Publications by authors named "Konstantin S Leskov"
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Synopsis of recent research by authors named "Konstantin S Leskov"
- Konstantin S Leskov's research predominantly focuses on the roles of different proteins in T cell responses and apoptosis, with significant emphasis on the cyclin-dependent kinase (CdK2) and clusterin (CLU) in various cellular contexts, particularly concerning autoimmune diseases and cancer.
- His findings indicate that Roscovitine can suppress CD4+ T cell activity and T cell-mediated experimental uveitis, while synthetic triterpenoids like CDDO and their derivatives reveal high anti-tumor potency in pediatric solid tumor cell lines.
- Leskov's work also explores the dual roles of clusterin, as pro-survival and pro-death factors in response to stress, alongside the mechanisms regulating nuclear clusterin's involvement in apoptosis and its potential ties to ionizing radiation-induced cellular responses.
