Publications by authors named "Konsta R Duesing"
Article Synopsis
- Carcinogenesis causes changes in DNA methylation, which can help find cancer early and guide treatment decisions.
- These changes often affect specific areas of DNA linked to genes, making them useful for creating tests that are simple and effective.
- By analyzing DNA from blood, urine, or tumor tissue, doctors can monitor cancer responses to treatment and even check for future recurrence.
Background: The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests.
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