Publications by authors named "Konstantinos Fasseas"
Article Synopsis
- Breast cancer is a major health issue for women and sometimes treatments work less effectively due to resistance.
- Researchers created special cell lines that are resistant to common treatments like fulvestrant and tamoxifen to study why this happens.
- These resistant cells can still grow even without estrogen and show increased survival abilities, which makes finding better treatments even more important.
Background: Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). The aim of the present study was to investigate the effect of DAPT, a γ-secretase inhibitor, in non-small cell lung cancer (NSCLC) cells, as well as the impact of epidermal growth factor (EGF) that is over-expressed by NSCLC cells, on Notch signaling.
View Article and Find Full Text PDFBackground: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons.
Methods: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables.