Theory of functional systems in the scientific school of P.K. Anokhin.

In this paper we present brief biographical data of the outstanding Russian physiologist P.K. Anokhin and the stages of formation of the theory of functional systems, proposed by him.

Effect of stress induced by electrical stimulation of the hypothalamus on the electrical stability of the heart in rabbits.

The influence of stress on cardiac electrical stability (CES) and chaotic dynamics of the electrical activity of the heart was studied in acute and chronic experiments in rabbits. Stress was caused by 2-3 h daily immobilization of the animals with electrical stimulation of emotiogenic centers of the hypothalamus through implanted electrodes. CES was estimated by the thresholds for ventricular arrhythmia: paroxysmal ventricular tachycardia, repeated ventricular extrasystoles and ventricular fibrillation (VF).

Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors.

The influence of microiontophoretic application of delta-sleep inducing peptide (DSIP) on a neuronal activity of sensorimotor brain cortex, dorsal hippocampus, ventral anterior thalamic nucleus and lateral hypothalamus was studied under the effects of glutamate and MK-801, a N-methyl-d-aspartate non-competitive antagonist, on male Wistar rats. DSIP microiontophoresis predominantly activated neurons of various brain regions, in particular, dorsal hippocampus and ventral anterior thalamic nucleus. A preliminary DSIP microiontophoresis prevented the augmentation of a neuronal activity in the studied structures under glutamate microiontophoresis.

[Emotional stress as an illness-related factor].

Introduction: Emotions represent reactions of living organisms to changes of one's inner sphere, as well as to different factors from our surroundings. Emotions manifest in many ways. Failing to fulfill one's needs on chronic or acute basis leads to conflict situations.

Impulse activity of individual sensorimotor cortex neurons in rabbits after microiontophoretic administration of antibodies against acid fibroblast growth factor.

We studied the sensitivity of sensorimotor cortex neurons in rabbits to microiontophoretic administration of antibodies against acid fibroblast growth factor (anti-aFGF). Spontaneous activity and reaction of neurons to electrical stimulation of 'feeding centers' in the lateral hypothalamic area (LHA) were recorded. We analyzed impulse activity of 52 neurons in the sensorimotor cortex.