Genetics of bone mineral density: evidence for a major pleiotropic effect from an intercontinental study.

Unlabelled: BMD is a primary predictor of osteoporotic fracture, and its genetic determination is still unclear. This study showed that the correlation between BMD at different skeletal sites is caused by an underlying genetic structure of common genetic effects. In addition to possible shared (pleiotropic) genetic and environmental effects, each of the BMD variables may also be determined by site-specific genetic factors.

Genetic determination of bone mineral density: evidence for a major gene.

This study was designed to test the hypothesis of a major gene influence on the variation in bone mineral density (BMD). BMD and bone mineral content at the lumbar spine and femoral neck were measured in 330 men and 413 women, aged 18-90 yr, from 107 nuclear and complex families (including 5 large pedigrees with 194 individuals who were identified through an index case with moderately high BMD at the femoral neck (z-score, >or=1.28)).

Comparative analysis of age prediction by markers of bone change in the hand assessed by roentgenography.

The major aim of this study was to develop an accurate method of age prediction for a wide range of ages based on the roentgenographic assessment of the hand bones. Such a method may be of particular interest in paleoanthropology and forensic medicine. The present paper provides the results of an analysis of individuals belonging to two ethnically different population samples: 1) Chuvasha (the Russian Federation), 293 males and 254 females, aged 18-91 and 18-86 years, respectively; and 2) Turkmenians (the Republic of Turkmenia), 257 males and 386 females, aged 18-82 and 17-83 years, respectively.