy of drug therapy of Omsk hemorrhagic fever (OHF) was tested experimentally using cell culture and laboratory animals infected with the OHF virus strain Ondatra. Screening tests showed that high concentrations of Virazol or interferon inducers Larifan and Rifastin caused moderately pronounced suppression of virus reproduction in cell culture. Realdiron was found to be a high-efficacy preparation causing complete inhibition of virus reproduction in cell.

[Comparative study of special products "Tetraphen" and "Phenyl-free" in diet therapy of children with phenylketonuria].

Basing on the comparative clinical and biochemical evaluation of the usage of the specialized product "Tetraphen" (Russia) and early utilized product "Phenyl-Free" (USA) it has been shown that "Tetraphen" does not yield to "Phenyl-Free", while some of its parameters (energy value, carbohydrate content) even in the higher degree correspond to the physiologic requirements of this aged children suffering from phenylketonuria. Intake of this product in smaller doses completely covers their requirements for the basic food ingredients. High frequency of carotenoids insufficiency in children received both "Tetraphen" and "Phenyl-Free" demonstrate necessity of the diet correction by means of beta-carotene additional supplementation.

[Structural and functional parameters of the myocardium and atrial natriuretic peptide in atrial fibrillation].

The plasma level of atrial natriuretic factor and its relation to intracardiac and systemic hemodynamic parameters were examined in patients with coronary heart, rheumatic and mitral valvular diseases, neurocirculatory dystonia which were complicated by atrial fibrillation. The concentration of atrial natriuretic factor was found to vary with the left ventricular myocardial mass, left atrial contractility, antiarrhythmic therapy intensity and efficacy.

[Methodological approaches to a statistical analysis of the data from a population survey of children in a study of the causes of obesity].

To elaborate unified criteria for the physical development evaluation in children, a comparison was made of two populations of children in the Estonian SSR: with normal and excessive body mass (EBM). The investigation was conducted by the cohort type, the children were divided into groups according to their age, sex, residence and nationality. To study the influence of the above factors on the distribution of Quetelet's index (the basic parameters of EBM) in the population of children in the Estonian SSR, a criterion was used, characterizing variations of the populations with respect to each of the factors with due regard for the rest factors.

[Characteristics of the actual nutrition of Estonian and Finnish children].

The initial stage of the joint Soviet-Finnish scientific investigations of the risk factors of obesity in children is presented in the paper. The investigations were conducted by the Nutrition Department of the Institute of Nutrition of the Academy of Medical Sciences of the USSR, in the Estonian SSR, and the Helsinki University in Finland. The authors have analyzed daily intake of varying food products by children aged from 1 to 15 years, as well as daily average-energy consumption with food ration as a whole and separately at the expense of protein, fatty and carbohydrate components of food rations of these children.

[Blood serum proteins studied by a method of polyacrylamide gel disc electrophoresis in children with phenylketonuria].

Protein spectra of blood serum were studied in 25 children suffering from phenlyketonuria (PKU) by disc electrophoresis in polyacrylamide gel. 14 children were examined in the course of being given a specialized diet on the basis of berlafen and 11 children were examined after they were switched over to common diet. PKU patients had an increased protein content in the zone of transferrins.

[Relationship between the severity of brain damage in phenylketonuria and the degree of hyperphenylalaninemia].

The frequency of the various degrees of the intellectual defect and convulsive syndrome was studied in 473 patients with phenylketonuria divided into four groups as regards the phenylalanine blood level, that was 150 to 199 mg/l in group I, 200 to 299 mg/l in group II, 300 to 399 mg/l in group III, and 400 mg/l and higher in group IV. A substantial increase of the number of patients with grave mental derangement and epileptic seizures was noted in groups II and IV: this shows that the risk of the grave mental affection is the greater the higher the phenylalanine serum level. An increased number of patients with a slight intellectual derangement in group I (43.

[Dynamics of the humoral immunity indices in children with phenylketonuria against a background of diet therapy and after its discontinuance].

The paper concerns variations in some parameters of humoral immunity in children with phenylketonuria examined at varying time (in the presence of specific dietetics and after its discontinuation). It is concluded that in children over 5 years of age, the hyperphenylalaninemia newly occurring after discontinuation of dietetics does not exert any material effect on the function of the mature enough immune system.

[Dietary treatment of children with phenylketonuria].

The sole method of treating phenylketonuria, a grave hereditary illness, is at present dietary cure. A principle for formulating therapeutic rations in this pathology is set forth, and approximate menus for children of different age groups are presented. Exclusion from the ration of an ill children of basic proteinaceous products securing a normal growth and development of the developing organism, requires a painstaking observence of the proposed rations.

[Assessment of the adaptational potentials of the body of children with phenylketonuria to diets including berlofen in long-term diet therapy].

The state of the nitrogen balance and physical development of 14 children ill with phenylketonuria (PKU), aged from 5 1/2 to 8 years, kept on a long dietotherapy for 21/2--61/2 years and subsequent application of a broadened ration of alimentation, was studied. A lengthy dietotherapy is shown to bring about an adaptation of child's organism to restricted phenylalanine in the food, but a diet with berlophen is not optimal for the normal physical development of children suffering from PKU. In children aged over 5 a broadened diet is suggested.

[B group and ascorbic acid vitamin allowance of the therapeutic rations of phenylketonuria patients].

The allowance of the vitamin group B and ascorbic acid in specialized rations for children suffering from phenylketonuria was studied. A significant deficiency in a number of the study vitamins (thiamine, riboflavin, pyridoxine, niacin, ascorbic acid) was detected, this being confirmed by the excretary findings. Inclusion of protein-free and of products enriched with vitamins in the ration could not fully correct the diet as concerns the study vitamins.

[The activity of glutathione-reductase and FAD-effect as indicators of the riboflavin level in experiments and in patients with phenylketonuria].

Subjects of discussion in the paper are various methods of determining the riboflavin allowances and the results achieved by the application of two of them that concern determining the activity of the glutathione-reductase and the FAD-effect in the study of an experimental B2-deficiency in rats and the riboflavin allowances in children suffering from phenylketonuria. Exclusion of vitamin B2 from the ration of rats resulted in that in 8 weeks they developed B2-deficiency ascertained with the help of the above cited enzymatic tests. In a certain percentage of children with phenylketonuria after discontinued administration of group "B" vitamins (D1 diet) there could be observed an intensification of the FAD-effect and, accordingly, a reduced glutathione-reductase activity.