Publications by authors named "Konstantinos Katsos"

Various concerns relating to international humanitarian law and human rights were risen by natural catastrophes (tsunamis, floods, fires), the Covid-19 pandemic, the epidemic breakouts of Ebola, as well as the significant migrant wave observed in the Mediterranean region. Forensic Medicine has direct interactions with both domestic and international law, and thus is frequently asked to provide solutions for these issues. The term "Humanitarian Forensic Action" (HFA), which refers to the application of forensic science to serve humanitarian endeavors, was created.

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Background: The analysis of circumstantial elements in post-mortem examinations is crucial for identifying perpetrators in unarmed close-range homicides. This study explores the forensic analysis of head trauma fatalities related to combat sports, blunt force trauma homicides, and traditional martial arts (TMA), aiming to bridge the gap between historical martial arts documentation and modern forensic pathology.

Materials And Methods: Following PRISMA guidelines, we conducted a systematic literature review and interdisciplinary analysis combining traditional forensic methods with the study of TMA manuscripts and consultations with martial arts experts.

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The aim of this study is to review the available knowledge concerning the use of artificial Intelligence (AI) in general in different areas of Forensic Sciences from human identification to postmortem interval estimation and the estimation of different causes of death. This paper aims to emphasize the different uses of AI, especially in Forensic Medicine, and elucidate its technical part. This will be achieved through an explanation of different technologies that have been so far employed and through new ideas that may contribute as a first step to the adoption of new practices and to the development of new technologies.

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Purpose: Stereotactic radiosurgery (SRS) is frequently used in the management of brain metastasis patients. However, there is an urgent need to evaluate post-treatment outcomes and quality of life metrics for patients undergoing SRS for brain metastases.

Methods: The NeuroPoint Alliance (NPA) SRS Quality Registry conducted prospective enrollment of patients undergoing SRS from 2017 to 2024.

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Article Synopsis
  • The study aimed to investigate the incidence of interbody subsidence in patients who underwent transforaminal lumbar interbody fusion (TLIF), along with identifying risk factors and evaluating the consequences of subsidence on complications and fusion rates.
  • A retrospective analysis was conducted on adult patients who had one- or two-level TLIF from 2017-2019, excluding those with certain conditions or incomplete follow-ups, and used CT scans to measure subsidence after surgery.
  • Results indicated that 28% of fusion levels encountered moderate subsidence, while 35% faced severe subsidence, with factors such as cage surface area and material type linked to higher subsidence rates.
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  • The study investigates the effectiveness of synthetic interbody spacers compared to structural bone grafts in lumbar arthrodesis for spine diseases, highlighting gaps in current clinical evidence.
  • It includes a systematic review of 20 studies with over 1500 patients, showing that using interbody cages led to a greater increase in disc height and a more significant reduction in back pain.
  • The findings indicate that interbody cages enhance fusion rates and suggest their importance in clinical practice for treating degenerative spine conditions.
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  • The study investigates the effects of bone morphogenetic protein (BMP) on clinical and radiological outcomes in cervical arthrodesis, specifically comparing cases with and without BMP use in both anterior and posterior fusions.
  • A total of 20 studies with nearly 5,800 patients showed that BMP use in anterior cervical discectomy and fusion (ACDF) was linked to higher fusion rates and lower reoperation rates, but also a higher risk of dysphagia (difficulty swallowing).
  • In contrast, for posterior cervical fusion (PCF), BMP did not significantly affect fusion or reoperation rates, but was associated with higher blood loss during surgery.
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Study Design: Retrospective cohort analysis.

Objective: To determine whether the C2 exposure technique was a predictor of change in cervical alignment and patient-reported outcomes measures (PROMs) after posterior cervical decompression and fusion (PCDF) for degenerative indications.

Background: In PCDF handling of the C2 posterior paraspinal musculature during the operative approach varies by surgeon technique.

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Purpose: To determine if C2 pedicle versus pars screw type predicts change in fusion status, C2 screw loosening, cervical alignment, and patient-reported outcomes measures (PROMs) after C2-T2 posterior cervical decompression and fusion (PDCF).

Methods: All adult patients who underwent C2-T2 PCDF for myelopathy or myeloradiculopathy between 2013-2020 were retrospectively identified. Patients were dichotomized by C2 screw type into bilateral C2 pedicle and bilateral C2 pars screw groups.

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Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I trial (ClinicalTrials.gov: NCT03308565) included 10 patients with American Spinal Injury Association Impairment Scale (AIS) grade A or B at the time of injury.

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Article Synopsis
  • The study investigates the use of machine learning algorithms to predict postoperative range of motion (ROM) and determine ideal implant sizes for cervical disk arthroplasty (CDA) to enhance patient outcomes.
  • Data was collected from 47 patients who had CDA, with factors such as demographics, disk heights, and outcomes analyzed using various machine learning models.
  • The results indicated that the highest-performing model (k-nearest neighbors) yielded an average error of 7.6° in predicting ROM, with optimal implant size identified as 110% of the normal adjacent disk height, highlighting graft size as the most critical factor influencing ROM.
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Background And Objectives: Enhanced recovery after surgery (ERAS) protocols aim to optimize patient outcomes by reducing the surgical stress response, expediting recovery, and reducing care costs. We aimed to evaluate the impact of implementing ERAS protocols on the perioperative surgical outcomes and financial implications associated with spine surgeries.

Methods: A systematic review and meta-analysis of peer-reviewed studies directly comparing outcome differences between spine surgeries performed with and without utilization of ERAS pathways was conducted along Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

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Objective: Along with the increasing interest in real-world evidence in neuro-oncology, the deficiencies of prior population-based and quality registries became evident. The neuro-oncological quality registries of the NeuroPoint Alliance (NPA) focus on neuro-oncological surgery and stereotactic radiosurgery (SRS) and aim to fill the gaps of neuro-oncological practice in quality surveillance and real-world research.

Methods: Herein, we discuss the historical background, design process, and features of the NPA SRS and Tumor QOD registries.

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Both esophageal atresia (EA) and tracheoesophageal fistula (TEF) represent a rather uncommon congenital abnormality that is the result of abnormal tracheoesophageal organogenesis. Although EA, with or without TEF, is relatively uncommon, it represents the most common upper gastrointestinal birth defect. Esophageal atresia and tracheoesophageal fistula are anatomically classified into five types according to the Gross classification (types A, B, C, D, E/H).

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Objective: The literature on non-small cell lung cancer (NSCLC) brain metastases (BMs) managed using stereotactic radiosurgery (SRS) relies mainly on single-institution studies or randomized controlled trials (RCTs). There is a literature gap on clinical and radiological outcomes of SRS for NSCLC metastases in real-world practice. The objective of this study was to benchmark mortality and progression outcomes in patients undergoing SRS for NSCLC BMs and identify risk factors for these outcomes using a national quality registry.

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Many scientists expressed their concerns regarding the impact of COVID-19-related quarantine measures on interpersonal violence, mainly concerning children and intimate partners, as well as other negative psychological effects. During early 2020, free circulation in Greece was prohibited for 42 days, up until May 4th. The aim of our study was to investigate characteristics of bodily harm allegation cases referred to the Department of Forensic Medicine and Toxicology of the Medical School of the National and Kapodistrian University of Athens, Greece, during the first month succeeding free circulation re-establishment in the broader Attica region.

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Spinal cord tumors constitute a diverse group of rare neoplasms associated with significant mortality and morbidity that pose unique clinical and surgical challenges. Diagnostic accuracy and outcome prediction are critical for informed decision making and can promote personalized medicine and facilitate optimal patient management. Machine learning has the ability to analyze and combine vast amounts of data, allowing the identification of patterns and the establishment of clinical associations, which can ultimately enhance patient care.

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Introduction: The close association of dogs with humans may explain the fact that dog bites are possibly the most common animal bites recorded. The relevant data concerning Greece is scarce. We aimed to study this phenomenon by describing its characteristics.

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Cardiac tumors range from benign to high grade malignancies. The incidence of cardiac involvement either by primary, or secondary tumors during autopsy is reported to be extremely low. Extranodal NK/T-cell lymphoma (ENKTL), nasal type is an unusual type of lymphoma.

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Background: Surgical resection of symptomatic pineal cysts without hydrocephalus remains controversial because patients can present with variable symptoms. Hesitancies in surgical decision-making include determining surgical candidacy and whether results would be durable.

Methods: We performed a retrospective analysis on patients who underwent resection of their pineal cysts in our practice.

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Background: Biological rhythms, acting as an endogenous clock, prepare and assist the organism to function optimally during predictable seasonal and daily cycles. Many elements of the cardiovascular system exhibit specific rhythmical patterns. Besides genetic mechanisms, external stimuli may alter biological rhythms.

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