Publications by authors named "Konstantinos Tziouvas"
Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.
View Article and Find Full Text PDFCorrection: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis.
Intensive Care Med
September 2023
Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children-a systematic review and meta-analysis.
Intensive Care Med
January 2023
Purpose: Intravenous maintenance fluid therapy (IV-MFT) prescribing in acute and critically ill children is very variable among pediatric health care professionals. In order to provide up to date IV-MFT guidelines, the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) undertook a systematic review to answer the following five main questions about IV-MFT: (i) the indications for use (ii) the role of isotonic fluid (iii) the role of balanced solutions (iv) IV fluid composition (calcium, magnesium, potassium, glucose and micronutrients) and v) and the optimal amount of fluid.
Methods: A multidisciplinary expert group within ESPNIC conducted this systematic review using the Scottish Intercollegiate Guidelines Network (SIGN) grading method.
Common Genetic Variation and Age of Onset of Anorexia Nervosa.
Biol Psychiatry Glob Open Sci
October 2022
Article Synopsis
- This study explores the role of genetics in the age of onset of anorexia nervosa (AN) by analyzing data from a large genome-wide association study involving 9,335 cases and 31,981 control participants.
- Researchers found significant genetic variations linked to typical-onset AN and identified different genetic correlations for early-onset (before age 13) and typical-onset AN, indicating distinct biological influences.
- Results suggest a genetic relationship between the age at menarche and early-onset AN, implying that earlier menarche may increase the risk of developing AN at a younger age.
Article Synopsis
- Researchers analyzed data from genome-wide association studies (GWAS) to explore genetic correlations across four eating disorder types and eight substance-use-related traits, involving large sample sizes ranging from ~2400 to ~537,000 participants.
- Findings indicated positive genetic associations between anorexia nervosa and alcohol use disorder, as well as cannabis initiation, while some negative correlations were found between anorexia without binge eating and smoking behaviors, suggesting a complex relationship between these disorders influenced by genetic and possibly depressive factors.
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness, affecting 0.9-4% of women and 0.3% of men, with twin-based heritability estimates of 50-60%.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated the genetic overlap between 25 brain disorders using data from over 1.2 million individuals, finding that psychiatric disorders share more genetic risk compared to neurological disorders, which seem more distinct.
- The research identified significant relationships between these disorders and various cognitive measures, suggesting shared underlying traits.
- Simulations were conducted to understand how factors like sample size and diagnosis accuracy influence genetic correlations, emphasizing the role of common genetic variations in the risk of brain disorders.