Clinical evaluation of PRMT1 gene expression in breast cancer.

Methylation of arginine residues has been implicated in many cellular activities like mRNA splicing, transcription regulation, signal transduction and protein-protein interactions. Protein arginine methyltransferases are the enzymes responsible for this modification in living cells. The most commonly used methyltransferase in man is protein arginine methyltransferase 1 (PRMT1).

Colon cancer and protein arginine methyltransferase 1 gene expression.

Background: In this study, the possible relation of the expression pattern of arginine methyltransferase 1 and colon cancer progression is investigated.

Materials And Methods: Colon cancer samples as well as normal colon samples were used to define the arginine methyltransferase 1 expression by RT-PCR. The results were associated with clinical and histological parameters of the tissues.

Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer.

Human tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases.

SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression.

SR (serine-arginine) proteins are essential pre-mRNA splicing factors. Several SR proteins have been characterized in humans, among them SR-A1. It has been demonstrated by members of our group that the SR-A1 gene is constitutively expressed in most of the human tissues, while its transcription is increased in breast carcinoma cell lines.

Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer.

Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients.