[The role of gastric pH and tissue hypoxia in formation of gastroduodenal zone mucose changes in heartsurgical patients].

The estimation of gastric contents pH and gastroduodenal zone mucous membrane condition based on the fibrogastroduodenoscopy data of40 patients who were examined and received proton pump inhibitors in the postoperative period after heart surgical intervention. It was estimated, that acidic peptic aggression and tissue hypoxia are important factors for occurrence of destructive gastroduodenal membrane changes in heart surgery patients. The differences of antisecretory activity of proton pump inhibitors are revealed, so it was useful to use analogous pH-test using in the intensive care unit.

[Stress-dependent lesions of the gastroduodenal mucosa during operations with cardiopulmonary bypass].

A continuous retrospective study was conducted in order to reveal risk factors and optimal ways of prophylaxis of gastroduodenal hemorrhage after operations with cardiopulmonary bypass. All the 559 cases operated on with cardiopulmonary bypass in Department of Cardiosurgery of Omsk Regional Clinical Hospital between January 2003 and December 2005 were analyzed. Risk factors and the effectiveness of different methods of antisecretory prophylaxis of hemorrhage were evaluated.

[Peptic ulcers of the gastroduodenal zone in patients with scheduled cardiac operation: continuum of heterogeneous pathogenetic effects].

The article is a review of different pathogenetic mechanisms (infectious, NSAID-associated, stress-dependent and those stipulated by microcirculation disturbances in the gastroduodenal zone) of stomach and duodenum ulcers in patients with scheduled surgical intervention on the heart with the use of cardiopulmonary bypass. Some vexed questions related to treatment tactics of peptic ulcers in these patients are discussed.

[Visceral hypersensitivity of the large intestine mucosa in patients with irritable bowel syndrome--cause of the non-inflammatory changes in the pain syndrome].

The purpose of our research was to reveal the existence of an association between clinical expressions of visceral hypersensitivity--the intensity of abdominal pain and nature of endoscopic changes in the large intestine in patients with the irritable bowel syndrome (IBS). It was established that there was a direct association between the intensity of the pain syndrome and existence of endoscopic changes in the large intestine mucous coat. The macroscopic picture regarded as an inflammation of the mucous coat in patients with the IBS is not confirmed with the data of morphological research.