Publications by authors named "Konstantinos Lekkos"
Article Synopsis
- Genetic variability plays a crucial role in differences in skeletal muscle mass, but the specific genes responsible are not well understood; this study focuses on Rps6ka6 and Pou3f4 genes located on chromosome X in mice.
- The study involved analyzing muscle samples from male CFW mice with different alleles linked to muscle mass, revealing that the "increasing" allele led to larger muscle size and more muscle fibers, particularly in the fast-twitch extensor digitorum longus muscle.
- Findings suggest that Rps6ka6 influences muscle fiber count in fast-twitch muscles, whereas the Pou3f4 gene impacts fiber numbers in slow-twitch muscles, indicating distinct genetic roles in muscle development.
We previously found that complement components are upregulated in the myocardium of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), and inhibiting the complement receptor C5aR reduces disease severity in desmin knockout ( ) mice, a model for ARVC. Here, we examined the mechanism underlying complement activation in ARVC, revealing a potential new therapeutic target. First, immunostaining, RT-PCR and western blot were used to detect the expression levels of complement and coagulation factors.
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