Publications by authors named "Koobmeej Lee"
Pharmacotherapy
March 2021
Article Synopsis
- Warfarin dosage is influenced by genetic factors, particularly in the Hmong population, which has been underrepresented in genetic research despite their distinct allele frequencies related to warfarin metabolism.
- The study aims to validate these allele frequency differences in Hmong compared to East Asians and to analyze predicted warfarin sensitivity and maintenance doses.
- Results show significant differences in allele frequencies for warfarin-related genes and indicate that Hmong individuals are more likely to be very sensitive to warfarin, requiring lower maintenance doses than their East Asian counterparts.*
Pharmacotherapy
February 2020
Article Synopsis
- The study aimed to explore how genetic differences in very important pharmacogenes (VIPs) among Hmong individuals could impact medication choices and dosages, comparing them with East Asians.
- 194 Hmong adults' DNA was analyzed for 22 genetic variants in 8 VIPs, with significant allele frequency differences identified in 23% of the tested variants.
- These genetic variations are likely to result in tailored medication recommendations for the Hmong population that differ from those suggested for East Asians, particularly for drugs like warfarin, simvastatin, and phenytoin.
