Cutaneous T-cell lymphoma: aetiopathogenesis and current diagnostic and therapeutic developments.

Cutaneous T-cell lymphoma is a heterogeneous group of non-Hodgkin's lymphoma, characterized by an infiltration of malignant T cells in the skin. The most common subgroups include mycosis fungoides followed by the aggressive leukaemic variant, Sézary syndrome. The pathophysiology of this neoplasm is poorly understood.

plays a role in hypoxia-induced gustatory plasticity of .

Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of low oxygen levels, inducing expression of genes involved in mediating the response to hypoxia to maintain cellular oxygen homeostasis. is a soil nematode that has evolved specialized chemosensory neurons that detect changes in oxygen levels and guide its behaviour and responses to food. The role of the gene in modifying chemosensory behaviour in response to chemical hypoxia however remains unclear.