Publications by authors named "Konstantin Sadov"
Article Synopsis
- * The study tested the effectiveness of a new drug, DOKSI AVZ 500, on Yorkshire piglets with respiratory issues, comparing it to a standard drug, TETRAMAX 500, over a treatment period of 3 to 5 days.
- * Results showed that both drugs were well tolerated, leading to quick recovery in about 4 days, normalization of health indicators, and significant weight gain, making DOKSI AVZ 500 a strong candidate for use in veterinary practice alongside TETRAMAX 500.
Background: A supramolecular complex of praziquantel (PZQ) with disodium salt of glycyrrhizic acid (NaGA) was obtained by mechanochemical technology to increase solubility, absorption rate and hence bioavailability of the drug and reduction its therapeutic doses. The aim of our study was evaluation of anthelmintic efficacy of supramolecular complex of PZQ.
Methods: Different samples of PZQ with NaGA were obtained by mechanochemical processing and examined for some physico-chemical properties.
Objective: The purpose of our research was to evaluate the effect of mechanochemical technology on the efficacy of supramolecular complex of fenbendazole (SMCF) with polyvinylpyrrolidone (PVP) polymer against some helminthosis of animals.
Materials And Methods: The SMCF samples with PVP were synthesized using a solid-state mechanochemical technology in activators of impact-abrading type and their physicochemical properties were analyzed. The efficacy of SMCF was studied on the laboratory model of and infection of mice and helminthosis of sheep.
Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery was studied in hymenolepiosis of mice and monieziosis of sheep. The efficacy of new substances of niclosamide with polyvinylpyrrolidone polymer in different ratios (1:10; 1:5; 1:2) was determined by the results of helminthological necropsy of the small intestine of sheep and mice.
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