Risk, time, and psychological distance: Does construal level theory capture the impact of delay on risk preference?

Do people change their preferences when they are offered the same risky lotteries at different times (now vs. the future)? Construal level theory (CLT) suggests that people do because our mental representation of events is moderated by how near or distant such events are in time. According to CLT, in the domain of risk preferences, psychological distance causes payoffs and probabilities to be differentially weighted or attended between present and future timepoints: Temporal distance increases the influence of payoffs and decreases the influence of probabilities.

Tau processing and tau-mediated inflammation differ in human and astrocytes.

Alzheimer's disease (AD) and progressive supra-nuclear palsy (PSP) are both proteinopathies, characterized by the accumulation of tau aggregates. is the greatest genetic risk factor for developing AD, while is a significant risk factor for developing PSP. In the brain, astrocytes are the predominant producer of ApoE, but they are also important for inflammation and overall brain homeostasis.

Violations of transitive preference: A comparison of compensatory and noncompensatory accounts.

Violations of transitive preference can be accounted for by both the noncompensatory lexicographic semiorder heuristic and the compensatory additive difference model. However, the two have not been directly compared. Here, we fully develop a simplified additive difference (SAD) model, which includes a graphical analysis of precisely which parameter values are consistent with adherence to, or violation of, transitive preference, as specified by weak stochastic transitivity (WST) and triangle inequalities (TI).

Categorizing digital data collection and intervention tools in health and wellbeing living lab settings: A modified Delphi study.

Background: Health and Wellbeing Living Labs are a valuable research infrastructure for exploring innovative solutions to tackle complex healthcare challenges and promote overall wellbeing. A knowledge gap exists in categorizing and understanding the types of ICT tools and technical devices employed by Living Labs.

Aim: Define a comprehensive taxonomy that effectively categorizes and organizes the digital data collection and intervention tools employed in Health and Wellbeing Living Lab research studies.

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion.

Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer's disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recently identified the Uppsala APP mutation (APPUpp), which causes Aβ pathology by a triple mechanism: increased β-secretase and altered α-secretase APP cleavage, leading to increased formation of a unique Aβ conformer that rapidly aggregates and deposits in the brain.

Comparative assessment of synthetic time series generation approaches in healthcare: leveraging patient metadata for accurate data synthesis.

Background: Synthetic data is an emerging approach for addressing legal and regulatory concerns in biomedical research that deals with personal and clinical data, whether as a single tool or through its combination with other privacy enhancing technologies. Generating uncompromised synthetic data could significantly benefit external researchers performing secondary analyses by providing unlimited access to information while fulfilling pertinent regulations. However, the original data to be synthesized (e.

Fenneman et al.'s (2022) review of formal impulsivity models: Implications for theory and measures of impulsivity.

In Fenneman et al.'s (2022) review of theories and integrated impulsivity model, the authors distinguish between information impulsivity (i.e.

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology.

Tau deposits in astrocytes are frequently found in Alzheimer's disease (AD) and other tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be of neuronal origin. However, the mechanisms behind their appearance and their relevance for disease progression remain unknown.

Evaluation of the intensity of cigarette odors based on the perception of consumers.

Introduction: We evaluated the tobacco odor intensity of cigarettes based on a large consumer panel and explored the differences of odor intensity perception based on sex, age and smoking habits.

Methods: The perceived intensity of tobacco odor of cigarettes was evaluated using a consumer group method. A consumer panel of 240 volunteers (80 smokers, 80 ex-smokers and 80 non-smokers) was asked to smell eleven unlit cigarettes and then report their tobacco odor intensity in a specific questionnaire.

Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes.

Growing evidence indicates that astrocytes are tightly connected to Alzheimer's disease (AD) pathogenesis. However, the way in which astrocytes participate in AD initiation and progression remains to be clarified. Our previous data show that astrocytes engulf large amounts of aggregated amyloid-beta (Aβ) but are unable to successfully degrade the material.

A systematic investigation into the reliability of inter-temporal choice model parameters.

Decades of work have been dedicated to developing and testing models that characterize how people make inter-temporal choices. Although parameter estimates from these models are often interpreted as indices of latent components of the choice process, little work has been done to examine their reliability. This is problematic because estimation error can bias conclusions that are drawn from these parameter estimates.

Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function.

Background: Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rather than degrade the ingested material, which leads to severe cellular stress. However, the involvement of pathological astrocytes in AD-related synaptic dysfunction remains to be elucidated.

Digital Biomarkers for Well-being Through Exergame Interactions: Exploratory Study.

Background: Ecologically valid evaluations of patient states or well-being by means of new technologies is a key issue in contemporary research in health and well-being of the aging population. The in-game metrics generated from the interaction of users with serious games (SG) can potentially be used to predict or characterize a user's state of health and well-being. There is currently an increasing body of research that investigates the use of measures of interaction with games as digital biomarkers for health and well-being.

CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease M146L mutation.

Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer's disease (AD) brain. The M146L mutation in the PS1 gene () leads to an autosomal dominant form of early-onset AD by promoting a relative increase in the generation of the more aggregation-prone Aβ42. This change is evident not only in the brain but also in peripheral cells of mutation carriers.

Rehabilitation Supported by Technology: Protocol for an International Cocreation and User Experience Study.

Background: Living labs in the health and well-being domain have become increasingly common over the past decade but vary in available infrastructure, implemented study designs, and outcome measures. The Horizon 2020 Project Virtual Health and Wellbeing Living Lab Infrastructure aims to harmonize living lab procedures and open living lab infrastructures to facilitate and promote research activities in the health and well-being domain in Europe and beyond. This protocol will describe the design of a joint research activity, focusing on the use of innovative technology for both rehabilitation interventions and data collection in a rehabilitation context.

Patterns of choice adaptation in dynamic risky environments.

An important aspect of making good decisions is the ability to adapt to changes in the values of available choice options, and research suggests that we are poor at changing behavior and adapting our choices successfully. The current paper contributes to clarifying the role of memory on learning and successful adaptation to changing decision environments. We test two aspects of changing decision environments: the direction of change and the type of feedback.

Correction: Beristain Iraola et al. User Centered Virtual Coaching for Older Adults at Home Using SMART Goal Plans and I-Change Model. 2021, , 6868.

The author would like to change the authorship in the previous publication [...

Digital Biomarkers for Supporting Transitional Care Decisions: Protocol for a Transnational Feasibility Study.

Background: Virtual Health and Wellbeing Living Lab Infrastructure is a Horizon 2020 project that aims to harmonize Living Lab procedures and facilitate access to European health and well-being research infrastructures. In this context, this study presents a joint research activity that will be conducted within Virtual Health and Wellbeing Living Lab Infrastructure in the transitional care domain to test and validate the harmonized Living Lab procedures and infrastructures. The collection of data from various sources (information and communications technology and clinical and patient-reported outcome measures) demonstrated the capacity to assess risk and support decisions during care transitions, but there is no harmonized way of combining this information.

Cocreating a Harmonized Living Lab for Big Data-Driven Hybrid Persona Development: Protocol for Cocreating, Testing, and Seeking Consensus.

Background: Living Labs are user-centered, open innovation ecosystems based on a systematic user cocreation approach, which integrates research and innovation processes in real-life communities and settings. The Horizon 2020 Project VITALISE (Virtual Health and Wellbeing Living Lab Infrastructure) unites 19 partners across 11 countries. The project aims to harmonize Living Lab procedures and enable effective and convenient transnational and virtual access to key European health and well-being research infrastructures, which are governed by Living Labs.

COLAEVA: Visual Analytics and Data Mining Web-Based Tool for Virtual Coaching of Older Adult Populations.

The global population is aging in an unprecedented manner and the challenges for improving the lives of older adults are currently both a strong priority in the political and healthcare arena. In this sense, preventive measures and telemedicine have the potential to play an important role in improving the number of healthy years older adults may experience and virtual coaching is a promising research area to support this process. This paper presents COLAEVA, an interactive web application for older adult population clustering and evolution analysis.

Physical Training In-Game Metrics for Cognitive Assessment: Evidence from Extended Trials with the Fitforall Exergaming Platform.

Conventional clinical cognitive assessment has its limitations, as evidenced by the environmental shortcomings of various neuropsychological tests conducted away from an older person's everyday environment. Recent research activities have focused on transferring screening tests to computerized forms, as well as on developing short screening tests for screening large populations for cognitive impairment. The purpose of this study was to present an exergaming platform, which was widely trialed (116 participants) to collect in-game metrics (built-in game performance measures).