[Immunophenotypic characteristics of blood lymphocytes and expression of cytokine receptors in newborn infants].

Formation of the immune system during the neonatal period was studied in 88 infants aged 3 days-1 month (gestation age 28-41 weeks) with the primary diagnosis of cerebral ischemia. The patients were allocated to 4 groups based on chronological and gestational age at the moment of examination and a reference group. A total of 16 umbilical blood samples were available for analysis.

[In vitro cell adhesion and integrin expression by calcium ionophore-treated mononuclear cells from patients with acute myeloid leukemia].

As shown elsewhere, cultured acute myeloid leukaemia blasts acquire certain characteristics of dendritic cells upon stimulation with cytokines and calcium ionophore. The ability of leukaemia-derived dendritic-like cells to express immune costimulatory molecules and dendritic cell marker CD83 has been extensively investigated. Although migratory capacity is a major attribute of dendritic cells, the ability of in vitro modified blasts for adhesion, chemotaxis and homing remain elusive.

[Hematopoietic cells of fetal liver. 1. Effect of growth factors of varying origin and activity of granulocyte-macrophage progenitor cells].

The liver is the leading hemopoietic organ of 5-22-week embryo and fetus. Hepatic hemopoiesis activity is assessed by concentration, total count and proliferative capacity of granulomonocytic cell precursors (GMCP). Cloning efficacy (GMCP CE) in the liver of 7 fetuses of 16-22 weeks of gestation was evaluated in vitro.

[Expression of glucocorticoid receptors and blast cell clearance in children with different variants of acute lymphoblastic leukemia].

Glucocorticoid receptor (GR) levels were estimated in blast cells of 24 children with acute lymphoblastic leukemia, in different immunocytologic subvariants of the disease. No relationship was revealed between immunophenotype and GR number in blasts. It was found that the response to prednisolone therapy did not depend on the number of sites specifically bound to glucocorticoids.