Publications by authors named "Konstantin A Pavlov"
The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy, critically depends on the activity of the host immune cells. However, various local and systemic mechanisms of immunosuppression operate in cancer patients. Tumor-associated immunosuppression involves deregulation of many components of immunity, including a decrease in the number of T lymphocytes (lymphopenia), an increase in the levels or ratios of circulating and tumor-infiltrating immunosuppressive subsets [e.
View Article and Find Full Text PDFIntroduction: Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Biomarkers of impaired neurogenesis in depression can act as a useful objective and diagnostic and prognostic tool to determine the severity of depression.
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- The study aimed to synthesize comprehensive data on the prevalence of NMDAR antibodies in psychotic patients to assess their clinical significance and address inconsistencies in findings.* -
- A total of 47 studies and 4 systematic reviews were reviewed, revealing that methods of detecting NMDAR antibodies greatly influenced results, and better detection techniques are needed for accurate prevalence assessment.* -
- The findings indicate that NMDAR antibodies are present in some psychotic patients and may influence symptoms; thus, immunotherapy could be a potential treatment for those unresponsive to standard therapies, but further research is needed.*
Objective: To investigate the role of matrix metalloproteinases (MMP-2, MMP-9) and their inducer (CD147) in premature rupture of membranes (PROM) at term labor.
Methods: In a cross-sectional study, 24 women aged 19-39, with 37-40-week pregnancy, and no clinical and histological signs of chorioamnionitis, were divided into two groups with and without PROM. The histological and immunohistochemical study of the fetal membranes was performed with polyclonal rabbit antibodies to MMP-2/MMP-9 and monoclonal rabbit antibodies to CD147.
Human aggression/impulsivity-related traits have a complex background that is greatly influenced by genetic and non-genetic factors. The relationship between aggression and anxiety is regulated by highly conserved brain regions including amygdala, which controls neural circuits triggering defensive, aggressive, or avoidant behavioral models. The dysfunction of neural circuits responsible for emotional control was shown to represent an etiological factor of violent behavior.
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