Publications by authors named "Konstantin A Babalyan"
Article Synopsis
- Muscle fiber composition influences athletic performance, with endurance athletes having more slow-twitch fibers, which are linked to genetics, specifically the rs236448 SNP near the CDKN1A gene.
- Research indicates that the rs236448 A allele is associated with a higher proportion of slow-twitch fibers in various ethnic cohorts, particularly among elite endurance athletes, while the C allele favors fast-twitch fibers.
- Additionally, CDKN1A expression is linked to muscle fiber types, with higher levels in strength athletes, suggesting the SNP could play a role in determining an individual's predisposition to either endurance or power sports.
Extracellular circulating microRNAs (miRNAs) are currently a focus of interest as non-invasive biomarkers of cardiovascular pathologies, including coronary artery disease (CAD) and acute coronary syndromes (ACS): myocardial infarction with and without ST-segment elevation (STEMI and NSTEMI) and unstable angina (UA). However, the current data for some miRNAs are controversial and inconsistent, probably due to pre-analytical and methodological variances in different studies. In this work, we fulfilled the basic pre-analytical requirements provided for circulating miRNA studies for application to stable CAD and ACS research.
View Article and Find Full Text PDFPurpose: Preclinical evaluation of and transcript simultaneous detection in urine to diagnose clinical significant prostate cancer (prostate cancer with Gleason score ≥7) in a Russian cohort.
Patients And Methods: We analyzed urine samples of patients with a total serum PSA ≥2 ng/mL: 31 men with prostate cancer scheduled for radical prostatectomy, 128 men scheduled for first diagnostic biopsy (prebiopsy cohort). , , and transcripts were detected by multiplex reverse transcription quantitative polymerase chain reaction, and the results were used for scores for calculation and statistical analysis.
The potential of extracellular circulating microRNAs (miRNAs) as non-invasive biomarkers of atrial fibrillation (AF) has been confirmed by a number of recent studies. However, the current data for some miRNAs are controversial and inconsistent, probably due to pre-analytical and methodological differences. In this work, we attempted to fulfill the basic pre-analytical requirements provided for circulating miRNA studies for application to paroxysmal atrial fibrillation (PAF) research.
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