Publications by authors named "Koo E"
Purpose: To identify areas of consensus among experts on the performance of endothelial keratoplasty by using a modified Delphi approach, to help create a framework for novice surgeons to adopt these procedures.
Methods: Thirty-one international experts in endothelial keratoplasty participated. Two rounds of electronic survey were followed by a hybrid, virtual meeting.
Article Synopsis
- The study investigates whether using postoperative topical antibiotics reduces the risk of surgical site infections in strabismus surgery.
- The research analyzed data from over 84,000 patients, comparing those who received antibiotics with those who did not, finding no significant difference in infection rates (endophthalmitis, orbital, and preseptal cellulitis).
- The conclusion suggests that prescribing these antibiotics may be unnecessary, as they did not improve outcomes and raised concerns about costs and antibiotic resistance.
A 23-year-old woman was referred for low visual acuity in the left eye after a corneal ulcer associated with contact lens use 2 years previously. The patient had a history of contact lens use, reported use of antibiotic eye drops with improvement of infection, and subsequent scarring. There were no comorbidities.
View Article and Find Full Text PDFObjective: Evaluate the risk of age-related macular degeneration (AMD) development and progression in individuals with diagnosed obstructive sleep apnea (OSA).
Design: Retrospective cohort study.
Subjects: 60,652 and 1,173,723 individuals with OSA or not, respectively, were included in the study before propensity score matching (PSM).
Purpose: The purpose of our paper is to report on the endothelial viability of a preloaded Descemet membrane endothelial keratoplasty (DMEK) graft that was found to be in a fully opened, nonscrolled configuration in the glass cannula.
Methods: Case Report.
Results: The preloaded DMEK graft was found to be in an opened, nonscrolled configuration with the endothelial side facing outward in the micro Weiss glass cannula when the preloaded system was visualized in the operating room.
Background & Aims: Guidelines recommend that sub-centimeter nodules on ultrasound be followed with short-interval surveillance ultrasound, given assumed low risk of hepatocellular carcinoma (HCC) and suboptimal diagnostic imaging performance in lesions <1 cm. We performed a systematic review to estimate HCC risk among patients with cirrhosis and sub-centimeter nodules detected on ultrasound.
Methods: We systematically searched Ovid MEDLINE and EMBASE databases for relevant articles published between January 2005 and July 2024.
Importance: Curcuma-based nutritional supplements (CBNS) are natural anti-inflammatory and antioxidant agents that may confer benefits against age-related macular degeneration (AMD).
Objective: To examine the association between the use of CBNS and the risk of development or progression of AMD.
Design, Setting, And Participants: This was a retrospective cohort study with data collection in June of 2024.
Purpose: Patients with Crohn's disease (CD) and subsequent ocular manifestations may have worse outcomes when compared to matched patients with CD without ocular disease.
Methods: In this retrospective cohort study, an aggregated electronic health records research network, TriNetX (Cambridge, MA, USA), was used to identify patients diagnosed with CD stratified by the presence or absence of ocular involvement with at least 1 year of follow-up. Propensity score matching (PSM) was performed to control for baseline demographics and medical comorbidities.
Article Synopsis
- The study compares the effectiveness of two surgical approaches—Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping only (DSO)—for treating Fuchs endothelial corneal dystrophy (FECD) in a clinical trial called DETECT II.
- A total of 60 patients will be randomly assigned to receive either DMEK with a placebo or DSO with a drug called ripasudil, and the main goal is to evaluate visual improvement after 12 months.
- The trial aims not only to assess visual outcomes but also to explore other factors like cost-effectiveness and the incidence of adverse events, with findings planned for dissemination in scientific publications and conferences.
Purpose: Assessing immune-related ocular toxicities from immune checkpoint inhibitors (ICIs) is crucial, though rare. This study, utilizing real-world data, examines the occurrence of ophthalmic immune-related adverse events (irAEs) after ICI treatment and their impact on overall survival.
Design: A retrospective cohort study.
Importance: While combined treatment of anti-vascular endothelial growth factor (VEGF) injections plus panretinal photocoagulation (PRP) is a common approach for treating proliferative diabetic retinopathy (PDR) in the clinical practice setting, large randomized clinical trials typically use monotherapy. Subsequently, information is limited as to whether the order of treatment when combining PRP and anti-VEGF injections for PDR affects outcomes.
Objective: To compare outcomes of patients with PDR treated with PRP and subsequent anti-VEGF injections with outcomes of matched patients treated with anti-VEGF injections and subsequent PRP.
Purpose: Conversion to neovascular disease in patients with non-neovascular age-related macular degeneration (AMD) initiated on direct oral anticoagulants (DOACs) compared with matched patients treated with warfarin.
Design: Retrospective cohort study.
Participants: The study included 20 300 patients and 13 387 patients with non-neovascular AMD initiated on DOACs or warfarin, respectively, before propensity score matching (PSM).
Purpose: To evaluate the risk of diabetic retinopathy progression and systemic vascular events, including death, in patients with nonproliferative diabetic retinopathy (NPDR) with obstructive sleep apnea (OSA).
Design: Retrospective cohort study.
Methods: Electronic chart query using TriNetX, an electronic health records network comprising data from over 124 million patients.
Purpose: We aim to present a case of disseminated fusariosis that occurred in the setting of immunosuppression and presented with bilateral endogenous endophthalmitis, along with a literature review of endophthalmitis, highlighting management strategies.
Observation: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints.
KCNQ4 is a voltage-gated K channel was reported to distribute over the basolateral surface of type 1 vestibular hair cell and/or inner surface of calyx and heminode of the vestibular nerve connected to the type 1 vestibular hair cells of the inner ear. However, the precise localization of KCNQ4 is still controversial and little is known about the vestibular phenotypes caused by KCNQ4 dysfunction or the specific role of KCNQ4 in the vestibular organs. To investigate the role of KCNQ4 in the vestibular organ, 6-g hypergravity stimulation for 24 h, which represents excessive mechanical stimulation of the sensory epithelium, was applied to p.
View Article and Find Full Text PDFMitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy with defects in the brain, kidney, and eye.
View Article and Find Full Text PDFImportance: The Diabetic Retinopathy Clinical Research Network Protocol S suggested that vitrectomy for vitreous hemorrhage (VH) or tractional retinal detachment (TRD) was more common among eyes assigned initially to panretinal photocoagulation (PRP) vs anti-vascular endothelial growth factor (anti-VEGF) for proliferative diabetic retinopathy (PDR). These clinical implications warrant further evaluation in the clinical practice setting.
Objective: To explore outcomes of PDR treated with PRP monotherapy compared with matched patients treated with anti-VEGF monotherapy.
Background: Emerging diagnostic modalities suggest that miRNA profiles within extracellular vesicles (EVs) isolated from peripheral blood specimens may provide a non-invasive diagnostic alternative for dementia and neurodegenerative disorders. Given that EVs confer a protective environment against miRNA enzymatic degradation, the miRNAs enriched in the EV fraction of blood samples could serve as more stable and clinically relevant biomarkers compared to those obtained from serum.
Objective: To compare miRNAs isolated from EVs versus serum in blood taken from Alzheimer's disease (AD) dementia patients and control cohorts.
Purpose: To examine the effects of glucagon-like peptide-1 receptor (GLP-1) agonists compared to SGLT-2 inhibitors on diabetic retinopathy.
Design: Retrospective clinical cohort study using TriNetX, a federated electronic health records network comprising multiple healthcare organizations.
Methods: Patients with an International Classification of Diseases, Tenth Revision (ICD-10) code of nonproliferative diabetic retinopathy (PDR) and monotherapy treatment, excluding insulin, with GLP-1 agonists or SGLT-2 inhibitors.
Purpose Of Review: Currently, there is heightened interest surrounding endothelial cell therapy for the treatment of corneal edema. The purpose of this review article is to describe and summarize the background information as well as the research surrounding the emerging treatment modalities for endothelial cell therapy.
Recent Findings: Marked advancements have been made in the translational research in this area, and increasing refinements have been demonstrated in the treatment protocols for cell therapy.
Purpose: We herein present Descemet membrane endothelial keratoplasty (DMEK) as an effective surgical means of treatment for the management of interface fluid syndrome (IFS) in a series of cases with distant history of laser in situ keratomileusis (LASIK).
Methods: Three cases from a single institution were included. All patients had documented IFS in the setting of history of LASIK.
Purpose: To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications.
Design: Retrospective cohort study.
Methods: The TriNetX Analytics platform, a federated health research network of aggregated deidentified electronic health record data of more than 119 million patients, was used to identify patients diagnosed with Marfan syndrome.