Publications by authors named "Konstantin Seleznev"
Article Synopsis
- Mitochondria produce reactive oxygen species (ROS), which are crucial in triggering apoptosis, with cardiolipin in the mitochondrial membrane as a primary target for ROS damage.
- The group VIA Ca2+-independent phospholipase A2 (iPLA2) appears to protect mitochondrial function by preventing apoptosis induced by staurosporine (STS), as iPLA2-expressing cells showed resistance to STS-induced damage.
- STS decreases the transcription of iPLA2, potentially impairing mitochondrial membrane repair and contributing to mitochondrial failure and cell death.
The G1 phase of the cell cycle is characterized by a high rate of membrane phospholipid turnover. Cells regulate this turnover by coordinating the opposing actions of CTP:phosphocholine cytidylyltransferase and the group VI Ca2+-independent phospholipase A2 (iPLA2). However, little is known about how such turnover affects cell-cycle progression.
View Article and Find Full Text PDF