Publications by authors named "Koos Plomp"
Article Synopsis
- In out-of-hospital cardiac arrest (OHCA) cases without ST-elevation, researchers investigated the usefulness of troponin-T (cTnT) levels in predicting the risk of acute coronary syndrome and patient survival.
- The study analyzed data from 352 patients, revealing that higher cTnT values were independent predictors for 90-day mortality and the presence of acute unstable lesions and thrombotic occlusions.
- However, cTnT levels did not show a significant correlation with left ventricular function, highlighting its role primarily in assessing mortality risk and acute coronary issues in these patients.
Article Synopsis
- The study aimed to evaluate the prognostic value of ischaemic ECG patterns, specifically ST-depression and T-wave inversion, in patients who experienced out-of-hospital cardiac arrest.
- Analysis of data from 510 patients revealed that 66.7% had ischaemic ECG patterns, which were linked to a significantly lower 90-day survival rate compared to those without such patterns.
- While ischaemic ECG patterns correlated with worse survival and poorer heart function, these associations disappeared after adjusting for age and time to restore blood circulation.
Article Synopsis
- A study comparing immediate versus delayed coronary angiography in patients with out-of-hospital cardiac arrest showed no significant difference in overall mean costs between the two strategies during the initial hospital stay.
- Although immediate angiography resulted in higher procedural costs, expenses related to intensive care and ward stays were similar in both groups.
- The findings suggest that a delayed approach, allowing for neurological recovery before invasive procedures, may be a more cost-effective strategy.
Objectives: The optimal targeted temperature in patients with shockable rhythm is unclear, and current guidelines recommend targeted temperature management with a correspondingly wide range between 32°C and 36°C. Our aim was to study survival and neurologic outcome associated with targeted temperature management strategy in postarrest patients with initial shockable rhythm.
Design: Observational substudy of the Coronary Angiography after Cardiac Arrest without ST-segment Elevation trial.
Article Synopsis
- A study was conducted on 552 patients who were resuscitated after cardiac arrest without STEMI, comparing immediate versus delayed coronary angiography and its impact on heart function.
- Results showed no significant improvement in left ventricular function, with ejection fractions of 45.2% and 48.4% for immediate and delayed groups, respectively.
- The conclusion indicates that immediate coronary angiography does not enhance heart dimensions or function compared to delaying the procedure after neurological recovery.
Sex differences in out-of-hospital cardiac arrest (OHCA) patients are increasingly recognized. Although it has been found that post-resuscitated women are less likely to have significant coronary artery disease (CAD) than men, data on follow-up in these patients are limited. Data for this data in brief article was obtained as a part of the randomized controlled Coronary Angiography after Cardiac Arrest without ST-segment elevation (COACT) trial.
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- The study investigates whether sex influences survival rates in patients who experience out-of-hospital cardiac arrest (OHCA) without ST-segment elevation myocardial infarction (STEMI).
- Overall one-year survival rates were similar for men (63.4%) and women (59.6%), with no significant sex differences found.
- Women had a lower occurrence of significant coronary artery disease (CAD), but when CAD was present, their survival was worse compared to women without CAD, while men did not show this discrepancy; immediate coronary angiography did not improve survival for either sex.
Article Synopsis
- Ischemic heart disease often leads to cardiac arrest, and this study aims to assess how immediate coronary angiography affects long-term clinical outcomes in patients resuscitated from cardiac arrest without STEMI.
- The research involves a multicenter clinical trial with 552 patients from Dutch centers, comparing immediate versus delayed angiography strategies, with follow-up after one year.
- Results indicate no significant difference in survival rates or adverse events between the immediate and delayed angiography groups, suggesting that the timing of the procedure may not impact outcomes significantly.
Article Synopsis
- - The study aimed to compare the effects of delayed versus immediate invasive treatment on heart damage and patient outcomes in individuals with transient ST-segment elevation myocardial infarction (STEMI).
- - Researchers randomly assigned 142 patients to receive either delayed (22.7 hours) or immediate (0.4 hours) cardiac intervention and evaluated heart function and infarct size using imaging techniques at 4-day and 4-month follow-ups.
- - Results showed no significant differences in heart damage, function, or major health events between the two treatment groups, indicating that timing of intervention may not impact outcomes in transient STEMI cases.
Article Synopsis
- * In a multicenter trial, 552 patients without STEMI were randomly assigned to receive immediate or delayed coronary angiography, with survival rates at 90 days as the primary focus.
- * Results showed no significant difference in survival rates between the immediate angiography (64.5% alive) and delayed angiography (67.2% alive) groups after 90 days, suggesting that immediate intervention may not offer a survival advantage in these cases.
Article Synopsis
- - The study focuses on patients with transient ST-segment elevation myocardial infarction (STEMI), who initially show ST-elevation on ECG but then experience symptom relief before treatment; the goal is to assess whether immediate or delayed invasive treatment is better for these cases.
- - In a trial involving 142 patients, researchers compared immediate and delayed treatment strategies and found little difference in infarct size and short-term adverse events like death or reinfarction between the two groups.
- - Conclusions indicate that the infarct size remains small regardless of treatment timing, and both immediate and delayed strategies result in similar rates of major adverse cardiac events within 30 days.
We aimed to evaluate how the presence and severity of congenital heart disease (CHD) influence social life and lifestyle in adult patients. A random sample (n = 1,496) from the CONgenital CORvitia (n = 11,047), the Dutch national registry of adult patients with CHD, completed a questionnaire on educational attainment, employment and marital statuses, and lifestyle (response 76%). The Utrecht Health Project provided a large reference group (n = 6,810) of unaffected subjects.
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