Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism.

Synthetic cannabinoid receptor agonists (SCRAs) have become a wide group of new psychoactive substances since the 2010s. For the last few years, the X-ray structures of the complexes of cannabinoid receptor I (CB) with SCRAs as well as the complexes of CB with its antagonist have been published. Based on those data, SCRA-CB interactions are analyzed in detail, using molecular modeling and molecular dynamics simulations.