Publications by authors named "Konstantina Tzitzikou"
Transl Psychiatry
June 2024
Article Synopsis
- * The study introduced a machine learning (AutoML) approach to analyze DNA methylation data, leading to the identification of SCZ-specific biomarkers such as IGF2BP1, CENPI, and PSME4 from blood samples of SCZ patients compared to healthy controls.
- * An optimized five-feature biosignature was developed that included gene methylation levels and demographic factors, showing promise for being used in clinical diagnostics for SCZ, with a notable performance accuracy.
Article Synopsis
- Circulating cell-free DNA (ccfDNA) of mitochondrial origin (ccf-mtDNA) is a small part of the total ccfDNA in bodily fluids, with abnormal levels linked to various diseases.
- A new standardized dual-qPCR assay effectively measures nuclear and mitochondrial ccfDNA, revealing that high ccf-mtDNA levels are significant in Breast Cancer and Type 2 Diabetes, but not in Osteoarthritis.
- Machine learning was applied to create biosignatures for diagnosing and predicting outcomes in these diseases, highlighting their potential in improving clinical management.
