Publications by authors named "Konstantin C Zouboulis"
Pharmaceutics
February 2023
Article Synopsis
- Recent advancements in hidradenitis suppurativa (HS) research have faced challenges due to rapid therapeutic development and lack of outcome measures, leading to the halt of some studies.
- The HS 3D-SeboSkin model, which combines human skin and sebocytes, has been utilized to study the effects of adalimumab, an approved biologic that targets inflammatory cells and promotes healing in HS lesions.
- Adalimumab shows varying effects on cellular proteins in patients, reducing several inflammatory markers while failing to alter abnormal cell differentiation, highlighting the need for personalized approaches in treatment development.
Pharmaceutics
December 2021
Article Synopsis
- Chronic inflammation and issues with hair follicle cell differentiation are key factors in the development of hidradenitis suppurativa (HS), with obesity and metabolic syndrome also being significant risk factors.
- A systematic review examined the molecular mechanisms behind HS, identifying biomarkers and potential repurposing of existing drugs, including adalimumab, which is already approved for this condition.
- The study confirmed the interconnected nature of HS with other comorbidities like inflammatory bowel disease and arthritis, highlighting the importance of molecular research for better understanding and treatment of HS.
