Metabolic characteristics of women diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria - our own experience.

Objectives: Analysis of metabolic features of women diagnosed with the PCOS among female patients of Department of Endocrinology and Metabolic Diseases, the Polish Mother's Memorial Hospital - Research Institute (DEMD, PMMH-RI). The secondary aim was assessment if diagnosis of PCOS (according to the Rotterdam criteria) may imply any standard treatment.

Material And Methods: The study was retrospective analysis of patients hospitalized in DEMD.

Insulin resistance - "the good or the bad and ugly".

Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects of insulin action, i.e.

Gestational diabetes - is diet and insulin the only solution?

Gestational diabetes (GDM) is a relatively common complication of pregnancy. Maternal hyperglycemia causes many serious side effects for mothers, fetuses and newborns. In 90% of women diagnosed with GDM, a dietary treatment results in satisfactory levels of blood glucose.

In quest for method of insulin resistance assessment in everyday clinical practice-Insulin resistance indices.

Unlabelled: Insulin resistance (IR) a state of decreased sensitivity of target tissues to insulin is suspected usually in obese so can be overlooked in normal weight subjects thus it is important to find optimal method of IR assessment in clinical practice.

Methods: HOMA, HOMA2, QUICKI, Matsuda index were calculated using data obtained from medical history of 130 female subjects - patients of the Department of Endocrinology and Metabolic Diseases, in whom oral glucose tolerance test (OGTT) with parallel insulin concentrations assessment was performed.

Results: IR correlated positively with body mass index (BMI) in the entire study group, regardless which of four analyzed IR indices was used.

Hyperprolactinemia diagnostics--dilemmas over optimal selection of prolactinemia time points.

Introduction: Laboratory discrimination of pathologic hyperprolactinemia is an important step in the diagnosis of pathology influencing overall health and fertility. A major issue is the choice of time and circumstances for obtaining a blood sample for prolactin assay that would be representative for mean daily plasma concentration of a subject.

Objectives: The aim of the study was a comparison of reliability of single prolactin assessment on various time-points in a day with circadian prolactinemia profile in order to find the easiest, the least expensive, and the most reliable method of hyperprolactinemia diagnosis.

Prolactin secretion in polycystic ovary syndrome (PCOS).

Objectives: Hyperprolactinemia and polycystic ovary syndrome (PCOS) are on the list of the most frequent causes of female infertility. Both pathologies are characterized in common by several clinical features. At the same time, there are essential discrepancies in medical literature on mutual relations between PCOS and hyperprolactinemia.

[Pheochromocytoma - chromaffin cell tumor].

Pheochromocytoma is a rare tumor derived from chromaffin cells, which produces catecholamins. The presence of this tumor is considered a cause of secondary hypertension, arrhythmias, sweating and also, but very rarely, mental disorders. Update diagnostic methods of pheochromocytoma are summarized in this article.

Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices.

Polycystic ovary syndrome (PCOS) is associated with an increased incidence of insulin resistance (IR), obesity, and type 2 diabetes. Resistin, an adipocytokine, may represent a link between obesity, and these metabolic disorders. There is also evidence that inflammation is a hyperresistinemic state in humans, and cytokine induction of resistin may contribute to insulin resistance in endotoxemia, obesity, and other inflammatory states.