Evidence-based Public Health Policy Models Development and Evaluation using Big Data Analytics and Web Technologies.

Introduction: According to WHO, "health policy refers to decisions, plans, and actions that are undertaken to achieve specific health care goals within a society". Although policymaking is important to be based on scientific evidence, in many countries, evidence-informed decision-making remains the exception rather than the rule.

Aim: This work presents a cloud-based Decision Support System for public health decision-making.

Modelling and Evaluation of Policies.

Introduction: NCDs (non-communicable diseases) are considered an important social issue and a financial burden to the health care systems in the EU which can be decreased if cost-effective policies are implemented, along with proactive interventions. The CrowdHEALTH project recognizes that NCD poses a burden for the healthcare sector and society and aims at focusing on NCDs' public health policies.

Aim: The aim of this paper is to present the concept of Public Health Policy (PHP), elaborate on the state-of-the-art of PHPs development, and propose a first approach to the modeling and evaluation of PHPs used in a toolkit that is going to support decision making, the Policy Development Toolkit (PDT).

Integration of high-volume molecular and imaging data for composite biomarker discovery in the study of melanoma.

In this work the effects of simple imputations are studied, regarding the integration of multimodal data originating from different patients. Two separate datasets of cutaneous melanoma are used, an image analysis (dermoscopy) dataset together with a transcriptomic one, specifically DNA microarrays. Each modality is related to a different set of patients, and four imputation methods are employed to the formation of a unified, integrative dataset.

GOrevenge: a novel generic reverse engineering method for the identification of critical molecular players, through the use of ontologies.

The ever-increasing use of ontologies in modern biological analysis and interpretation facilitates the understanding of the cellular procedures, their hierarchical organization, and their potential interactions at a system's level. Currently, the gene ontology serves as a paradigm, where through the annotation of whole genomes of certain organisms, genes subsets selected, either from high-throughput experiments or with an established pivotal role regarding the probed disease, can act as a starting point for the exploration of their underlying functional interconnections. This may also aid the elucidation of hidden regulatory mechanisms among genes.

KEGGconverter: a tool for the in-silico modelling of metabolic networks of the KEGG Pathways database.

Background: The KEGG Pathway database is a valuable collection of metabolic pathway maps. Nevertheless, the production of simulation capable metabolic networks from KEGG Pathway data is a challenging complicated work, regardless the already developed tools for this scope. Originally used for illustration purposes, KEGG Pathways through KGML (KEGG Markup Language) files, can provide complete reaction sets and introduce species versioning, which offers advantages for the scope of cellular metabolism simulation modelling.